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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 1996 Volume 9 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August 1996 Volume 9 Issue 2

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Article

Prognostic value of Ki 67/MIB1 automated and quantitative immunolabelling in primary operable breast carcinomas

  • Authors:
    • C Charpin
    • S Garcia
    • C Bouvier
    • B Devictor
    • L Andra
    • M Lavaut
    • C Allasia
    • P Bonnier

  • View Affiliations / Copyright

    Affiliations: HOP NORD MARSEILLE,DEPT PATHOL,MARSEILLE,FRANCE. HOP CONCEPTION,DEPT GYNECOL ONCOL,MARSEILLE,FRANCE.
  • Pages: 337-344
    |
    Published online on: August 1, 1996
       https://doi.org/10.3892/ijo.9.2.337
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Abstract

The prognostic significance of Ki 67/MIB1 immunohistochemical assays (ICAs) was investigated in optimal technical conditions in 139 breast carcinomas. Automated ICAs (immunoperoxidase/Ventana device) was performed on frozen sections. Immunoprecipitates were quantified by computerized analysis (SAMBA) of digitized microscopic images. Mean positive surfaces (%) and quantitative immunocytochemical (QIC) index were correlated to the patients survival (8-year survival). The results showed that Ki 67/MIB1 large surfaces (cutpoint, 20%) and high QIC index (cutpoint, 12) correlated with poor overall survival (Kaplan Meier, log rank test, p=0.011 and p=0.037, BMDP software). In node positive, but not in node negative patients, large Ki 67/MIB1 surface (cutpoint, 20%) and high QIC index (cut-off 12) correlated with the overall patient survival (p=0.0037 and p=0.049). Also large Ki 67/MIB1 positive surface (cut-off, 20%) correlated with disease-free survival in all patients and node positive patients (p=0.022 and p=0.0057) but not in node negative patients. It is concluded that in optimal technical conditions (automated and quantitative immunohistochemical assays on frozen sections) Ki 67 antigen immunohistochemical expression in breast carcinomas tissue has a prognostic significance in node positive patients but not in node negative patients.

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Copy and paste a formatted citation
Spandidos Publications style
Charpin C, Garcia S, Bouvier C, Devictor B, Andra L, Lavaut M, Allasia C and Bonnier P: Prognostic value of Ki 67/MIB1 automated and quantitative immunolabelling in primary operable breast carcinomas. Int J Oncol 9: 337-344, 1996.
APA
Charpin, C., Garcia, S., Bouvier, C., Devictor, B., Andra, L., Lavaut, M. ... Bonnier, P. (1996). Prognostic value of Ki 67/MIB1 automated and quantitative immunolabelling in primary operable breast carcinomas. International Journal of Oncology, 9, 337-344. https://doi.org/10.3892/ijo.9.2.337
MLA
Charpin, C., Garcia, S., Bouvier, C., Devictor, B., Andra, L., Lavaut, M., Allasia, C., Bonnier, P."Prognostic value of Ki 67/MIB1 automated and quantitative immunolabelling in primary operable breast carcinomas". International Journal of Oncology 9.2 (1996): 337-344.
Chicago
Charpin, C., Garcia, S., Bouvier, C., Devictor, B., Andra, L., Lavaut, M., Allasia, C., Bonnier, P."Prognostic value of Ki 67/MIB1 automated and quantitative immunolabelling in primary operable breast carcinomas". International Journal of Oncology 9, no. 2 (1996): 337-344. https://doi.org/10.3892/ijo.9.2.337
Copy and paste a formatted citation
x
Spandidos Publications style
Charpin C, Garcia S, Bouvier C, Devictor B, Andra L, Lavaut M, Allasia C and Bonnier P: Prognostic value of Ki 67/MIB1 automated and quantitative immunolabelling in primary operable breast carcinomas. Int J Oncol 9: 337-344, 1996.
APA
Charpin, C., Garcia, S., Bouvier, C., Devictor, B., Andra, L., Lavaut, M. ... Bonnier, P. (1996). Prognostic value of Ki 67/MIB1 automated and quantitative immunolabelling in primary operable breast carcinomas. International Journal of Oncology, 9, 337-344. https://doi.org/10.3892/ijo.9.2.337
MLA
Charpin, C., Garcia, S., Bouvier, C., Devictor, B., Andra, L., Lavaut, M., Allasia, C., Bonnier, P."Prognostic value of Ki 67/MIB1 automated and quantitative immunolabelling in primary operable breast carcinomas". International Journal of Oncology 9.2 (1996): 337-344.
Chicago
Charpin, C., Garcia, S., Bouvier, C., Devictor, B., Andra, L., Lavaut, M., Allasia, C., Bonnier, P."Prognostic value of Ki 67/MIB1 automated and quantitative immunolabelling in primary operable breast carcinomas". International Journal of Oncology 9, no. 2 (1996): 337-344. https://doi.org/10.3892/ijo.9.2.337
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