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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 1995 Volume 7 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 1995 Volume 7 Issue 6

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Article

BIOCHEMICAL MODULATION OF DOXORUBICIN USING AN ISOPRENOID DERIVATIVE, N-1379 - PLASMA TRANSMEMBRANE POTENTIAL AS A TARGET SITE

  • Authors:
    • K AOGI
    • M NISHIYAMA
    • S SAEKI
    • N HIRABAYASHI
    • T TOGE

  • View Affiliations / Copyright

    Affiliations: Affliations not specified
  • Pages: 1395-1399
    |
    Published online on: December 1, 1995
       https://doi.org/10.3892/ijo.7.6.1395
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Abstract

A new isoprenoid derivative, N-1379, was evaluated as a modulating agent of doxorubicin (DOX)-induced anticancer efficacy. The level of plasma transmembrane potential, measured using DiOC6(3), correlated with cellular sensitivity to DOX in K562 myelogenous leukemia, SH101 stomach, and PH101 pancreatic cancer cells. Non-toxic N-1379 increased the cellular transmembrane potential and DOX efficacy for three cell lines. The modulation of membrane function was accompanied by increases of DOX accumulation and S/G(2)M phase population in these cells. Overexpression of a 170 kD plasma membrane glycoprotein (GP-170) was not observed in any cells examined. We suggest therefore that interaction between electronegative transmembrane potential and positive charge of DOX may be linked to intracellular DOX accumulation. N-1379 may augment DOX efficacy through its increasing effect on plasma membrane potential independently of GP-170 overexpression.

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Copy and paste a formatted citation
Spandidos Publications style
AOGI K, NISHIYAMA M, SAEKI S, HIRABAYASHI N and TOGE T: BIOCHEMICAL MODULATION OF DOXORUBICIN USING AN ISOPRENOID DERIVATIVE, N-1379 - PLASMA TRANSMEMBRANE POTENTIAL AS A TARGET SITE. Int J Oncol 7: 1395-1399, 1995.
APA
AOGI, K., NISHIYAMA, M., SAEKI, S., HIRABAYASHI, N., & TOGE, T. (1995). BIOCHEMICAL MODULATION OF DOXORUBICIN USING AN ISOPRENOID DERIVATIVE, N-1379 - PLASMA TRANSMEMBRANE POTENTIAL AS A TARGET SITE. International Journal of Oncology, 7, 1395-1399. https://doi.org/10.3892/ijo.7.6.1395
MLA
AOGI, K., NISHIYAMA, M., SAEKI, S., HIRABAYASHI, N., TOGE, T."BIOCHEMICAL MODULATION OF DOXORUBICIN USING AN ISOPRENOID DERIVATIVE, N-1379 - PLASMA TRANSMEMBRANE POTENTIAL AS A TARGET SITE". International Journal of Oncology 7.6 (1995): 1395-1399.
Chicago
AOGI, K., NISHIYAMA, M., SAEKI, S., HIRABAYASHI, N., TOGE, T."BIOCHEMICAL MODULATION OF DOXORUBICIN USING AN ISOPRENOID DERIVATIVE, N-1379 - PLASMA TRANSMEMBRANE POTENTIAL AS A TARGET SITE". International Journal of Oncology 7, no. 6 (1995): 1395-1399. https://doi.org/10.3892/ijo.7.6.1395
Copy and paste a formatted citation
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Spandidos Publications style
AOGI K, NISHIYAMA M, SAEKI S, HIRABAYASHI N and TOGE T: BIOCHEMICAL MODULATION OF DOXORUBICIN USING AN ISOPRENOID DERIVATIVE, N-1379 - PLASMA TRANSMEMBRANE POTENTIAL AS A TARGET SITE. Int J Oncol 7: 1395-1399, 1995.
APA
AOGI, K., NISHIYAMA, M., SAEKI, S., HIRABAYASHI, N., & TOGE, T. (1995). BIOCHEMICAL MODULATION OF DOXORUBICIN USING AN ISOPRENOID DERIVATIVE, N-1379 - PLASMA TRANSMEMBRANE POTENTIAL AS A TARGET SITE. International Journal of Oncology, 7, 1395-1399. https://doi.org/10.3892/ijo.7.6.1395
MLA
AOGI, K., NISHIYAMA, M., SAEKI, S., HIRABAYASHI, N., TOGE, T."BIOCHEMICAL MODULATION OF DOXORUBICIN USING AN ISOPRENOID DERIVATIVE, N-1379 - PLASMA TRANSMEMBRANE POTENTIAL AS A TARGET SITE". International Journal of Oncology 7.6 (1995): 1395-1399.
Chicago
AOGI, K., NISHIYAMA, M., SAEKI, S., HIRABAYASHI, N., TOGE, T."BIOCHEMICAL MODULATION OF DOXORUBICIN USING AN ISOPRENOID DERIVATIVE, N-1379 - PLASMA TRANSMEMBRANE POTENTIAL AS A TARGET SITE". International Journal of Oncology 7, no. 6 (1995): 1395-1399. https://doi.org/10.3892/ijo.7.6.1395
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