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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2008 Volume 33 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2008 Volume 33 Issue 2

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Article

The role of oxidative stress in apoptosis induced by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in human colon adenocarcinoma HT-29 cells

  • Authors:
    • Patrizia Portanova
    • Tiziana Russo
    • Ornella Pellerito
    • Giuseppe Calvaruso
    • Michela Giuliano
    • Renza Vento
    • Giovanni Tesoriere

  • View Affiliations / Copyright

    Affiliations: Dipartimento di Scienze Biochimiche, Università degli Studi di Palermo, 90127 Palermo, Italy
  • Pages: 325-331
    |
    Published online on: August 1, 2008
       https://doi.org/10.3892/ijo_00000012
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Abstract

Histone deacetylase inhibitors (HDACIs) activate genes that promote cell cycle arrest and apoptosis in a number of tumor cells. This study showed that suberoylanilide hydroxamic acid (SAHA), a potent and commonly used HDACI, induced apoptosis in human colon adenocarcinoma HT-29 cells in a time- and dose-dependent manner. This effect was accompanied by the induction of oxidative stress, dissipation of mitochondrial transmembrane potential and activation of executioner caspases. Moreover, SAHA increased the levels of phosphorylated active forms of p38 and JNK. The addition of either the antioxidant N-acetylcysteine or the specific inhibitor of NADPH oxidase diphenylene iodonium chloride reduced the cytotoxic effects of SAHA in HT-29 cells, suggesting that the induction of oxidative stress represents a crucial event in the apoptotic mechanism. In addition, SAHA up-regulated the death receptor DR5, inducing the activation of caspase-8 with the consequent cleavage of Bid. Furthermore, SAHA down-regulated FLIPL and Akt, two proteins which exert an inhibitory role in apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Portanova P, Russo T, Pellerito O, Calvaruso G, Giuliano M, Vento R and Tesoriere G: The role of oxidative stress in apoptosis induced by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in human colon adenocarcinoma HT-29 cells. Int J Oncol 33: 325-331, 2008.
APA
Portanova, P., Russo, T., Pellerito, O., Calvaruso, G., Giuliano, M., Vento, R., & Tesoriere, G. (2008). The role of oxidative stress in apoptosis induced by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in human colon adenocarcinoma HT-29 cells. International Journal of Oncology, 33, 325-331. https://doi.org/10.3892/ijo_00000012
MLA
Portanova, P., Russo, T., Pellerito, O., Calvaruso, G., Giuliano, M., Vento, R., Tesoriere, G."The role of oxidative stress in apoptosis induced by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in human colon adenocarcinoma HT-29 cells". International Journal of Oncology 33.2 (2008): 325-331.
Chicago
Portanova, P., Russo, T., Pellerito, O., Calvaruso, G., Giuliano, M., Vento, R., Tesoriere, G."The role of oxidative stress in apoptosis induced by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in human colon adenocarcinoma HT-29 cells". International Journal of Oncology 33, no. 2 (2008): 325-331. https://doi.org/10.3892/ijo_00000012
Copy and paste a formatted citation
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Spandidos Publications style
Portanova P, Russo T, Pellerito O, Calvaruso G, Giuliano M, Vento R and Tesoriere G: The role of oxidative stress in apoptosis induced by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in human colon adenocarcinoma HT-29 cells. Int J Oncol 33: 325-331, 2008.
APA
Portanova, P., Russo, T., Pellerito, O., Calvaruso, G., Giuliano, M., Vento, R., & Tesoriere, G. (2008). The role of oxidative stress in apoptosis induced by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in human colon adenocarcinoma HT-29 cells. International Journal of Oncology, 33, 325-331. https://doi.org/10.3892/ijo_00000012
MLA
Portanova, P., Russo, T., Pellerito, O., Calvaruso, G., Giuliano, M., Vento, R., Tesoriere, G."The role of oxidative stress in apoptosis induced by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in human colon adenocarcinoma HT-29 cells". International Journal of Oncology 33.2 (2008): 325-331.
Chicago
Portanova, P., Russo, T., Pellerito, O., Calvaruso, G., Giuliano, M., Vento, R., Tesoriere, G."The role of oxidative stress in apoptosis induced by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in human colon adenocarcinoma HT-29 cells". International Journal of Oncology 33, no. 2 (2008): 325-331. https://doi.org/10.3892/ijo_00000012
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