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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1996 Volume 8 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 1996 Volume 8 Issue 6

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Article

Differential expression of P-glycoprotein in cord blood and peripheral blood lymphocyte subpopulations

  • Authors:
    • S Aggarwal
    • A Gupta
    • T Tsuruo
    • S Gupta

  • View Affiliations / Copyright

    Affiliations: UNIV CALIF IRVINE,DIV BASIC & CLIN IMMUNOL,C 240,IRVINE,CA 92717. WESTERN MED CTR,SANTA ANA,CA.
  • Pages: 1063-1068
    |
    Published online on: June 1, 1996
       https://doi.org/10.3892/ijo.8.6.1063
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Abstract

P-glycoprotein (P-gP) is a 170 kDa glycoprotein encoded by MDR1 that appears to be involved in the secretion of a large number of molecules including hormones, cyclosporin A (CSA) and cytokines. Cord blood lymphocytes are functionally immature and are sensitive to CSA. Therefore, we compared the surface expression and function of P-gP in cord blood and peripheral blood CD4(+) and CD8(+) T cells and their naive (CD45RA(+)) and memory (CD45RO(+)) subsets. We observed that only 1% of cord blood CD4(+) and 2% CD8(+) cells expressed P-gP as compared to 7% and 10% respectively of peripheral blood from young controls. In addition, MDR1 mRNA levels were also decreased in cord blood mononuclear cells as compared to peripheral blood from young controls. The efflux function of P-gP was measured by intracellular accumulation of rhodamine 123 (Rh123, a substrate for P-gP) in the presence or absence of CSA. A higher accumulation of Rh123 was observed in cord blood CD4(+) and CD8(+) and their naive and memory cell subtype as compared to those in peripheral blood. Furthermore, cord blood CD4(+) and CD8(+) T cell subsets exhibited greater sensitivity towards CSA (% increase: 119 and 188 respectively) as compared to peripheral blood (44 and 89 respectively). A physiological role of decreased P-gP expression and function in cord blood remains to be determined.

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Copy and paste a formatted citation
Spandidos Publications style
Aggarwal S, Gupta A, Tsuruo T and Gupta S: Differential expression of P-glycoprotein in cord blood and peripheral blood lymphocyte subpopulations. Int J Oncol 8: 1063-1068, 1996.
APA
Aggarwal, S., Gupta, A., Tsuruo, T., & Gupta, S. (1996). Differential expression of P-glycoprotein in cord blood and peripheral blood lymphocyte subpopulations. International Journal of Oncology, 8, 1063-1068. https://doi.org/10.3892/ijo.8.6.1063
MLA
Aggarwal, S., Gupta, A., Tsuruo, T., Gupta, S."Differential expression of P-glycoprotein in cord blood and peripheral blood lymphocyte subpopulations". International Journal of Oncology 8.6 (1996): 1063-1068.
Chicago
Aggarwal, S., Gupta, A., Tsuruo, T., Gupta, S."Differential expression of P-glycoprotein in cord blood and peripheral blood lymphocyte subpopulations". International Journal of Oncology 8, no. 6 (1996): 1063-1068. https://doi.org/10.3892/ijo.8.6.1063
Copy and paste a formatted citation
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Spandidos Publications style
Aggarwal S, Gupta A, Tsuruo T and Gupta S: Differential expression of P-glycoprotein in cord blood and peripheral blood lymphocyte subpopulations. Int J Oncol 8: 1063-1068, 1996.
APA
Aggarwal, S., Gupta, A., Tsuruo, T., & Gupta, S. (1996). Differential expression of P-glycoprotein in cord blood and peripheral blood lymphocyte subpopulations. International Journal of Oncology, 8, 1063-1068. https://doi.org/10.3892/ijo.8.6.1063
MLA
Aggarwal, S., Gupta, A., Tsuruo, T., Gupta, S."Differential expression of P-glycoprotein in cord blood and peripheral blood lymphocyte subpopulations". International Journal of Oncology 8.6 (1996): 1063-1068.
Chicago
Aggarwal, S., Gupta, A., Tsuruo, T., Gupta, S."Differential expression of P-glycoprotein in cord blood and peripheral blood lymphocyte subpopulations". International Journal of Oncology 8, no. 6 (1996): 1063-1068. https://doi.org/10.3892/ijo.8.6.1063
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