Clinical implication of glucose transport and metabolism evaluated by 18F-FDG PET in hepatocellular carcinoma

  • Authors:
    • Bishnuhari Paudyal
    • Pramila Paudyal
    • Noboru Oriuchi
    • Yoshito Tsushima
    • Takashi Nakajima
    • Keigo Endo
  • View Affiliations

  • Published online on: November 1, 2008     https://doi.org/10.3892/ijo_00000093
  • Pages: 1047-1054
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Abstract

Hepatocellular carcinoma (HCC) has variable 18F-fluoro-2-deoxy-D-glucose (18F-FDG) uptake and the relationship between 18F-FDG uptake with the expression of glucose transporters (Gluts) and hexokinase II (HK-II) has not been extensively examined. Present study explored the role of 18F-FDG positron emission tomography (PET) as a clinical significance and the association with Gluts and HK-II in patients with HCC. Whole body 18F-FDG PET, immunohistochemistry and western blot analysis of Glut-1 to Glut-5 and HK-II were performed in 31 patients (24 male and 7 female, range 48-75 years) with HCC. Significant correlation was found between 18F-FDG uptake and overall expression of Glut-2 (ρ=0.55, p=0.002) and HK-II (ρ=0.37, p=0.04). Expression of HK-II was correlated with Glut-2 (ρ=0.57, p=0.0009) but not with other Gluts, which indicated that Glut-2 is a major glucose transporter. The prognosis of patients with SUV ≥2 and positive Glut-2 were significantly worse than that with SUV <2 and negative Glut-2 (p=0.005 and p=0.03), respectively. Multivariate analysis showed that SUV and lymph node metastasis were independent prognostic factors. The present study indicated that combined evaluation of 18F-FDG uptake and expression of Glut-2 might have an important role for management of patients with HCC.

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November 2008
Volume 33 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Paudyal B, Paudyal P, Oriuchi N, Tsushima Y, Nakajima T and Endo K: Clinical implication of glucose transport and metabolism evaluated by 18F-FDG PET in hepatocellular carcinoma. Int J Oncol 33: 1047-1054, 2008.
APA
Paudyal, B., Paudyal, P., Oriuchi, N., Tsushima, Y., Nakajima, T., & Endo, K. (2008). Clinical implication of glucose transport and metabolism evaluated by 18F-FDG PET in hepatocellular carcinoma. International Journal of Oncology, 33, 1047-1054. https://doi.org/10.3892/ijo_00000093
MLA
Paudyal, B., Paudyal, P., Oriuchi, N., Tsushima, Y., Nakajima, T., Endo, K."Clinical implication of glucose transport and metabolism evaluated by 18F-FDG PET in hepatocellular carcinoma". International Journal of Oncology 33.5 (2008): 1047-1054.
Chicago
Paudyal, B., Paudyal, P., Oriuchi, N., Tsushima, Y., Nakajima, T., Endo, K."Clinical implication of glucose transport and metabolism evaluated by 18F-FDG PET in hepatocellular carcinoma". International Journal of Oncology 33, no. 5 (2008): 1047-1054. https://doi.org/10.3892/ijo_00000093