A ROLE FOR HISTAMINE IN HUMAN-MALIGNANT GLIOMA-CELLS

  • Authors:
    • M HIROHATA
    • Y SASAGURI
    • M SHIGEMORI
    • H MARUIWA
    • M MORIMATSU
  • View Affiliations

  • Published online on: November 1, 1995     https://doi.org/10.3892/ijo.7.5.1109
  • Pages: 1109-1115
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Abstract

Histaminergic neuron cells send fiber terminals to almost all parts of the brain, and the histamine receptors on astrocytes are the main targets of central histaminergic neurons. But no proof of the significance of histamine and its specific receptors on human malignant astrocytoma cells has been presented to date. Our results show that six malignant glioma cell lines used in this experiment secreted histamine into the culture medium and that the histamine stimulated their DNA synthesis in a dose-dependent manner. Moreover, histamine induced accumulation of inositol triphosphate (IP3) in all cell lines in either a time- or a dose-dependent manner, whereas cAMP accumulation was not induced by it in any of these cell lines, indicating that these cell lines express the H-1-receptors but not the H-2-receptors. In vivo, thus, malignant glioma may possibly produce histamine, which then would stimulate their neoplastic behavior mediated by the H-1-receptor.

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November 1995
Volume 7 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
HIROHATA M, SASAGURI Y, SHIGEMORI M, MARUIWA H and MORIMATSU M: A ROLE FOR HISTAMINE IN HUMAN-MALIGNANT GLIOMA-CELLS. Int J Oncol 7: 1109-1115, 1995
APA
HIROHATA, M., SASAGURI, Y., SHIGEMORI, M., MARUIWA, H., & MORIMATSU, M. (1995). A ROLE FOR HISTAMINE IN HUMAN-MALIGNANT GLIOMA-CELLS. International Journal of Oncology, 7, 1109-1115. https://doi.org/10.3892/ijo.7.5.1109
MLA
HIROHATA, M., SASAGURI, Y., SHIGEMORI, M., MARUIWA, H., MORIMATSU, M."A ROLE FOR HISTAMINE IN HUMAN-MALIGNANT GLIOMA-CELLS". International Journal of Oncology 7.5 (1995): 1109-1115.
Chicago
HIROHATA, M., SASAGURI, Y., SHIGEMORI, M., MARUIWA, H., MORIMATSU, M."A ROLE FOR HISTAMINE IN HUMAN-MALIGNANT GLIOMA-CELLS". International Journal of Oncology 7, no. 5 (1995): 1109-1115. https://doi.org/10.3892/ijo.7.5.1109