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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 1995 Volume 7 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 1995 Volume 7 Issue 4

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Article

THE HIV TAT GENE IS A PROMOTER OF EPIDERMAL SKIN TUMORS

  • Authors:
    • J VOGEL
    • M CEPEDA
    • AH ENK
    • L NGO
    • G JAY

  • View Affiliations / Copyright

    Affiliations: AMER RED CROSS,JEROME H HOLLAND LAB,DEPT VIROL,ROCKVILLE,MD 20855. UNIV MAINZ,DEPT DERMATOL,D-55101 MAINZ,GERMANY.
  • Pages: 727-733
    |
    Published online on: October 1, 1995
       https://doi.org/10.3892/ijo.7.4.727
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Abstract

Human immunodeficiency virus (HIV) infected patients have a very high incidence (>90%) of neoplastic and non-neoplastic skin disorders. The proliferative lesions frequently involve the epidermis and include squamous and basal cell carcinomas, and the papulosquamous diseases of seborrheic dermatitis and psoriasis. Although the role played by HIV in the development of these proliferative skin lesions is not clear, there are several lines of evidence suggesting that HIV may play a causative role. We show that transgenic mice carrying the HIV tat gene under the control of the viral LTR constitutively express the tnt gene in keratinocytes. When a single subthreshold dose of a carcinogen initiator is topically applied to these mice, tumor promoters are no longer required to induce the development of epidermal skin tumors, suggesting that Tat expression in keratinocytes is capable of substituting for phorbol ester tumor promoters in the two-step carcinogenesis skin cancer model. Together, Tat and phorbol ester have additive effects in promoting tumors in transgenic mice first initiated with carcinogens. We conclude that although Tat alone is insufficient to cause epidermal tumors, it functions as a tumor promoter and predisposes these mice to develop tumors following an initiating event.

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Copy and paste a formatted citation
Spandidos Publications style
VOGEL J, CEPEDA M, ENK A, NGO L and JAY G: THE HIV TAT GENE IS A PROMOTER OF EPIDERMAL SKIN TUMORS. Int J Oncol 7: 727-733, 1995.
APA
VOGEL, J., CEPEDA, M., ENK, A., NGO, L., & JAY, G. (1995). THE HIV TAT GENE IS A PROMOTER OF EPIDERMAL SKIN TUMORS. International Journal of Oncology, 7, 727-733. https://doi.org/10.3892/ijo.7.4.727
MLA
VOGEL, J., CEPEDA, M., ENK, A., NGO, L., JAY, G."THE HIV TAT GENE IS A PROMOTER OF EPIDERMAL SKIN TUMORS". International Journal of Oncology 7.4 (1995): 727-733.
Chicago
VOGEL, J., CEPEDA, M., ENK, A., NGO, L., JAY, G."THE HIV TAT GENE IS A PROMOTER OF EPIDERMAL SKIN TUMORS". International Journal of Oncology 7, no. 4 (1995): 727-733. https://doi.org/10.3892/ijo.7.4.727
Copy and paste a formatted citation
x
Spandidos Publications style
VOGEL J, CEPEDA M, ENK A, NGO L and JAY G: THE HIV TAT GENE IS A PROMOTER OF EPIDERMAL SKIN TUMORS. Int J Oncol 7: 727-733, 1995.
APA
VOGEL, J., CEPEDA, M., ENK, A., NGO, L., & JAY, G. (1995). THE HIV TAT GENE IS A PROMOTER OF EPIDERMAL SKIN TUMORS. International Journal of Oncology, 7, 727-733. https://doi.org/10.3892/ijo.7.4.727
MLA
VOGEL, J., CEPEDA, M., ENK, A., NGO, L., JAY, G."THE HIV TAT GENE IS A PROMOTER OF EPIDERMAL SKIN TUMORS". International Journal of Oncology 7.4 (1995): 727-733.
Chicago
VOGEL, J., CEPEDA, M., ENK, A., NGO, L., JAY, G."THE HIV TAT GENE IS A PROMOTER OF EPIDERMAL SKIN TUMORS". International Journal of Oncology 7, no. 4 (1995): 727-733. https://doi.org/10.3892/ijo.7.4.727
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