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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 1996 Volume 8 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June 1996 Volume 8 Issue 6

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Article

Thermotolerance and sensitivity of human cancer cells to cisplatin and doxorubicin

  • Authors:
    • E Richards
    • T Begum
    • J Masters

  • View Affiliations / Copyright

    Affiliations: UCL, INST UROL, RES LABS 3RD FLOOR, LONDON W1P 7PN, ENGLAND.
  • Pages: 1265-1271
    |
    Published online on: June 1, 1996
       https://doi.org/10.3892/ijo.8.6.1265
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Abstract

Testis tumour cells are more sensitive than most other types of cancer cell to heat, radiation and chemotherapeutic drugs, both in the clinic and in vitro. Since heat shock proteins (HSP) can protect cells from the cytotoxic effects of stress, we studied their role in the sensitivity of testis tumour cells to the frequently used cancer chemotherapeutic drugs, cisplatin and doxorubicin. Clonogenic assays of 3 testis tumour cell lines (833K, GCT27, GH) and 3 bladder cancer cell lines (RT112, HT1376, MGH-U1) following a 1 h exposure to the two drugs confirmed that the testis tumour cell lines were inherently more sensitive. Having shown previously that heat shock proteins were upregulated in both cell types following a heat shock, in this study no induction of HSP was seen following treatment for 1 h with cisplatin or doxorubicin (at concentrations reducing colony forming ability by 50%) in either cell type. In contrast, chronic exposure to cisplatin (at concentrations on the threshold of cytotoxicity), but not doxorubicin, resulted in upregulation of HSP 27, but not HSP73/72, in both cell types. Testis and bladder cancer cells with heat-induced increases in HSP were thermotolerant, and this was associated with increased resistance to doxorubicin, but not cisplatin.

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Copy and paste a formatted citation
Spandidos Publications style
Richards E, Begum T and Masters J: Thermotolerance and sensitivity of human cancer cells to cisplatin and doxorubicin. Int J Oncol 8: 1265-1271, 1996.
APA
Richards, E., Begum, T., & Masters, J. (1996). Thermotolerance and sensitivity of human cancer cells to cisplatin and doxorubicin. International Journal of Oncology, 8, 1265-1271. https://doi.org/10.3892/ijo.8.6.1265
MLA
Richards, E., Begum, T., Masters, J."Thermotolerance and sensitivity of human cancer cells to cisplatin and doxorubicin". International Journal of Oncology 8.6 (1996): 1265-1271.
Chicago
Richards, E., Begum, T., Masters, J."Thermotolerance and sensitivity of human cancer cells to cisplatin and doxorubicin". International Journal of Oncology 8, no. 6 (1996): 1265-1271. https://doi.org/10.3892/ijo.8.6.1265
Copy and paste a formatted citation
x
Spandidos Publications style
Richards E, Begum T and Masters J: Thermotolerance and sensitivity of human cancer cells to cisplatin and doxorubicin. Int J Oncol 8: 1265-1271, 1996.
APA
Richards, E., Begum, T., & Masters, J. (1996). Thermotolerance and sensitivity of human cancer cells to cisplatin and doxorubicin. International Journal of Oncology, 8, 1265-1271. https://doi.org/10.3892/ijo.8.6.1265
MLA
Richards, E., Begum, T., Masters, J."Thermotolerance and sensitivity of human cancer cells to cisplatin and doxorubicin". International Journal of Oncology 8.6 (1996): 1265-1271.
Chicago
Richards, E., Begum, T., Masters, J."Thermotolerance and sensitivity of human cancer cells to cisplatin and doxorubicin". International Journal of Oncology 8, no. 6 (1996): 1265-1271. https://doi.org/10.3892/ijo.8.6.1265
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