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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2008 Volume 33 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2008 Volume 33 Issue 2

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Article

Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor

  • Authors:
    • Ian S. Zagon
    • Shawn Kreiner
    • Jeffery J. Heslop
    • Andrea B. Conway
    • Clinton R. Morgan
    • Patricia J. McLaughlin

  • View Affiliations / Copyright

    Affiliations: Department of Neural and Behavioral Sciences, H109, The M.S. Hershey Medical Center, Hershey, PA 17033, USA. isz1@psu.edu
  • Pages: 317-323
    |
    Published online on: August 1, 2008
       https://doi.org/10.3892/ijo_00000011
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Abstract

This study examined overexpression of the opioid growth factor receptor (OGFr) in pancreatic cancer cells and phenotypic changes in tumorigenicity. Tumors of MIA PaCa-2 cells transfected with OGFr cDNA (OGFr-1) had 3.3 times more OGFr than empty vector (EV) neoplasias, and 4.3 times more OGFr than tumors from wild-type (WT) mice. No differences in OGFr binding were detected between tumors of EV and WT animals. Tumor incidence in OGFr-1 animals was reduced by up to 50% from EV mice. Latency times for OGFr-1 tumor expression were increased 30%, tumor volume was decreased 70%, and DNA synthesis was reduced 24% relative to EV mice. Exogenous OGF reduced OGFr-1 tumor volume up to 55% compared to OGFr-1 mice given vehicle. These data support OGFr gene function as a regulator of cell proliferation that impacts on tumorigenic expression, and suggest that molecular and pharmacological manipulation of OGFr may prevent or delay human pancreatic cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Zagon IS, Kreiner S, Heslop JJ, Conway AB, Morgan CR and McLaughlin PJ: Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor. Int J Oncol 33: 317-323, 2008.
APA
Zagon, I.S., Kreiner, S., Heslop, J.J., Conway, A.B., Morgan, C.R., & McLaughlin, P.J. (2008). Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor. International Journal of Oncology, 33, 317-323. https://doi.org/10.3892/ijo_00000011
MLA
Zagon, I. S., Kreiner, S., Heslop, J. J., Conway, A. B., Morgan, C. R., McLaughlin, P. J."Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor". International Journal of Oncology 33.2 (2008): 317-323.
Chicago
Zagon, I. S., Kreiner, S., Heslop, J. J., Conway, A. B., Morgan, C. R., McLaughlin, P. J."Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor". International Journal of Oncology 33, no. 2 (2008): 317-323. https://doi.org/10.3892/ijo_00000011
Copy and paste a formatted citation
x
Spandidos Publications style
Zagon IS, Kreiner S, Heslop JJ, Conway AB, Morgan CR and McLaughlin PJ: Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor. Int J Oncol 33: 317-323, 2008.
APA
Zagon, I.S., Kreiner, S., Heslop, J.J., Conway, A.B., Morgan, C.R., & McLaughlin, P.J. (2008). Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor. International Journal of Oncology, 33, 317-323. https://doi.org/10.3892/ijo_00000011
MLA
Zagon, I. S., Kreiner, S., Heslop, J. J., Conway, A. B., Morgan, C. R., McLaughlin, P. J."Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor". International Journal of Oncology 33.2 (2008): 317-323.
Chicago
Zagon, I. S., Kreiner, S., Heslop, J. J., Conway, A. B., Morgan, C. R., McLaughlin, P. J."Prevention and delay in progression of human pancreatic cancer by stable overexpression of the opioid growth factor receptor". International Journal of Oncology 33, no. 2 (2008): 317-323. https://doi.org/10.3892/ijo_00000011
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