Aberrant expression of B203.13 antigen in acute lymphoid leukemia of B-cell origin

  • Authors:
    • Giuliana Gobbi
    • Prisco Mirandola
    • Chiara Malinverno
    • Ivonne Sponzilli
    • Cecilia Carubbi
    • Francesca Ricci
    • Roberto Binazzi
    • Giuseppe Basso
    • Gabriella Giuliani-Piccari
    • Giulia Ramazzotti
    • Guido Pasquantonio
    • Lucio Cocco
    • Marco Vitale
  • View Affiliations

  • Published online on: August 1, 2008     https://doi.org/10.3892/ijo_00000017
  • Pages: 371-374
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Abstract

The B203.13 monoclonal antibody was developed by immunizing mice with the B/monocyte biphenotypic cell line B1b. During normal hematopoiesis B203.13 is expressed on a fraction of CD34+ cells, while on mature cells it is only present on B-lymphocytes. We tested this antibody as a marker of childhood B-acute lymphoblastic leukemia (B-ALL). Bone marrow aspirates from 139 cases of early B-ALL and 25 controls were studied. About 40% of the B-ALL patients expressed B203.13. In these patients, B203.13 was constantly co-expressed with CD10, but never co-expressed with CD20, contrary to the controls. The CD10+/B203.13+ phenotype was specific to B-ALL, since CD10+/CD20+ cells from common acute lymphoblastic leukemia (c-ALL) did not express B203.13. We concluded that the use of B203.13 in association with CD10 and CD20 provides meaningful information for distinguishing normal residual B-cells from leukemic B-lymphoblasts and that recurrence of a CD10+/B203.13+ phenotype after transplantation may be a very early relapse indicator of early B-acute lymphoblastic leukemia.

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August 2008
Volume 33 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Gobbi G, Mirandola P, Malinverno C, Sponzilli I, Carubbi C, Ricci F, Binazzi R, Basso G, Giuliani-Piccari G, Ramazzotti G, Ramazzotti G, et al: Aberrant expression of B203.13 antigen in acute lymphoid leukemia of B-cell origin. Int J Oncol 33: 371-374, 2008.
APA
Gobbi, G., Mirandola, P., Malinverno, C., Sponzilli, I., Carubbi, C., Ricci, F. ... Vitale, M. (2008). Aberrant expression of B203.13 antigen in acute lymphoid leukemia of B-cell origin. International Journal of Oncology, 33, 371-374. https://doi.org/10.3892/ijo_00000017
MLA
Gobbi, G., Mirandola, P., Malinverno, C., Sponzilli, I., Carubbi, C., Ricci, F., Binazzi, R., Basso, G., Giuliani-Piccari, G., Ramazzotti, G., Pasquantonio, G., Cocco, L., Vitale, M."Aberrant expression of B203.13 antigen in acute lymphoid leukemia of B-cell origin". International Journal of Oncology 33.2 (2008): 371-374.
Chicago
Gobbi, G., Mirandola, P., Malinverno, C., Sponzilli, I., Carubbi, C., Ricci, F., Binazzi, R., Basso, G., Giuliani-Piccari, G., Ramazzotti, G., Pasquantonio, G., Cocco, L., Vitale, M."Aberrant expression of B203.13 antigen in acute lymphoid leukemia of B-cell origin". International Journal of Oncology 33, no. 2 (2008): 371-374. https://doi.org/10.3892/ijo_00000017