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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1996 Volume 9 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1996 Volume 9 Issue 3

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Article

p53 and cyclin D1 protein expression in glottic laryngeal squamous cell carcinomas involving the anterior commissure (pT1bN0M0)

  • Authors:
    • L Pignataro
    • P Capaccio
    • G Pruneri
    • N Carboni
    • N Fracchiolla
    • R Richelda
    • G Scaramellini
    • A Neri
    • R Buffa

  • View Affiliations / Copyright

    Affiliations: UNIV MILAN,OSPED MAGGIORE,IRCCS,SERV ANAT PATOL 2,I-20122 MILAN,ITALY. UNIV MILAN,OSPED MAGGIORE,IRCCS,IST SCI MED,SERV EMATOL,LAB EMATOL SPERIMENTALE & GENET MOL,I-20122 MILAN,ITALY.
  • Pages: 553-557
    |
    Published online on: September 1, 1996
       https://doi.org/10.3892/ijo.9.3.553
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Abstract

The prognosis of patients carrying glottic squamous cell carcinomas (GSCCs) involving the anterior commissure is often unpredictable. In order to assess the possible prognostic role of new and reliable parameters, p53 and cyclin D1 protein expression was immunohistochemically analysed in pathological samples from 27 patients with GSCG (pTlbNOMO) and a median follow-up of 90 months. p53 protein expression was observed in the majority of patients (15/27), but it did not correlate with their clinical outcome; p53 protein immunoreactivity was frequently observed in normal (9/14), mildy dysplastic (10/14) and highly dysplastic (3/7) mucosa samples, suggesting that its overexpression may be involved in the earliest phases of the multistep tumourigenesis of laryngeal squamous cell carcinomas (LSCCs); neither the non-neoplastic nor the neoplastic samples expressed any cyclin D1. As cyclin D1 protein expression has been associated with a high frequency of nodal metastases, its absence in our series could ba related to the rarity of nodal involvement in early glottic LSCCs.

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Copy and paste a formatted citation
Spandidos Publications style
Pignataro L, Capaccio P, Pruneri G, Carboni N, Fracchiolla N, Richelda R, Scaramellini G, Neri A and Buffa R: p53 and cyclin D1 protein expression in glottic laryngeal squamous cell carcinomas involving the anterior commissure (pT1bN0M0). Int J Oncol 9: 553-557, 1996.
APA
Pignataro, L., Capaccio, P., Pruneri, G., Carboni, N., Fracchiolla, N., Richelda, R. ... Buffa, R. (1996). p53 and cyclin D1 protein expression in glottic laryngeal squamous cell carcinomas involving the anterior commissure (pT1bN0M0). International Journal of Oncology, 9, 553-557. https://doi.org/10.3892/ijo.9.3.553
MLA
Pignataro, L., Capaccio, P., Pruneri, G., Carboni, N., Fracchiolla, N., Richelda, R., Scaramellini, G., Neri, A., Buffa, R."p53 and cyclin D1 protein expression in glottic laryngeal squamous cell carcinomas involving the anterior commissure (pT1bN0M0)". International Journal of Oncology 9.3 (1996): 553-557.
Chicago
Pignataro, L., Capaccio, P., Pruneri, G., Carboni, N., Fracchiolla, N., Richelda, R., Scaramellini, G., Neri, A., Buffa, R."p53 and cyclin D1 protein expression in glottic laryngeal squamous cell carcinomas involving the anterior commissure (pT1bN0M0)". International Journal of Oncology 9, no. 3 (1996): 553-557. https://doi.org/10.3892/ijo.9.3.553
Copy and paste a formatted citation
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Spandidos Publications style
Pignataro L, Capaccio P, Pruneri G, Carboni N, Fracchiolla N, Richelda R, Scaramellini G, Neri A and Buffa R: p53 and cyclin D1 protein expression in glottic laryngeal squamous cell carcinomas involving the anterior commissure (pT1bN0M0). Int J Oncol 9: 553-557, 1996.
APA
Pignataro, L., Capaccio, P., Pruneri, G., Carboni, N., Fracchiolla, N., Richelda, R. ... Buffa, R. (1996). p53 and cyclin D1 protein expression in glottic laryngeal squamous cell carcinomas involving the anterior commissure (pT1bN0M0). International Journal of Oncology, 9, 553-557. https://doi.org/10.3892/ijo.9.3.553
MLA
Pignataro, L., Capaccio, P., Pruneri, G., Carboni, N., Fracchiolla, N., Richelda, R., Scaramellini, G., Neri, A., Buffa, R."p53 and cyclin D1 protein expression in glottic laryngeal squamous cell carcinomas involving the anterior commissure (pT1bN0M0)". International Journal of Oncology 9.3 (1996): 553-557.
Chicago
Pignataro, L., Capaccio, P., Pruneri, G., Carboni, N., Fracchiolla, N., Richelda, R., Scaramellini, G., Neri, A., Buffa, R."p53 and cyclin D1 protein expression in glottic laryngeal squamous cell carcinomas involving the anterior commissure (pT1bN0M0)". International Journal of Oncology 9, no. 3 (1996): 553-557. https://doi.org/10.3892/ijo.9.3.553
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