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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 1995 Volume 7 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November 1995 Volume 7 Issue 5

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Article

A ROLE FOR HISTAMINE IN HUMAN-MALIGNANT GLIOMA-CELLS

  • Authors:
    • M HIROHATA
    • Y SASAGURI
    • M SHIGEMORI
    • H MARUIWA
    • M MORIMATSU

  • View Affiliations / Copyright

    Affiliations: UNIV OCCUPAT & ENVIRONM HLTH, SCH MED, DEPT PATHOL, YAHATANISHI KU, KITAKYUSHU, FUKUOKA 807, JAPAN. KURUME UNIV, SCH MED, DEPT PATHOL, KURUME, FUKUOKA 830, JAPAN. KURUME UNIV, SCH MED, DEPT NEUROSURG, KURUME, FUKUOKA 830, JAPAN.
  • Pages: 1109-1115
    |
    Published online on: November 1, 1995
       https://doi.org/10.3892/ijo.7.5.1109
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Abstract

Histaminergic neuron cells send fiber terminals to almost all parts of the brain, and the histamine receptors on astrocytes are the main targets of central histaminergic neurons. But no proof of the significance of histamine and its specific receptors on human malignant astrocytoma cells has been presented to date. Our results show that six malignant glioma cell lines used in this experiment secreted histamine into the culture medium and that the histamine stimulated their DNA synthesis in a dose-dependent manner. Moreover, histamine induced accumulation of inositol triphosphate (IP3) in all cell lines in either a time- or a dose-dependent manner, whereas cAMP accumulation was not induced by it in any of these cell lines, indicating that these cell lines express the H-1-receptors but not the H-2-receptors. In vivo, thus, malignant glioma may possibly produce histamine, which then would stimulate their neoplastic behavior mediated by the H-1-receptor.

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Copy and paste a formatted citation
Spandidos Publications style
HIROHATA M, SASAGURI Y, SHIGEMORI M, MARUIWA H and MORIMATSU M: A ROLE FOR HISTAMINE IN HUMAN-MALIGNANT GLIOMA-CELLS. Int J Oncol 7: 1109-1115, 1995.
APA
HIROHATA, M., SASAGURI, Y., SHIGEMORI, M., MARUIWA, H., & MORIMATSU, M. (1995). A ROLE FOR HISTAMINE IN HUMAN-MALIGNANT GLIOMA-CELLS. International Journal of Oncology, 7, 1109-1115. https://doi.org/10.3892/ijo.7.5.1109
MLA
HIROHATA, M., SASAGURI, Y., SHIGEMORI, M., MARUIWA, H., MORIMATSU, M."A ROLE FOR HISTAMINE IN HUMAN-MALIGNANT GLIOMA-CELLS". International Journal of Oncology 7.5 (1995): 1109-1115.
Chicago
HIROHATA, M., SASAGURI, Y., SHIGEMORI, M., MARUIWA, H., MORIMATSU, M."A ROLE FOR HISTAMINE IN HUMAN-MALIGNANT GLIOMA-CELLS". International Journal of Oncology 7, no. 5 (1995): 1109-1115. https://doi.org/10.3892/ijo.7.5.1109
Copy and paste a formatted citation
x
Spandidos Publications style
HIROHATA M, SASAGURI Y, SHIGEMORI M, MARUIWA H and MORIMATSU M: A ROLE FOR HISTAMINE IN HUMAN-MALIGNANT GLIOMA-CELLS. Int J Oncol 7: 1109-1115, 1995.
APA
HIROHATA, M., SASAGURI, Y., SHIGEMORI, M., MARUIWA, H., & MORIMATSU, M. (1995). A ROLE FOR HISTAMINE IN HUMAN-MALIGNANT GLIOMA-CELLS. International Journal of Oncology, 7, 1109-1115. https://doi.org/10.3892/ijo.7.5.1109
MLA
HIROHATA, M., SASAGURI, Y., SHIGEMORI, M., MARUIWA, H., MORIMATSU, M."A ROLE FOR HISTAMINE IN HUMAN-MALIGNANT GLIOMA-CELLS". International Journal of Oncology 7.5 (1995): 1109-1115.
Chicago
HIROHATA, M., SASAGURI, Y., SHIGEMORI, M., MARUIWA, H., MORIMATSU, M."A ROLE FOR HISTAMINE IN HUMAN-MALIGNANT GLIOMA-CELLS". International Journal of Oncology 7, no. 5 (1995): 1109-1115. https://doi.org/10.3892/ijo.7.5.1109
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