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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 1995 Volume 7 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1995 Volume 7 Issue 5

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Article

SPECIFIC RECOGNITION OF A TRANSCRIPTIONAL ELEMENT WITHIN THE HUMAN H-RAS PROTOONCOGENE BY THE P53 TUMOR-SUPPRESSOR

  • Authors:
    • DA SPANDIDOS
    • V ZOUMPOURLIS
    • G ZACHOS
    • SH TOAS
    • TD HALAZONETIS

  • View Affiliations / Copyright

    Affiliations: UNIV CRETE,SCH MED,IRAKLION,GREECE. UNIV PENN,DEPT MOLEC ONCOL,PHILADELPHIA,PA 19104. UNIV PENN,DEPT PATHOL & LAB MED,PHILADELPHIA,PA 19104.
  • Pages: 1029-1034
    |
    Published online on: November 1, 1995
       https://doi.org/10.3892/ijo.7.5.1029
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Abstract

The nuclear phosphoprotein p53 is frequently inactivated in human cancer. Although it was previously classified as an oncoprotein, p53 has emerged as a tumor suppressor controlling cell cycle progression by regulating gene transcription. A major biochemical property of wild-type p53 is its ability to bind DNA in a sequence-specific manner. The human c-H-ras gene contains within its first intron sequences that partially match the p53 consensus binding site. We determined that these sequences represent a bona fide p53 element, since in vitro translated wild-type p53 recognized them with high affinity. Furthermore, wild-type p53 activated transcription from a reporter plasmid containing the c-H-ras element as an enhancer. These findings suggest that p53 regulates cellular growth by coordinate transcription of genes that suppress and promote cellular proliferation.

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Copy and paste a formatted citation
Spandidos Publications style
SPANDIDOS D, ZOUMPOURLIS V, ZACHOS G, TOAS S and HALAZONETIS T: SPECIFIC RECOGNITION OF A TRANSCRIPTIONAL ELEMENT WITHIN THE HUMAN H-RAS PROTOONCOGENE BY THE P53 TUMOR-SUPPRESSOR. Int J Oncol 7: 1029-1034, 1995.
APA
SPANDIDOS, D., ZOUMPOURLIS, V., ZACHOS, G., TOAS, S., & HALAZONETIS, T. (1995). SPECIFIC RECOGNITION OF A TRANSCRIPTIONAL ELEMENT WITHIN THE HUMAN H-RAS PROTOONCOGENE BY THE P53 TUMOR-SUPPRESSOR. International Journal of Oncology, 7, 1029-1034. https://doi.org/10.3892/ijo.7.5.1029
MLA
SPANDIDOS, D., ZOUMPOURLIS, V., ZACHOS, G., TOAS, S., HALAZONETIS, T."SPECIFIC RECOGNITION OF A TRANSCRIPTIONAL ELEMENT WITHIN THE HUMAN H-RAS PROTOONCOGENE BY THE P53 TUMOR-SUPPRESSOR". International Journal of Oncology 7.5 (1995): 1029-1034.
Chicago
SPANDIDOS, D., ZOUMPOURLIS, V., ZACHOS, G., TOAS, S., HALAZONETIS, T."SPECIFIC RECOGNITION OF A TRANSCRIPTIONAL ELEMENT WITHIN THE HUMAN H-RAS PROTOONCOGENE BY THE P53 TUMOR-SUPPRESSOR". International Journal of Oncology 7, no. 5 (1995): 1029-1034. https://doi.org/10.3892/ijo.7.5.1029
Copy and paste a formatted citation
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Spandidos Publications style
SPANDIDOS D, ZOUMPOURLIS V, ZACHOS G, TOAS S and HALAZONETIS T: SPECIFIC RECOGNITION OF A TRANSCRIPTIONAL ELEMENT WITHIN THE HUMAN H-RAS PROTOONCOGENE BY THE P53 TUMOR-SUPPRESSOR. Int J Oncol 7: 1029-1034, 1995.
APA
SPANDIDOS, D., ZOUMPOURLIS, V., ZACHOS, G., TOAS, S., & HALAZONETIS, T. (1995). SPECIFIC RECOGNITION OF A TRANSCRIPTIONAL ELEMENT WITHIN THE HUMAN H-RAS PROTOONCOGENE BY THE P53 TUMOR-SUPPRESSOR. International Journal of Oncology, 7, 1029-1034. https://doi.org/10.3892/ijo.7.5.1029
MLA
SPANDIDOS, D., ZOUMPOURLIS, V., ZACHOS, G., TOAS, S., HALAZONETIS, T."SPECIFIC RECOGNITION OF A TRANSCRIPTIONAL ELEMENT WITHIN THE HUMAN H-RAS PROTOONCOGENE BY THE P53 TUMOR-SUPPRESSOR". International Journal of Oncology 7.5 (1995): 1029-1034.
Chicago
SPANDIDOS, D., ZOUMPOURLIS, V., ZACHOS, G., TOAS, S., HALAZONETIS, T."SPECIFIC RECOGNITION OF A TRANSCRIPTIONAL ELEMENT WITHIN THE HUMAN H-RAS PROTOONCOGENE BY THE P53 TUMOR-SUPPRESSOR". International Journal of Oncology 7, no. 5 (1995): 1029-1034. https://doi.org/10.3892/ijo.7.5.1029
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