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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 1996 Volume 8 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 1996 Volume 8 Issue 1

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Article

Resistance to tumor necrosis factor-induced apoptosis in mouse fibroblasts is a genetically dominant phenotype

  • Authors:
    • A Fernandez
    • D McConkey
    • H Ananthaswamy

  • View Affiliations / Copyright

    Affiliations: UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT IMMUNOL,HOUSTON,TX 77030. UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT CELL BIOL,HOUSTON,TX 77030.
  • Pages: 169-173
    |
    Published online on: January 1, 1996
       https://doi.org/10.3892/ijo.8.1.169
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Abstract

Although many tumor cells are sensitive to tumor necrosis factor (TNF)-induced cell death, most normal cells are resistant. To determine whether the sensitive phenotype or the resistant phenotype is genetically dominant, we constructed somatic cell hybrids of TNF-resistant (TNP) C3H mouse 10T1/2 fibroblasts and Ha-ms-transformed TNF-sensitive (TNFs) 10T-EJ cells and then tested the sensitivity of those hybrids to TNF-induced cell death. All somatic cell hybrid cell lines tested were resistant to TNF-induced cell death. The TNFr 10T1/2 cells, however, exhibited sensitivity to TNF-induced cell death in the presence of cycloheximide (CHX), whereas TNFs 10T-EJ cells did not show any further increase in sensitivity to TNF-induced cell death in the presence of CHX. In addition, the killing of 1OT1/2 cells by TNF in the presence of CHX involved apoptosis. These results demonstrate that resistance to TNF-induced apoptosis is a genetically dominant phenotype and that certain protein(s) constitutively expressed or induced by TNF in resistant cells may confer protection against TNF-induced apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Fernandez A, McConkey D and Ananthaswamy H: Resistance to tumor necrosis factor-induced apoptosis in mouse fibroblasts is a genetically dominant phenotype. Int J Oncol 8: 169-173, 1996.
APA
Fernandez, A., McConkey, D., & Ananthaswamy, H. (1996). Resistance to tumor necrosis factor-induced apoptosis in mouse fibroblasts is a genetically dominant phenotype. International Journal of Oncology, 8, 169-173. https://doi.org/10.3892/ijo.8.1.169
MLA
Fernandez, A., McConkey, D., Ananthaswamy, H."Resistance to tumor necrosis factor-induced apoptosis in mouse fibroblasts is a genetically dominant phenotype". International Journal of Oncology 8.1 (1996): 169-173.
Chicago
Fernandez, A., McConkey, D., Ananthaswamy, H."Resistance to tumor necrosis factor-induced apoptosis in mouse fibroblasts is a genetically dominant phenotype". International Journal of Oncology 8, no. 1 (1996): 169-173. https://doi.org/10.3892/ijo.8.1.169
Copy and paste a formatted citation
x
Spandidos Publications style
Fernandez A, McConkey D and Ananthaswamy H: Resistance to tumor necrosis factor-induced apoptosis in mouse fibroblasts is a genetically dominant phenotype. Int J Oncol 8: 169-173, 1996.
APA
Fernandez, A., McConkey, D., & Ananthaswamy, H. (1996). Resistance to tumor necrosis factor-induced apoptosis in mouse fibroblasts is a genetically dominant phenotype. International Journal of Oncology, 8, 169-173. https://doi.org/10.3892/ijo.8.1.169
MLA
Fernandez, A., McConkey, D., Ananthaswamy, H."Resistance to tumor necrosis factor-induced apoptosis in mouse fibroblasts is a genetically dominant phenotype". International Journal of Oncology 8.1 (1996): 169-173.
Chicago
Fernandez, A., McConkey, D., Ananthaswamy, H."Resistance to tumor necrosis factor-induced apoptosis in mouse fibroblasts is a genetically dominant phenotype". International Journal of Oncology 8, no. 1 (1996): 169-173. https://doi.org/10.3892/ijo.8.1.169
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