Transforming growth factor beta 1 (TGF-beta 1) expression in proliferating thyroid disease

  • Authors:
    • E Perlino
    • A Ciampolillo
    • E Maiorano
    • E Pannone
    • G Viale
    • R Giorgino
    • E Marra
  • View Affiliations

  • Published online on: July 1, 1996     https://doi.org/10.3892/ijo.9.1.83
  • Pages: 83-88
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Abstract

In order to clarify some of the molecular mechanisms involved in the pathogenesis of thyroid proliferating diseases we have investigated the role of TGF-beta in thyroid carcinoma, adenoma and multinodular goiter. TGF-beta 1 expression studies were carried out in surgically removed thyroid tissue isolated from 15 patients affected by multinodular goiter, 4 patients affected by papillary carcinoma and 4 patients affected by follicular adenoma. TGF-beta 1 gene expression, evaluated by Northern analysis, dramatically increased in malignant proliferating thyroid disease and decreased drasticly in multinodular goiter patients with respect to normal thyroid. Immunocytochemical analysis demonstrated that TGF-beta 1 is produced by an autocrine mechanism in the carcinoma and in the benign thyroid disease (multinodular goiter), whereas TGF-beta seems to be produced in adenoma tissues in both an autocrine and a paracrine fashion. This feature further supports the hypothesis that TGF-beta may contribute to regulation of thyrocyte growth and differentiation.

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July 1996
Volume 9 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Perlino E, Ciampolillo A, Maiorano E, Pannone E, Viale G, Giorgino R and Marra E: Transforming growth factor beta 1 (TGF-beta 1) expression in proliferating thyroid disease. Int J Oncol 9: 83-88, 1996
APA
Perlino, E., Ciampolillo, A., Maiorano, E., Pannone, E., Viale, G., Giorgino, R., & Marra, E. (1996). Transforming growth factor beta 1 (TGF-beta 1) expression in proliferating thyroid disease. International Journal of Oncology, 9, 83-88. https://doi.org/10.3892/ijo.9.1.83
MLA
Perlino, E., Ciampolillo, A., Maiorano, E., Pannone, E., Viale, G., Giorgino, R., Marra, E."Transforming growth factor beta 1 (TGF-beta 1) expression in proliferating thyroid disease". International Journal of Oncology 9.1 (1996): 83-88.
Chicago
Perlino, E., Ciampolillo, A., Maiorano, E., Pannone, E., Viale, G., Giorgino, R., Marra, E."Transforming growth factor beta 1 (TGF-beta 1) expression in proliferating thyroid disease". International Journal of Oncology 9, no. 1 (1996): 83-88. https://doi.org/10.3892/ijo.9.1.83