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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 1995 Volume 7 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 1995 Volume 7 Issue 4

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Article

BETACELLULIN, A MEMBER OF THE EPIDERMAL GROWTH-FACTOR FAMILY, IS OVEREXPRESSED IN HUMAN PANCREATIC-CANCER

  • Authors:
    • M YOKOYAMA
    • H FUNATOMI
    • MS KOBRIN
    • M EBERT
    • H FRIESS
    • MW BUCHLER
    • M KORC

  • View Affiliations / Copyright

    Affiliations: UNIV CALIF IRVINE,DEPT MED,DIV ENDOCRINOL DIABET & METAB,IRVINE,CA 92717. UNIV CALIF IRVINE,DEPT BIOL CHEM,IRVINE,CA 92717. UNIV BERN,INSELSPITAL,DEPT VISCERAL & TRANSPLANTAT SURG,CH-3010 BERN,SWITZERLAND.
  • Pages: 825-829
    |
    Published online on: October 1, 1995
       https://doi.org/10.3892/ijo.7.4.825
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Abstract

Human pancreatic ductal adenocarcinomas overexpress the epidermal growth factor (EGF) receptor. Betacellulin is a mitogenic polypeptide that binds and activates this receptor. To determine whether betacellulin has a role in human pancreatic cancer, we studied its expression in cultured human pancreatic cancer cell lines and in normal and cancerous pancreatic tissues. Five of 6 pancreatic cancer cell lines expressed the 3 kb betacellulin mRNA moiety, T3M4, MiaPaCa-2 and COLO-357 cells exhibiting the highest expression levels. EGF, heparin-binding EGF-like growth factor (HB-EGF), and basic fibroblast growth factor (bFGF) increased betacelullin mRNA levels. Only 2 of 15 normal samples and 1 of 10 cancer samples failed to exhibit the betacellulin transcript. Densitometric analysis of the autoradiographs revealed a 7.5-fold increase in betacellulin mRNA levels in the cancer tissues by comparison with the normal tissues. By in situ hybridization, the duct-like cancer cells exhibited many betacellulin mRNA in situ hybridization grains. These findings indicate that human pancreatic cancer cells express betacellulin in culture and in vivo, and suggest that this EGF-like ligand may participate in aberrant autocrine and paracrine activation of the EGF receptor in human pancreatic cancer.

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Copy and paste a formatted citation
Spandidos Publications style
YOKOYAMA M, FUNATOMI H, KOBRIN M, EBERT M, FRIESS H, BUCHLER M and KORC M: BETACELLULIN, A MEMBER OF THE EPIDERMAL GROWTH-FACTOR FAMILY, IS OVEREXPRESSED IN HUMAN PANCREATIC-CANCER. Int J Oncol 7: 825-829, 1995.
APA
YOKOYAMA, M., FUNATOMI, H., KOBRIN, M., EBERT, M., FRIESS, H., BUCHLER, M., & KORC, M. (1995). BETACELLULIN, A MEMBER OF THE EPIDERMAL GROWTH-FACTOR FAMILY, IS OVEREXPRESSED IN HUMAN PANCREATIC-CANCER. International Journal of Oncology, 7, 825-829. https://doi.org/10.3892/ijo.7.4.825
MLA
YOKOYAMA, M., FUNATOMI, H., KOBRIN, M., EBERT, M., FRIESS, H., BUCHLER, M., KORC, M."BETACELLULIN, A MEMBER OF THE EPIDERMAL GROWTH-FACTOR FAMILY, IS OVEREXPRESSED IN HUMAN PANCREATIC-CANCER". International Journal of Oncology 7.4 (1995): 825-829.
Chicago
YOKOYAMA, M., FUNATOMI, H., KOBRIN, M., EBERT, M., FRIESS, H., BUCHLER, M., KORC, M."BETACELLULIN, A MEMBER OF THE EPIDERMAL GROWTH-FACTOR FAMILY, IS OVEREXPRESSED IN HUMAN PANCREATIC-CANCER". International Journal of Oncology 7, no. 4 (1995): 825-829. https://doi.org/10.3892/ijo.7.4.825
Copy and paste a formatted citation
x
Spandidos Publications style
YOKOYAMA M, FUNATOMI H, KOBRIN M, EBERT M, FRIESS H, BUCHLER M and KORC M: BETACELLULIN, A MEMBER OF THE EPIDERMAL GROWTH-FACTOR FAMILY, IS OVEREXPRESSED IN HUMAN PANCREATIC-CANCER. Int J Oncol 7: 825-829, 1995.
APA
YOKOYAMA, M., FUNATOMI, H., KOBRIN, M., EBERT, M., FRIESS, H., BUCHLER, M., & KORC, M. (1995). BETACELLULIN, A MEMBER OF THE EPIDERMAL GROWTH-FACTOR FAMILY, IS OVEREXPRESSED IN HUMAN PANCREATIC-CANCER. International Journal of Oncology, 7, 825-829. https://doi.org/10.3892/ijo.7.4.825
MLA
YOKOYAMA, M., FUNATOMI, H., KOBRIN, M., EBERT, M., FRIESS, H., BUCHLER, M., KORC, M."BETACELLULIN, A MEMBER OF THE EPIDERMAL GROWTH-FACTOR FAMILY, IS OVEREXPRESSED IN HUMAN PANCREATIC-CANCER". International Journal of Oncology 7.4 (1995): 825-829.
Chicago
YOKOYAMA, M., FUNATOMI, H., KOBRIN, M., EBERT, M., FRIESS, H., BUCHLER, M., KORC, M."BETACELLULIN, A MEMBER OF THE EPIDERMAL GROWTH-FACTOR FAMILY, IS OVEREXPRESSED IN HUMAN PANCREATIC-CANCER". International Journal of Oncology 7, no. 4 (1995): 825-829. https://doi.org/10.3892/ijo.7.4.825
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