Expression of mRNA for gelatinase A and TIMP-2 in cell cultures and tissue samples derived from breast and lung carcinomas

Fassina,G; Paglialunga,G; Fontanini,G; Cosimi,A; Perrotta,A; Aluigi,M; Ardizzoni,A; Albini,A

doi:10.3892/ijo.8.2.253

February 1996 Volume 8 Issue 2

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February 1996 Volume 8 Issue 2

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Article

Expression of mRNA for gelatinase A and TIMP-2 in cell cultures and tissue samples derived from breast and lung carcinomas

Authors:
- G Fassina
- G Paglialunga
- G Fontanini
- A Cosimi
- A Perrotta
- M Aluigi
- A Ardizzoni
- A Albini
View Affiliations / Copyright

Affiliations: CNR,CTR STUDIO NEUROFISIOL CEREBRALE,I-16132 GENOA,ITALY. UNIV PISA,IST ANAT PATOL,I-56100 PISA,ITALY. OSPED RIUNITI LIVORNO,UNITA OPERAT ANAT PATOL & CITOPATOL,I-57100 LIVORNO,ITALY.
Pages: 253-261
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Published online on: February 1, 1996

https://doi.org/10.3892/ijo.8.2.253
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Abstract

The aim of this study was to determine how closely expression of MMP-2 and TIMP-2 is associated with poor patient prognosis in breast and lung cancer. mRNA levels of MMP-2 and TIMP-2 were examined on dot blots in 34 cases of human breast carcinoma and in 13 cases of lung carcinoma. In breast carcinomas we found that high MMP-2 and/or low TIMP-2 expression did not consistently correspond to a poor clinical situation, while high MMP-2/TIMP-2 ratios were also found in subjects whose clinical status was relatively favorable. Statistical analysis did not show any significant association between MMP-2/TIMP-2 and the tumor markers examined. Regarding lung carcinomas, we did not find a correlation between the ratio and poor prognosis, whereas in lung carcinoma cells in vitro we found an enhancement in MMP-2 production. A possible explanation for these results is that in vivo, as opposed to in vitro, it appears that the stromal cells of the tumor and not the tumor cell itself, produce MMP-2.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression of mRNA for gelatinase A and TIMP-2 in cell cultures and tissue samples derived from breast and lung carcinomas

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Abstract

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