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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 1996 Volume 9 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August 1996 Volume 9 Issue 2

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Review

Genetics of colorectal cancer (Review)

  • Authors:
    • N Peddanna
    • R Mendis
    • S Holt
    • R Verma
  • View Affiliations / Copyright

    Affiliations: SUNY HLTH SCI CTR,LONG ISL COLL HOSP,DIV GENET,BROOKLYN,NY 11201. SUNY HLTH SCI CTR,LONG ISL COLL HOSP,DEPT MED,DIV GASTROENTEROL,BROOKLYN,NY 11201.
  • Pages: 327-335
    |
    Published online on: August 1, 1996
       https://doi.org/10.3892/ijo.9.2.327
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Abstract

There is an increasing awareness of the genetic basis of colon cancer and the application of gene therapy. The most commonly altered oncogenes are c-Ki-ras and c-myc, with less frequent involvement of c-src and c-erb. The loss of heterozygosity (LOH) on chromosome 5q has been frequently associated with adenomas, occurring on 17q, 18q, 1p35, 8p22 and 22q11-13 loci. This results in a loss of tumor suppressor gene for these chromosomes. The LOH on 5q was noted on the adenomatous polyposis coli (APC) and the gene on chrome-some 5 was mutated in over 55% cases of colorectal cancer, termed mutated in colon cancer (MCC). MCC is regarded as a tumor suppressor gene which is responsible for the initiation of colon cancer. The deleted in colon cancer gene (DCC) on 18q21 is a common cause of adenomas and the LOH on 17q in p53 gene are frequently seen in bowel cancer. Comparison of frequency with which tumor suppressor and oncogenes are altered in the adenomas and carcinomas suggests that there is a preferred order for their occurrence in the adenoma-carcinoma sequence. Our studies indicate that supplement with tumor suppressor oncoprotein may open a new avenue for gene therapy of colorectal cancer but steps in the identification of the gene(s) await further exploration.

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Copy and paste a formatted citation
Spandidos Publications style
Peddanna N, Mendis R, Holt S and Verma R: Genetics of colorectal cancer (Review). Int J Oncol 9: 327-335, 1996.
APA
Peddanna, N., Mendis, R., Holt, S., & Verma, R. (1996). Genetics of colorectal cancer (Review). International Journal of Oncology, 9, 327-335. https://doi.org/10.3892/ijo.9.2.327
MLA
Peddanna, N., Mendis, R., Holt, S., Verma, R."Genetics of colorectal cancer (Review)". International Journal of Oncology 9.2 (1996): 327-335.
Chicago
Peddanna, N., Mendis, R., Holt, S., Verma, R."Genetics of colorectal cancer (Review)". International Journal of Oncology 9, no. 2 (1996): 327-335. https://doi.org/10.3892/ijo.9.2.327
Copy and paste a formatted citation
x
Spandidos Publications style
Peddanna N, Mendis R, Holt S and Verma R: Genetics of colorectal cancer (Review). Int J Oncol 9: 327-335, 1996.
APA
Peddanna, N., Mendis, R., Holt, S., & Verma, R. (1996). Genetics of colorectal cancer (Review). International Journal of Oncology, 9, 327-335. https://doi.org/10.3892/ijo.9.2.327
MLA
Peddanna, N., Mendis, R., Holt, S., Verma, R."Genetics of colorectal cancer (Review)". International Journal of Oncology 9.2 (1996): 327-335.
Chicago
Peddanna, N., Mendis, R., Holt, S., Verma, R."Genetics of colorectal cancer (Review)". International Journal of Oncology 9, no. 2 (1996): 327-335. https://doi.org/10.3892/ijo.9.2.327
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