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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 1996 Volume 8 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 1996 Volume 8 Issue 5

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Article

HER-2/neu in bladder carcinoma

  • Authors:
    • S Tommasi
    • P Ditonno
    • M Sisto
    • A Paradiso
    • A Gentile
    • R Ricco
    • F Schittulli
    • U Jacobellis
  • View Affiliations / Copyright

    Affiliations: POLICLIN BARI,DEPT UROL,BARI,ITALY. UNIV BARI,INST PATHOL,BARI,ITALY.
  • Pages: 957-961
    |
    Published online on: May 1, 1996
       https://doi.org/10.3892/ijo.8.5.957
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Abstract

A total of 66 bladder cancer patients were studied to verify possible relationships between HER-2/neu alterations and pathological characteristics, and to define a poor prognosis patient subgroup with respect to time to recurrence, time to progression and survival. Tumor and healthy tissue specimens were analyzed for HER-2/neu DNA amplification and protein overexpression by Southern and Western blot techniques and evaluated statistically. 13% of cases were amplified and 39% were overexpressed. HER-2/neu alterations were not significantly associated with pathological staging or tumor grading. Multifocal tumors had a higher percentage and overexpression with respect to monofocal tumors. Actuarial analyses did not show a significant statistical correlation between HER-2/neu amplification and overexpression and clinical outcome. Clinical evaluation of HER-2/neu status showed that this gene is not related to tumor relapse, progression or patient survival.

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Copy and paste a formatted citation
Spandidos Publications style
Tommasi S, Ditonno P, Sisto M, Paradiso A, Gentile A, Ricco R, Schittulli F and Jacobellis U: HER-2/neu in bladder carcinoma. Int J Oncol 8: 957-961, 1996.
APA
Tommasi, S., Ditonno, P., Sisto, M., Paradiso, A., Gentile, A., Ricco, R. ... Jacobellis, U. (1996). HER-2/neu in bladder carcinoma. International Journal of Oncology, 8, 957-961. https://doi.org/10.3892/ijo.8.5.957
MLA
Tommasi, S., Ditonno, P., Sisto, M., Paradiso, A., Gentile, A., Ricco, R., Schittulli, F., Jacobellis, U."HER-2/neu in bladder carcinoma". International Journal of Oncology 8.5 (1996): 957-961.
Chicago
Tommasi, S., Ditonno, P., Sisto, M., Paradiso, A., Gentile, A., Ricco, R., Schittulli, F., Jacobellis, U."HER-2/neu in bladder carcinoma". International Journal of Oncology 8, no. 5 (1996): 957-961. https://doi.org/10.3892/ijo.8.5.957
Copy and paste a formatted citation
x
Spandidos Publications style
Tommasi S, Ditonno P, Sisto M, Paradiso A, Gentile A, Ricco R, Schittulli F and Jacobellis U: HER-2/neu in bladder carcinoma. Int J Oncol 8: 957-961, 1996.
APA
Tommasi, S., Ditonno, P., Sisto, M., Paradiso, A., Gentile, A., Ricco, R. ... Jacobellis, U. (1996). HER-2/neu in bladder carcinoma. International Journal of Oncology, 8, 957-961. https://doi.org/10.3892/ijo.8.5.957
MLA
Tommasi, S., Ditonno, P., Sisto, M., Paradiso, A., Gentile, A., Ricco, R., Schittulli, F., Jacobellis, U."HER-2/neu in bladder carcinoma". International Journal of Oncology 8.5 (1996): 957-961.
Chicago
Tommasi, S., Ditonno, P., Sisto, M., Paradiso, A., Gentile, A., Ricco, R., Schittulli, F., Jacobellis, U."HER-2/neu in bladder carcinoma". International Journal of Oncology 8, no. 5 (1996): 957-961. https://doi.org/10.3892/ijo.8.5.957
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