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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 1995 Volume 7 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 1995 Volume 7 Issue 4

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Article

COMBINATIONS OF TNP-470 OR SR-4233 WITH ANTITUMOR ALKYLATING-AGENTS IN EMT-6 SPHEROIDS AND MONOLAYERS

  • Authors:
    • SA HOLDEN
    • BA TEICHER

  • View Affiliations / Copyright

    Affiliations: DANA FARBER CANC INST,BOSTON,MA 02115. JOINT CTR RADIAT THERAPY,BOSTON,MA 02115.
  • Pages: 777-781
    |
    Published online on: October 1, 1995
       https://doi.org/10.3892/ijo.7.4.777
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Abstract

EMT-6/Parent and EMT-6/CDDP and EMT-6/CTX in vivo alkylating agent resistant cells were grown as spheroids or as monolayers and their response to cis-diamminedichloroplatinum(II) or 4-hydroperoxycyclophosphamide exposure for 1 h alone or in combination with TNP-470 or SR-4233 was determined. When grown as spheroids, each of the three cell lines were less responsive to cis-diamminedichloroplatinum(II) and 4-hydroperoxycyclophosphamide exposure than when the cells were grown and drug-treated in monolayer. The hypoxic cell selective cytotoxic agent SR-4233 was additive in cytotoxicity with the antitumor alkylating agents in both the monolayer and spheroid cultures as determined by isobologram analysis. The antiangiogenic agent TNP-470 was synergistic in cytotoxicity in combination with cis-diammedichloroplatinum in each of the three cell lines when the cells were grown in monolayer and was additive in cytotoxicity with cis-diamminedichloroplatinum(II) when the cells were grown as spheroids. The combination of TNP-470 and 4-hydroperoxycyclophosphamide resulted in additive cytotoxicity toward both monolayer cultures and spheroids. Thus, co-exposure with TNP-470 or SR-4233 increased the cytotoxicity of the antitumor alkylating agents in both the parental and drug resistant cells grown as monolayers or spheroids.

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Copy and paste a formatted citation
Spandidos Publications style
HOLDEN S and TEICHER B: COMBINATIONS OF TNP-470 OR SR-4233 WITH ANTITUMOR ALKYLATING-AGENTS IN EMT-6 SPHEROIDS AND MONOLAYERS. Int J Oncol 7: 777-781, 1995.
APA
HOLDEN, S., & TEICHER, B. (1995). COMBINATIONS OF TNP-470 OR SR-4233 WITH ANTITUMOR ALKYLATING-AGENTS IN EMT-6 SPHEROIDS AND MONOLAYERS. International Journal of Oncology, 7, 777-781. https://doi.org/10.3892/ijo.7.4.777
MLA
HOLDEN, S., TEICHER, B."COMBINATIONS OF TNP-470 OR SR-4233 WITH ANTITUMOR ALKYLATING-AGENTS IN EMT-6 SPHEROIDS AND MONOLAYERS". International Journal of Oncology 7.4 (1995): 777-781.
Chicago
HOLDEN, S., TEICHER, B."COMBINATIONS OF TNP-470 OR SR-4233 WITH ANTITUMOR ALKYLATING-AGENTS IN EMT-6 SPHEROIDS AND MONOLAYERS". International Journal of Oncology 7, no. 4 (1995): 777-781. https://doi.org/10.3892/ijo.7.4.777
Copy and paste a formatted citation
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Spandidos Publications style
HOLDEN S and TEICHER B: COMBINATIONS OF TNP-470 OR SR-4233 WITH ANTITUMOR ALKYLATING-AGENTS IN EMT-6 SPHEROIDS AND MONOLAYERS. Int J Oncol 7: 777-781, 1995.
APA
HOLDEN, S., & TEICHER, B. (1995). COMBINATIONS OF TNP-470 OR SR-4233 WITH ANTITUMOR ALKYLATING-AGENTS IN EMT-6 SPHEROIDS AND MONOLAYERS. International Journal of Oncology, 7, 777-781. https://doi.org/10.3892/ijo.7.4.777
MLA
HOLDEN, S., TEICHER, B."COMBINATIONS OF TNP-470 OR SR-4233 WITH ANTITUMOR ALKYLATING-AGENTS IN EMT-6 SPHEROIDS AND MONOLAYERS". International Journal of Oncology 7.4 (1995): 777-781.
Chicago
HOLDEN, S., TEICHER, B."COMBINATIONS OF TNP-470 OR SR-4233 WITH ANTITUMOR ALKYLATING-AGENTS IN EMT-6 SPHEROIDS AND MONOLAYERS". International Journal of Oncology 7, no. 4 (1995): 777-781. https://doi.org/10.3892/ijo.7.4.777
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