The role of human leukocyte antigen and tumor necrosis factor D as a prognostic, preventive and therapeutic factor in gastric cancer

  • Authors:
    • K Tsuji
    • K Ogoshi
    • T Shimura
    • M Hagihara
    • K Isono
    • K Kimura
    • Y Nagamachi
    • N Kashiwagi
  • View Affiliations

  • Published online on: July 1, 1996     https://doi.org/10.3892/ijo.9.1.73
  • Pages: 73-78
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Abstract

In order to clarify the immunogenetical background, host factors in oncology, human leukocyte antigen (HLA) and tumor necrosis factor (TNF) beta alleles as prognostic, preventive and therapeutic indicators were investigated in 712 patients with a histologic diagnosis of adenocarcinoma of the stomach treated with gastrectomy. HLA and TNF beta alleles were tested serologically and by DNA-PCR typing. The absence of HLA Cw1 antigen may represent resistant and prognostic factors. HLA-B51, B61 and TNF beta 10.5 kb homozygote alleles are therapeutic, survival and prognostic factors. Considering the relation with lymph node metastasis, HLA-DR4 antigen and HLA-DRB 1*0405 allele were found to be risk factors for lymph node metastasis in poorly differentiated adenocarcinoma. TNF beta 10.5 kb homozygote allele also represented a risk factor for lymph node metastasis. TNF beta 5.5 kb homozygote allele was considered a resistant factor for lymph node metastasis in poorly differentiated adenocarcinoma. HLA and TNF beta alleles can play an important role as prognostic, preventive and therapeutic indicators in gastric cancer. Therefore, TNMH (TNM with host factor) should be proposed as a new approach.

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July 1996
Volume 9 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Tsuji K, Ogoshi K, Shimura T, Hagihara M, Isono K, Kimura K, Nagamachi Y and Kashiwagi N: The role of human leukocyte antigen and tumor necrosis factor D as a prognostic, preventive and therapeutic factor in gastric cancer. Int J Oncol 9: 73-78, 1996
APA
Tsuji, K., Ogoshi, K., Shimura, T., Hagihara, M., Isono, K., Kimura, K. ... Kashiwagi, N. (1996). The role of human leukocyte antigen and tumor necrosis factor D as a prognostic, preventive and therapeutic factor in gastric cancer. International Journal of Oncology, 9, 73-78. https://doi.org/10.3892/ijo.9.1.73
MLA
Tsuji, K., Ogoshi, K., Shimura, T., Hagihara, M., Isono, K., Kimura, K., Nagamachi, Y., Kashiwagi, N."The role of human leukocyte antigen and tumor necrosis factor D as a prognostic, preventive and therapeutic factor in gastric cancer". International Journal of Oncology 9.1 (1996): 73-78.
Chicago
Tsuji, K., Ogoshi, K., Shimura, T., Hagihara, M., Isono, K., Kimura, K., Nagamachi, Y., Kashiwagi, N."The role of human leukocyte antigen and tumor necrosis factor D as a prognostic, preventive and therapeutic factor in gastric cancer". International Journal of Oncology 9, no. 1 (1996): 73-78. https://doi.org/10.3892/ijo.9.1.73