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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 1995 Volume 7 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 1995 Volume 7 Issue 5

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Article

INDUCTION OF TUMORIGENICITY BY GALECTIN-3 IN A NONTUMORIGENIC HUMAN BREAST-CARCINOMA CELL-LINE

  • Authors:
    • P NANGIAMAKKER
    • E THOMPSON
    • C HOGAN
    • J OCHIENG
    • A RAZ

  • View Affiliations / Copyright

    Affiliations: WAYNE STATE UNIV,SCH MED,KARMANOS CANC INST,DETROIT,MI 48201. WAYNE STATE UNIV,SCH MED,DEPT PATHOL,DETROIT,MI 48201. WAYNE STATE UNIV,SCH MED,DEPT RADIAT ONCOL,DETROIT,MI 48201. GEORGETOWN UNIV,MED CTR,LOMBARDI CANC RES CTR,DEPT CELL BIOL,WASHINGTON,DC 20001. GEORGETOWN UNIV,MED CTR,LOMBARDI CANC RES CTR,DEPT ORTHOPED SURG,WASHINGTON,DC 20001. MEHARRY MED COLL,SCH MED,DEPT BIOCHEM,NASHVILLE,TN 37208.
  • Pages: 1079-1087
    |
    Published online on: November 1, 1995
       https://doi.org/10.3892/ijo.7.5.1079
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Abstract

The human galectin-3 is a galactoside-binding protein of 31 kDa which functions as a receptor for glycoproteins containing poly N-acetyllactosamine side chains and as a substrate for matrix metalloproteinases-2 and -9. We studied its expression by flow cytoflourimetry, Western, Northern and Southern analyses, in five cultured human breast carcinoma cell lines previously characterized as nontumorigenic, poorly metastatic or metastatic in nude mice. The expression of galectin-3 correlated with the reported tumorigenicity of the cells. The introduction of recombinant galectin-3 into the null expressing non-tumorigenic BT-549 cells resulted in the acquisition of anchorage-independent growth properties in all and tumorigenicity in 3/4 sense transfected cell clones. The data indicate a relationship between galectin-3 expression and malignancy of human breast carcinoma cell lines.

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Copy and paste a formatted citation
Spandidos Publications style
NANGIAMAKKER P, THOMPSON E, HOGAN C, OCHIENG J and RAZ A: INDUCTION OF TUMORIGENICITY BY GALECTIN-3 IN A NONTUMORIGENIC HUMAN BREAST-CARCINOMA CELL-LINE. Int J Oncol 7: 1079-1087, 1995.
APA
NANGIAMAKKER, P., THOMPSON, E., HOGAN, C., OCHIENG, J., & RAZ, A. (1995). INDUCTION OF TUMORIGENICITY BY GALECTIN-3 IN A NONTUMORIGENIC HUMAN BREAST-CARCINOMA CELL-LINE. International Journal of Oncology, 7, 1079-1087. https://doi.org/10.3892/ijo.7.5.1079
MLA
NANGIAMAKKER, P., THOMPSON, E., HOGAN, C., OCHIENG, J., RAZ, A."INDUCTION OF TUMORIGENICITY BY GALECTIN-3 IN A NONTUMORIGENIC HUMAN BREAST-CARCINOMA CELL-LINE". International Journal of Oncology 7.5 (1995): 1079-1087.
Chicago
NANGIAMAKKER, P., THOMPSON, E., HOGAN, C., OCHIENG, J., RAZ, A."INDUCTION OF TUMORIGENICITY BY GALECTIN-3 IN A NONTUMORIGENIC HUMAN BREAST-CARCINOMA CELL-LINE". International Journal of Oncology 7, no. 5 (1995): 1079-1087. https://doi.org/10.3892/ijo.7.5.1079
Copy and paste a formatted citation
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Spandidos Publications style
NANGIAMAKKER P, THOMPSON E, HOGAN C, OCHIENG J and RAZ A: INDUCTION OF TUMORIGENICITY BY GALECTIN-3 IN A NONTUMORIGENIC HUMAN BREAST-CARCINOMA CELL-LINE. Int J Oncol 7: 1079-1087, 1995.
APA
NANGIAMAKKER, P., THOMPSON, E., HOGAN, C., OCHIENG, J., & RAZ, A. (1995). INDUCTION OF TUMORIGENICITY BY GALECTIN-3 IN A NONTUMORIGENIC HUMAN BREAST-CARCINOMA CELL-LINE. International Journal of Oncology, 7, 1079-1087. https://doi.org/10.3892/ijo.7.5.1079
MLA
NANGIAMAKKER, P., THOMPSON, E., HOGAN, C., OCHIENG, J., RAZ, A."INDUCTION OF TUMORIGENICITY BY GALECTIN-3 IN A NONTUMORIGENIC HUMAN BREAST-CARCINOMA CELL-LINE". International Journal of Oncology 7.5 (1995): 1079-1087.
Chicago
NANGIAMAKKER, P., THOMPSON, E., HOGAN, C., OCHIENG, J., RAZ, A."INDUCTION OF TUMORIGENICITY BY GALECTIN-3 IN A NONTUMORIGENIC HUMAN BREAST-CARCINOMA CELL-LINE". International Journal of Oncology 7, no. 5 (1995): 1079-1087. https://doi.org/10.3892/ijo.7.5.1079
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