STEROID-HORMONE PRODUCTION AND RECEPTORS IN RELATION TO KI-67, P53, S-PHASE FRACTION AND PLOIDY IN EPITHELIAL OVARIAN-TUMORS

  • Authors:
    • M RIDDERHEIM
    • B TRIBUKAIT
    • U STENDAHL
    • T BACKSTROM
    • S CAJANDER
  • View Affiliations

  • Published online on: November 1, 1995     https://doi.org/10.3892/ijo.7.5.1095
  • Pages: 1095-1102
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Abstract

In this investigation, the in vitro production of progesterone and estradiol in ovarian tissues was studied for the first time in relation to the immunohistochemical expression of steroid hormone receptors, Ki-67, p53, DNA ploidy and S-phase fraction. Ovarian tissue from 44 women was examined. Steroid receptors were found more frequently in normal than in tumor ovaries. A substantial focal staining heterogeneity was demonstrated. Mucinous tumors were always progesterone receptor negative. Furthermore, the Ki-67 index was negatively correlated to the progesterone production of the tumor ovaries. Among the malignant tumors, all the high producers of progesterone expressing PR were low proliferating, diploid and p53-negative.

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November 1995
Volume 7 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
RIDDERHEIM M, TRIBUKAIT B, STENDAHL U, BACKSTROM T and CAJANDER S: STEROID-HORMONE PRODUCTION AND RECEPTORS IN RELATION TO KI-67, P53, S-PHASE FRACTION AND PLOIDY IN EPITHELIAL OVARIAN-TUMORS. Int J Oncol 7: 1095-1102, 1995
APA
RIDDERHEIM, M., TRIBUKAIT, B., STENDAHL, U., BACKSTROM, T., & CAJANDER, S. (1995). STEROID-HORMONE PRODUCTION AND RECEPTORS IN RELATION TO KI-67, P53, S-PHASE FRACTION AND PLOIDY IN EPITHELIAL OVARIAN-TUMORS. International Journal of Oncology, 7, 1095-1102. https://doi.org/10.3892/ijo.7.5.1095
MLA
RIDDERHEIM, M., TRIBUKAIT, B., STENDAHL, U., BACKSTROM, T., CAJANDER, S."STEROID-HORMONE PRODUCTION AND RECEPTORS IN RELATION TO KI-67, P53, S-PHASE FRACTION AND PLOIDY IN EPITHELIAL OVARIAN-TUMORS". International Journal of Oncology 7.5 (1995): 1095-1102.
Chicago
RIDDERHEIM, M., TRIBUKAIT, B., STENDAHL, U., BACKSTROM, T., CAJANDER, S."STEROID-HORMONE PRODUCTION AND RECEPTORS IN RELATION TO KI-67, P53, S-PHASE FRACTION AND PLOIDY IN EPITHELIAL OVARIAN-TUMORS". International Journal of Oncology 7, no. 5 (1995): 1095-1102. https://doi.org/10.3892/ijo.7.5.1095