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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 1995 Volume 7 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1995 Volume 7 Issue 5

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DEXNIGULDIPINE HYDROCHLORIDE INHIBITS GROWTH OF HUMAN HT-29 COLON-CARCINOMA CELLS AND EXPRESSION OF PROTEIN-KINASE-C-DELTA AND PROTEIN-KINASE-C-ZETA

  • Authors:
    • YF QIN
    • Y TANG
    • AV SCHALLY
    • BS BECKMAN

  • View Affiliations / Copyright

    Affiliations: TULANE UNIV,SCH MED,DEPT PHARMACOL,NEW ORLEANS,LA 70112. TULANE UNIV,SCH MED,DEPT MED,NEW ORLEANS,LA 70112. TULANE UNIV,SCH MED,TULANE CANC CTR,NEW ORLEANS,LA 70112.
  • Pages: 1073-1077
    |
    Published online on: November 1, 1995
       https://doi.org/10.3892/ijo.7.5.1073
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Abstract

Previous studies have implicated protein kinase C (PKC) in colon carcinogenesis, but a clear understanding of the role of PKC in colon cancer is lacking. The purpose of this study was to investigate the effects of dexniguldipine hydrochloride (DNIG) on the in vitro growth of HT-29 human colon carcinoma cells and the expression of PKC isoforms. DNIG is a selective inhibitor of PKC that binds specifically to the regulatory region and is also a potent antineoplastic drug with an ability to reverse multidrug resistance. DNIG (1.6-25 mu M) decreased the number of HT-29 cells in culture in a time- and dose-dependent manner with an EC(50) of 1.4 mu M on day 3. Predominant PKC isoforms expressed in HT-29 cells were identified as Delta and zeta by immunoblotting. The expression of PKC Delta and zeta was inhibited significantly by DNIG (0.16-1.25 mu M). These results suggest that the suppression of the growth of HT-29 colon carcinoma cells by DNIG involves the inhibition of the expression of PKC Delta and zeta.

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Copy and paste a formatted citation
Spandidos Publications style
QIN Y, TANG Y, SCHALLY A and BECKMAN B: DEXNIGULDIPINE HYDROCHLORIDE INHIBITS GROWTH OF HUMAN HT-29 COLON-CARCINOMA CELLS AND EXPRESSION OF PROTEIN-KINASE-C-DELTA AND PROTEIN-KINASE-C-ZETA. Int J Oncol 7: 1073-1077, 1995.
APA
QIN, Y., TANG, Y., SCHALLY, A., & BECKMAN, B. (1995). DEXNIGULDIPINE HYDROCHLORIDE INHIBITS GROWTH OF HUMAN HT-29 COLON-CARCINOMA CELLS AND EXPRESSION OF PROTEIN-KINASE-C-DELTA AND PROTEIN-KINASE-C-ZETA. International Journal of Oncology, 7, 1073-1077. https://doi.org/10.3892/ijo.7.5.1073
MLA
QIN, Y., TANG, Y., SCHALLY, A., BECKMAN, B."DEXNIGULDIPINE HYDROCHLORIDE INHIBITS GROWTH OF HUMAN HT-29 COLON-CARCINOMA CELLS AND EXPRESSION OF PROTEIN-KINASE-C-DELTA AND PROTEIN-KINASE-C-ZETA". International Journal of Oncology 7.5 (1995): 1073-1077.
Chicago
QIN, Y., TANG, Y., SCHALLY, A., BECKMAN, B."DEXNIGULDIPINE HYDROCHLORIDE INHIBITS GROWTH OF HUMAN HT-29 COLON-CARCINOMA CELLS AND EXPRESSION OF PROTEIN-KINASE-C-DELTA AND PROTEIN-KINASE-C-ZETA". International Journal of Oncology 7, no. 5 (1995): 1073-1077. https://doi.org/10.3892/ijo.7.5.1073
Copy and paste a formatted citation
x
Spandidos Publications style
QIN Y, TANG Y, SCHALLY A and BECKMAN B: DEXNIGULDIPINE HYDROCHLORIDE INHIBITS GROWTH OF HUMAN HT-29 COLON-CARCINOMA CELLS AND EXPRESSION OF PROTEIN-KINASE-C-DELTA AND PROTEIN-KINASE-C-ZETA. Int J Oncol 7: 1073-1077, 1995.
APA
QIN, Y., TANG, Y., SCHALLY, A., & BECKMAN, B. (1995). DEXNIGULDIPINE HYDROCHLORIDE INHIBITS GROWTH OF HUMAN HT-29 COLON-CARCINOMA CELLS AND EXPRESSION OF PROTEIN-KINASE-C-DELTA AND PROTEIN-KINASE-C-ZETA. International Journal of Oncology, 7, 1073-1077. https://doi.org/10.3892/ijo.7.5.1073
MLA
QIN, Y., TANG, Y., SCHALLY, A., BECKMAN, B."DEXNIGULDIPINE HYDROCHLORIDE INHIBITS GROWTH OF HUMAN HT-29 COLON-CARCINOMA CELLS AND EXPRESSION OF PROTEIN-KINASE-C-DELTA AND PROTEIN-KINASE-C-ZETA". International Journal of Oncology 7.5 (1995): 1073-1077.
Chicago
QIN, Y., TANG, Y., SCHALLY, A., BECKMAN, B."DEXNIGULDIPINE HYDROCHLORIDE INHIBITS GROWTH OF HUMAN HT-29 COLON-CARCINOMA CELLS AND EXPRESSION OF PROTEIN-KINASE-C-DELTA AND PROTEIN-KINASE-C-ZETA". International Journal of Oncology 7, no. 5 (1995): 1073-1077. https://doi.org/10.3892/ijo.7.5.1073
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