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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2008 Volume 33 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2008 Volume 33 Issue 5

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Article

L-glutamine Schiff base copper complex as a proteasome inhibitor and an apoptosis inducer in human cancer cells

  • Authors:
    • Yan Xiao
    • Caifeng Bi
    • Yuhua Fan
    • Cindy Cui
    • Xia Zhang
    • Q. Ping Dou

  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao, P.R. China
  • Pages: 1073-1079
    |
    Published online on: November 1, 2008
       https://doi.org/10.3892/ijo_00000096
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Abstract

Interest in the use of metallic compounds for cancer treatment has been increasing since the discovery of cisplatin. Clinical studies suggest the use of proteasome inhibitors as potential novel anticancer agents. L-glutamine is the most abundant free amino acid in the body, and has been shown to play a regulatory role in several cellular processes, including metabolism, degradation, redox potential and cellular integrity. Although glutamine is reported to play a role in the regulation of apoptosis, the effect of glutamine copper complex on tumor cells and the involved molecular mechanism have not been investigated. Here, for the first time, we report that a newly synthesized L-glutamine-containing copper complex has proteasome-inhibitory activity in human breast cancer and leukemia cells. The inhibition of the tumor proteasomal activity results in the accumulation of ubiquitinated proteins and ubiquitinated form of IκB-α, a natural proteasome substrate, followed by induction of apoptosis. Furthermore, this glutamine Schiff base copper complex selectively inhibits the proteasomal activity and induces cell death in cultured breast cancer cells, but not normal, immortalized breast cells. Our data suggest that glutamine Schiff base copper complexes have a potential use for to be used in cancer treatment and prevention.

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Copy and paste a formatted citation
Spandidos Publications style
Xiao Y, Bi C, Fan Y, Cui C, Zhang X and Dou QP: L-glutamine Schiff base copper complex as a proteasome inhibitor and an apoptosis inducer in human cancer cells. Int J Oncol 33: 1073-1079, 2008.
APA
Xiao, Y., Bi, C., Fan, Y., Cui, C., Zhang, X., & Dou, Q.P. (2008). L-glutamine Schiff base copper complex as a proteasome inhibitor and an apoptosis inducer in human cancer cells. International Journal of Oncology, 33, 1073-1079. https://doi.org/10.3892/ijo_00000096
MLA
Xiao, Y., Bi, C., Fan, Y., Cui, C., Zhang, X., Dou, Q. P."L-glutamine Schiff base copper complex as a proteasome inhibitor and an apoptosis inducer in human cancer cells". International Journal of Oncology 33.5 (2008): 1073-1079.
Chicago
Xiao, Y., Bi, C., Fan, Y., Cui, C., Zhang, X., Dou, Q. P."L-glutamine Schiff base copper complex as a proteasome inhibitor and an apoptosis inducer in human cancer cells". International Journal of Oncology 33, no. 5 (2008): 1073-1079. https://doi.org/10.3892/ijo_00000096
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao Y, Bi C, Fan Y, Cui C, Zhang X and Dou QP: L-glutamine Schiff base copper complex as a proteasome inhibitor and an apoptosis inducer in human cancer cells. Int J Oncol 33: 1073-1079, 2008.
APA
Xiao, Y., Bi, C., Fan, Y., Cui, C., Zhang, X., & Dou, Q.P. (2008). L-glutamine Schiff base copper complex as a proteasome inhibitor and an apoptosis inducer in human cancer cells. International Journal of Oncology, 33, 1073-1079. https://doi.org/10.3892/ijo_00000096
MLA
Xiao, Y., Bi, C., Fan, Y., Cui, C., Zhang, X., Dou, Q. P."L-glutamine Schiff base copper complex as a proteasome inhibitor and an apoptosis inducer in human cancer cells". International Journal of Oncology 33.5 (2008): 1073-1079.
Chicago
Xiao, Y., Bi, C., Fan, Y., Cui, C., Zhang, X., Dou, Q. P."L-glutamine Schiff base copper complex as a proteasome inhibitor and an apoptosis inducer in human cancer cells". International Journal of Oncology 33, no. 5 (2008): 1073-1079. https://doi.org/10.3892/ijo_00000096
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