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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 1996 Volume 8 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 1996 Volume 8 Issue 5

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Article

Stilbene estrogen-mediated enhanced tyrosine phosphorylation of the nuclear protein p53 by nuclear matrix associated tyrosine kinase(s)

  • Authors:
    • M Palangat
    • D Roy

  • View Affiliations / Copyright

    Affiliations: UNIV ALABAMA,DEPT ENVIRONM HLTH SCI,ENVIRONM TOXICOL PROGRAM,BIRMINGHAM,AL 35294.
  • Pages: 1011-1016
    |
    Published online on: May 1, 1996
       https://doi.org/10.3892/ijo.8.5.1011
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Abstract

We have previously shown that protein tyrosine kinases are present in the nuclei of hamster renal epithelial cells. In this study we have identified an endogenous, critically important nuclear matrix protein as a substrate for tyrosine phosphorylation by nuclear matrix tyrosine kinases (NM-PTKs) and its modulation by stilbene estrogen, diethylstilbestrol (DES). Analyses of tyrosine phosphorylation of nuclear matrix proteins by endogenous labeling revealed that NM-PTKs were able to phosphorylate the tyrosine residues of several proteins. Both amino acid analysis and immuno-precipitation of nuclear matrix proteins with the monoclonal antibody that recognizes wild-type p53 revealed that p53 was phosphorylated on its tyrosine residues by NM-PTK(s). Moreover, DES exposure resulted in the enhanced tyrosine phosphorylation of p53 to a tune of 3.6 fold. Several other proteins of the nuclear matrix were also differentially phosphorylated in response to DES exposure. The DES-mediated enhanced tyrosine phosphorylation of p53 coincided with increased cell proliferation of renal tubular epithelial cells of Syrian hamster. The results of this study suggest that p53 protein is phosphorylated at tyrosine residues and enhanced tyrosine phosphorylation of p53 by DES exposure may play a role in the proliferation of hamster renal tubular epithelial cells.

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Copy and paste a formatted citation
Spandidos Publications style
Palangat M and Roy D: Stilbene estrogen-mediated enhanced tyrosine phosphorylation of the nuclear protein p53 by nuclear matrix associated tyrosine kinase(s). Int J Oncol 8: 1011-1016, 1996.
APA
Palangat, M., & Roy, D. (1996). Stilbene estrogen-mediated enhanced tyrosine phosphorylation of the nuclear protein p53 by nuclear matrix associated tyrosine kinase(s). International Journal of Oncology, 8, 1011-1016. https://doi.org/10.3892/ijo.8.5.1011
MLA
Palangat, M., Roy, D."Stilbene estrogen-mediated enhanced tyrosine phosphorylation of the nuclear protein p53 by nuclear matrix associated tyrosine kinase(s)". International Journal of Oncology 8.5 (1996): 1011-1016.
Chicago
Palangat, M., Roy, D."Stilbene estrogen-mediated enhanced tyrosine phosphorylation of the nuclear protein p53 by nuclear matrix associated tyrosine kinase(s)". International Journal of Oncology 8, no. 5 (1996): 1011-1016. https://doi.org/10.3892/ijo.8.5.1011
Copy and paste a formatted citation
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Spandidos Publications style
Palangat M and Roy D: Stilbene estrogen-mediated enhanced tyrosine phosphorylation of the nuclear protein p53 by nuclear matrix associated tyrosine kinase(s). Int J Oncol 8: 1011-1016, 1996.
APA
Palangat, M., & Roy, D. (1996). Stilbene estrogen-mediated enhanced tyrosine phosphorylation of the nuclear protein p53 by nuclear matrix associated tyrosine kinase(s). International Journal of Oncology, 8, 1011-1016. https://doi.org/10.3892/ijo.8.5.1011
MLA
Palangat, M., Roy, D."Stilbene estrogen-mediated enhanced tyrosine phosphorylation of the nuclear protein p53 by nuclear matrix associated tyrosine kinase(s)". International Journal of Oncology 8.5 (1996): 1011-1016.
Chicago
Palangat, M., Roy, D."Stilbene estrogen-mediated enhanced tyrosine phosphorylation of the nuclear protein p53 by nuclear matrix associated tyrosine kinase(s)". International Journal of Oncology 8, no. 5 (1996): 1011-1016. https://doi.org/10.3892/ijo.8.5.1011
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