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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 1995 Volume 7 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 1995 Volume 7 Issue 6

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Article

INCREASED EXPRESSION OF BCL-2 IN DRUG-RESISTANT SQUAMOUS-CELL LUNG CARCINOMAS

  • Authors:
    • M VOLM
    • J MATTERN
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    Affiliations: Affliations not specified
  • Pages: 1333-1338
    |
    Published online on: December 1, 1995
       https://doi.org/10.3892/ijo.7.6.1333
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Abstract

The aim of this investigation was to prove whether or not an association exists between Bcl-2 expression and in vitro resistance to doxorubicin in biopsies of 85 human squamous cell lung carcinomas. Additionally, the relationship of Bcl-2 expression with resistance related proteins (P-glycoprotein, glutathione S-transferase-pi, catalase) was analyzed. Of the 85 carcinomas, 17 (20%) revealed Bcl-2 expression by immunohistochemistry. Seventeen of the tumors were classified as sensitive and 68 as resistant by an in vitro predictive test. All 17 Bcl-2-positive carcinomas were resistant to doxorubicin (p=0.018; chi(2)-test). A correlation was found between expression of Bcl-2 and expression of the resistance-related proteins P-glycoprotein and glutathione S-transferase-pi. The median survival time for patients with Bcl-2-negative carcinomas was two years and for Bcl-2-positive tumors over six years (log-rank test; p=0.08). Multivariate analysis (Cox regression model) revealed a borderline significant influence of Bcl-2 (p=0.07), whereas all other clinical factors (age, stage, metastasis) were of no significant influence on survival.

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Copy and paste a formatted citation
Spandidos Publications style
VOLM M and MATTERN J: INCREASED EXPRESSION OF BCL-2 IN DRUG-RESISTANT SQUAMOUS-CELL LUNG CARCINOMAS. Int J Oncol 7: 1333-1338, 1995.
APA
VOLM, M., & MATTERN, J. (1995). INCREASED EXPRESSION OF BCL-2 IN DRUG-RESISTANT SQUAMOUS-CELL LUNG CARCINOMAS. International Journal of Oncology, 7, 1333-1338. https://doi.org/10.3892/ijo.7.6.1333
MLA
VOLM, M., MATTERN, J."INCREASED EXPRESSION OF BCL-2 IN DRUG-RESISTANT SQUAMOUS-CELL LUNG CARCINOMAS". International Journal of Oncology 7.6 (1995): 1333-1338.
Chicago
VOLM, M., MATTERN, J."INCREASED EXPRESSION OF BCL-2 IN DRUG-RESISTANT SQUAMOUS-CELL LUNG CARCINOMAS". International Journal of Oncology 7, no. 6 (1995): 1333-1338. https://doi.org/10.3892/ijo.7.6.1333
Copy and paste a formatted citation
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Spandidos Publications style
VOLM M and MATTERN J: INCREASED EXPRESSION OF BCL-2 IN DRUG-RESISTANT SQUAMOUS-CELL LUNG CARCINOMAS. Int J Oncol 7: 1333-1338, 1995.
APA
VOLM, M., & MATTERN, J. (1995). INCREASED EXPRESSION OF BCL-2 IN DRUG-RESISTANT SQUAMOUS-CELL LUNG CARCINOMAS. International Journal of Oncology, 7, 1333-1338. https://doi.org/10.3892/ijo.7.6.1333
MLA
VOLM, M., MATTERN, J."INCREASED EXPRESSION OF BCL-2 IN DRUG-RESISTANT SQUAMOUS-CELL LUNG CARCINOMAS". International Journal of Oncology 7.6 (1995): 1333-1338.
Chicago
VOLM, M., MATTERN, J."INCREASED EXPRESSION OF BCL-2 IN DRUG-RESISTANT SQUAMOUS-CELL LUNG CARCINOMAS". International Journal of Oncology 7, no. 6 (1995): 1333-1338. https://doi.org/10.3892/ijo.7.6.1333
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