Expression of Fas and anti-Fas-mediated apoptosis in human renal cell carcinoma

  • Authors:
    • M Inoue
    • H Yano
    • M Kojiro
  • View Affiliations

  • Published online on: July 1, 1996     https://doi.org/10.3892/ijo.9.1.49
  • Pages: 49-56
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Abstract

We investigated Fas expression and Fas-mediated apoptosis on 25 surgically resected renal cell carcinoma (RCC) tissues and 8 RCC cell lines. Immunohistochemistry demonstrated that cancer cells in the 25 tissues expressed Fas (100%). Fas expression was confirmed in all cell lines at protein and mRNA levels, but the 7 cell lines were resistant or low sensitive to anti-Fas induced apoptosis. In addition, cancer cells in all of the RCC tissues and all cell lines expressed an anti-apoptotic proto-oncogene, bcl-2 product. In conclusion, i) Fas/Fas-ligand system may be often impaired in RCCs despite their frequent expression; and ii) their frequent Bcl-2 expression may further contribute to the resistance to various apoptotic stimuli.

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July 1996
Volume 9 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Inoue M, Yano H and Kojiro M: Expression of Fas and anti-Fas-mediated apoptosis in human renal cell carcinoma. Int J Oncol 9: 49-56, 1996
APA
Inoue, M., Yano, H., & Kojiro, M. (1996). Expression of Fas and anti-Fas-mediated apoptosis in human renal cell carcinoma. International Journal of Oncology, 9, 49-56. https://doi.org/10.3892/ijo.9.1.49
MLA
Inoue, M., Yano, H., Kojiro, M."Expression of Fas and anti-Fas-mediated apoptosis in human renal cell carcinoma". International Journal of Oncology 9.1 (1996): 49-56.
Chicago
Inoue, M., Yano, H., Kojiro, M."Expression of Fas and anti-Fas-mediated apoptosis in human renal cell carcinoma". International Journal of Oncology 9, no. 1 (1996): 49-56. https://doi.org/10.3892/ijo.9.1.49