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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2008 Volume 33 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2008 Volume 33 Issue 2

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Article

Cell motility affects the intensity of gap junctional coupling in prostate carcinoma and melanoma cell populations

  • Authors:
    • Anna Daniel-Wójcik
    • Katarzyna Misztal
    • Iga Bechyne
    • Jolanta Sroka
    • Katarzyna Miekus
    • Zbigniew Madeja
    • Jaroslaw Czyz

  • View Affiliations / Copyright

    Affiliations: Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland
  • Pages: 309-315
    |
    Published online on: August 1, 2008
       https://doi.org/10.3892/ijo_00000010
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Abstract

Connexins and gap junctions play a crucial role during carcinogenesis. While diverse regulatory systems have been shown to modulate their function, the influence of cell motility on the intensity of gap junctional intercellular coupling has yet to be systematically addressed. Since cancer cell motility and intercellular coupling determine cancer development, we aimed at elucidating how mutual cell translocation modulates the intensity of gap junctional coupling in cell populations. Time-lapse analyses of the motility of connexin43 (Cx43)-coupled rat prostate carcinoma (MAT-LyLu) and mouse melanoma (B16) cells cultured on hyper-adhesive substrata revealed a reduced intensity of intercellular translocations in the two cell populations compared to the control conditions. While no detectable effects on the architecture of the actin cytoskeleton and Cx43 expression and phosphorylation were observed, the inhibition of cell motility was paralleled by an increase in the abundance of Cx43-positive plaques in cell-to-cell contacts and an enhancement of gap junctional coupling in cell populations cultured on hyper-adhesive substrata. Thus, a direct correlation between two cellular parameters crucial for carcinogenesis, i.e. cell motility and gap junctional coupling intensity exists in cancer cell populations.

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Copy and paste a formatted citation
Spandidos Publications style
Daniel-Wójcik A, Misztal K, Bechyne I, Sroka J, Miekus K, Madeja Z and Czyz J: Cell motility affects the intensity of gap junctional coupling in prostate carcinoma and melanoma cell populations. Int J Oncol 33: 309-315, 2008.
APA
Daniel-Wójcik, A., Misztal, K., Bechyne, I., Sroka, J., Miekus, K., Madeja, Z., & Czyz, J. (2008). Cell motility affects the intensity of gap junctional coupling in prostate carcinoma and melanoma cell populations. International Journal of Oncology, 33, 309-315. https://doi.org/10.3892/ijo_00000010
MLA
Daniel-Wójcik, A., Misztal, K., Bechyne, I., Sroka, J., Miekus, K., Madeja, Z., Czyz, J."Cell motility affects the intensity of gap junctional coupling in prostate carcinoma and melanoma cell populations". International Journal of Oncology 33.2 (2008): 309-315.
Chicago
Daniel-Wójcik, A., Misztal, K., Bechyne, I., Sroka, J., Miekus, K., Madeja, Z., Czyz, J."Cell motility affects the intensity of gap junctional coupling in prostate carcinoma and melanoma cell populations". International Journal of Oncology 33, no. 2 (2008): 309-315. https://doi.org/10.3892/ijo_00000010
Copy and paste a formatted citation
x
Spandidos Publications style
Daniel-Wójcik A, Misztal K, Bechyne I, Sroka J, Miekus K, Madeja Z and Czyz J: Cell motility affects the intensity of gap junctional coupling in prostate carcinoma and melanoma cell populations. Int J Oncol 33: 309-315, 2008.
APA
Daniel-Wójcik, A., Misztal, K., Bechyne, I., Sroka, J., Miekus, K., Madeja, Z., & Czyz, J. (2008). Cell motility affects the intensity of gap junctional coupling in prostate carcinoma and melanoma cell populations. International Journal of Oncology, 33, 309-315. https://doi.org/10.3892/ijo_00000010
MLA
Daniel-Wójcik, A., Misztal, K., Bechyne, I., Sroka, J., Miekus, K., Madeja, Z., Czyz, J."Cell motility affects the intensity of gap junctional coupling in prostate carcinoma and melanoma cell populations". International Journal of Oncology 33.2 (2008): 309-315.
Chicago
Daniel-Wójcik, A., Misztal, K., Bechyne, I., Sroka, J., Miekus, K., Madeja, Z., Czyz, J."Cell motility affects the intensity of gap junctional coupling in prostate carcinoma and melanoma cell populations". International Journal of Oncology 33, no. 2 (2008): 309-315. https://doi.org/10.3892/ijo_00000010
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