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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
March 1996 Volume 8 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 1996 Volume 8 Issue 3

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Article

Sensitization of AIDS related non-Hodgkin's B lymphoma cell lines to cytotoxic drugs toxins by interferon-gamma

  • Authors:
    • A Demidem
    • Z Salahuddin
    • T Lam
    • A Levine
    • R Khan
    • D Hober
    • B Bonavida

  • View Affiliations / Copyright

    Affiliations: UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90024. UNIV CALIF LOS ANGELES,JONSSON COMPREHENS CANC CTR,LOS ANGELES,CA 90024. HUNTINGTON MEM HOSP,INST MOLEC MED & TECHNOL,PASADENA,CA 91105. SERV BACTERIOL VIROL B,F-59037 LILLE,FRANCE. UNIV SO CALIF,NORRIS CANC REGISTRY,SCH MED,LOS ANGELES,CA 90089.
  • Pages: 461-468
    |
    Published online on: March 1, 1996
       https://doi.org/10.3892/ijo.8.3.461
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Abstract

AIDS-related lymphomas (ARL) progressively become resistant to conventional chemotherapy. We have developed three B cell lines from tumor biopsies of AIDS patients with non-Hodgkin's lymphoma (NHL). The ARL cell lines were shown to be resistant to a panel of cytotoxic cytokines, toxins and drugs such as tumor necrosis factor, diphteria toxin, ricin, adriamycin, cis-platinum and anti-Fas antibody. However, when these cell lines were pretreated with low concentrations of interferon-gamma (IFN-gamma), (50 U/ml or 150 U/ml) for 24 to 48 h, the tumor cells became sensitive to these cytotoxic agents. Pretreatment of ARL with IFN-gamma stimulated proliferation while IFN-gamma inhibited the growth of ovarian tumor cell lines. Further, following treatment with IFN-gamma, the secretion of TNF-alpha by ARL lines was significantly decreased and TNF-alpha surface receptor expression was downregulated. The expression of several surface antigens on ARL was upregulated by IFN-gamma. These findings demonstrate that treatment of ARL with IFN-gamma stimulated cell proliferation, modulated several surface antigens, inhibited TNF-alpha secretion and sensitized the tumor cells to cytotoxicity by various drugs/toxins. These findings may be clinically relevant in the treatment of drug-refractory ARL.

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Copy and paste a formatted citation
Spandidos Publications style
Demidem A, Salahuddin Z, Lam T, Levine A, Khan R, Hober D and Bonavida B: Sensitization of AIDS related non-Hodgkin's B lymphoma cell lines to cytotoxic drugs toxins by interferon-gamma. Int J Oncol 8: 461-468, 1996.
APA
Demidem, A., Salahuddin, Z., Lam, T., Levine, A., Khan, R., Hober, D., & Bonavida, B. (1996). Sensitization of AIDS related non-Hodgkin's B lymphoma cell lines to cytotoxic drugs toxins by interferon-gamma. International Journal of Oncology, 8, 461-468. https://doi.org/10.3892/ijo.8.3.461
MLA
Demidem, A., Salahuddin, Z., Lam, T., Levine, A., Khan, R., Hober, D., Bonavida, B."Sensitization of AIDS related non-Hodgkin's B lymphoma cell lines to cytotoxic drugs toxins by interferon-gamma". International Journal of Oncology 8.3 (1996): 461-468.
Chicago
Demidem, A., Salahuddin, Z., Lam, T., Levine, A., Khan, R., Hober, D., Bonavida, B."Sensitization of AIDS related non-Hodgkin's B lymphoma cell lines to cytotoxic drugs toxins by interferon-gamma". International Journal of Oncology 8, no. 3 (1996): 461-468. https://doi.org/10.3892/ijo.8.3.461
Copy and paste a formatted citation
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Spandidos Publications style
Demidem A, Salahuddin Z, Lam T, Levine A, Khan R, Hober D and Bonavida B: Sensitization of AIDS related non-Hodgkin's B lymphoma cell lines to cytotoxic drugs toxins by interferon-gamma. Int J Oncol 8: 461-468, 1996.
APA
Demidem, A., Salahuddin, Z., Lam, T., Levine, A., Khan, R., Hober, D., & Bonavida, B. (1996). Sensitization of AIDS related non-Hodgkin's B lymphoma cell lines to cytotoxic drugs toxins by interferon-gamma. International Journal of Oncology, 8, 461-468. https://doi.org/10.3892/ijo.8.3.461
MLA
Demidem, A., Salahuddin, Z., Lam, T., Levine, A., Khan, R., Hober, D., Bonavida, B."Sensitization of AIDS related non-Hodgkin's B lymphoma cell lines to cytotoxic drugs toxins by interferon-gamma". International Journal of Oncology 8.3 (1996): 461-468.
Chicago
Demidem, A., Salahuddin, Z., Lam, T., Levine, A., Khan, R., Hober, D., Bonavida, B."Sensitization of AIDS related non-Hodgkin's B lymphoma cell lines to cytotoxic drugs toxins by interferon-gamma". International Journal of Oncology 8, no. 3 (1996): 461-468. https://doi.org/10.3892/ijo.8.3.461
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