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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 1995 Volume 7 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 1995 Volume 7 Issue 4

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Article

HEPATOCYTE GROWTH-FACTOR AND ITS RECEPTOR C-MET REGULATE BOTH CELL-GROWTH AND INVASION OF HUMAN PANCREATIC-CANCER

  • Authors:
    • Y HASEGAWA
    • M YAMAMOTO
    • S MAEDA
    • Y SAITOH

  • View Affiliations / Copyright

    Affiliations: KOBE UNIV, SCH MED, DEPT PATHOL 2, CHUO KU, KOBE 650, JAPAN.
  • Pages: 877-881
    |
    Published online on: October 1, 1995
       https://doi.org/10.3892/ijo.7.4.877
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Abstract

Hepatocyte growth factor (HGF) has an important role not only in liver regeneration buy also in the development of cancer metastasis. It has been known that HGF and its receptor/c-MET are overexpressed in human pancreatic cancer in vivo, compared with the normal pancreas. To examine the propensity of pancreatic cancer to metastasize and its association with poor prognosis, we studied the effects of HGF and c-MET on pancreatic cancer cell growth and invasion in vitro. Dose-dependently, HGF promoted both the growth and invasiveness of pancreatic cancer cells that expressed c-MET; as a chemoattractant, the high gradient of HGF determined the direction of the invasiveness of the cells. No stimulant effect, however, was observed in cancer cells that did not express c-MET. These results suggest that HGF and c-MET may play important roles in human pancreatic cancer cell growth and invasion-metastatic potential.

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Copy and paste a formatted citation
Spandidos Publications style
HASEGAWA Y, YAMAMOTO M, MAEDA S and SAITOH Y: HEPATOCYTE GROWTH-FACTOR AND ITS RECEPTOR C-MET REGULATE BOTH CELL-GROWTH AND INVASION OF HUMAN PANCREATIC-CANCER. Int J Oncol 7: 877-881, 1995.
APA
HASEGAWA, Y., YAMAMOTO, M., MAEDA, S., & SAITOH, Y. (1995). HEPATOCYTE GROWTH-FACTOR AND ITS RECEPTOR C-MET REGULATE BOTH CELL-GROWTH AND INVASION OF HUMAN PANCREATIC-CANCER. International Journal of Oncology, 7, 877-881. https://doi.org/10.3892/ijo.7.4.877
MLA
HASEGAWA, Y., YAMAMOTO, M., MAEDA, S., SAITOH, Y."HEPATOCYTE GROWTH-FACTOR AND ITS RECEPTOR C-MET REGULATE BOTH CELL-GROWTH AND INVASION OF HUMAN PANCREATIC-CANCER". International Journal of Oncology 7.4 (1995): 877-881.
Chicago
HASEGAWA, Y., YAMAMOTO, M., MAEDA, S., SAITOH, Y."HEPATOCYTE GROWTH-FACTOR AND ITS RECEPTOR C-MET REGULATE BOTH CELL-GROWTH AND INVASION OF HUMAN PANCREATIC-CANCER". International Journal of Oncology 7, no. 4 (1995): 877-881. https://doi.org/10.3892/ijo.7.4.877
Copy and paste a formatted citation
x
Spandidos Publications style
HASEGAWA Y, YAMAMOTO M, MAEDA S and SAITOH Y: HEPATOCYTE GROWTH-FACTOR AND ITS RECEPTOR C-MET REGULATE BOTH CELL-GROWTH AND INVASION OF HUMAN PANCREATIC-CANCER. Int J Oncol 7: 877-881, 1995.
APA
HASEGAWA, Y., YAMAMOTO, M., MAEDA, S., & SAITOH, Y. (1995). HEPATOCYTE GROWTH-FACTOR AND ITS RECEPTOR C-MET REGULATE BOTH CELL-GROWTH AND INVASION OF HUMAN PANCREATIC-CANCER. International Journal of Oncology, 7, 877-881. https://doi.org/10.3892/ijo.7.4.877
MLA
HASEGAWA, Y., YAMAMOTO, M., MAEDA, S., SAITOH, Y."HEPATOCYTE GROWTH-FACTOR AND ITS RECEPTOR C-MET REGULATE BOTH CELL-GROWTH AND INVASION OF HUMAN PANCREATIC-CANCER". International Journal of Oncology 7.4 (1995): 877-881.
Chicago
HASEGAWA, Y., YAMAMOTO, M., MAEDA, S., SAITOH, Y."HEPATOCYTE GROWTH-FACTOR AND ITS RECEPTOR C-MET REGULATE BOTH CELL-GROWTH AND INVASION OF HUMAN PANCREATIC-CANCER". International Journal of Oncology 7, no. 4 (1995): 877-881. https://doi.org/10.3892/ijo.7.4.877
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