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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2008 Volume 33 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2008 Volume 33 Issue 6

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Article

Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2

  • Authors:
    • Jean-Luc Brun
    • Annie Cortez
    • Frédéric Commo
    • Serge Uzan
    • Roman Rouzier
    • Emile Daraï

  • View Affiliations / Copyright

    Affiliations: Service de Gynécologie-Obstétrique, Hôpital Tenon, 75020 Paris, France. jean-luc.brun@tnn.aphp.fr
  • Pages: 1239-1246
    |
    Published online on: December 1, 2008
       https://doi.org/10.3892/ijo_00000114
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Abstract

Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play key roles in tumorigenesis, but little is known of their expression according to mucinous or serous type. This study aimed to evaluate the immunohistochemical expression of MMP-2, -7, -9, MT1-MMP, TIMP-1 and -2 in these tumors. A tissue microarray was set up including 99 serous (25 benign, 27 borderline, 47 malignant) and 79 mucinous (25 benign, 44 borderline, 10 malignant) ovarian tumors. Immunostaining results were scored by using the HSCORE and assessed by univariate, unsupervised hierarchical clustering and multidimensional scaling analyses. Epithelial expression of MMP-2, -7, -9, MT1-MMP, TIMP-2, but not TIMP-1, was higher in serous than mucinous tumors. Stromal expression of MMP-7 was higher in serous tumors. Alterations in MT1-MMP, MMP-7 and -9 were found in malignant serous tumors, while benign and borderline tumors shared similar expressions. By unsupervised hierarchical clustering analysis, mucinous and serous tumors were better differentiated by epithelial than stromal MMP and TIMP immunolabelling. By multidimensional scaling analysis, the expressions of MMPs and TIMPs were scattered in serous tumors and homogeneous for mucinous tumors. In conclusion, our results support the differential expression in MMPs and TIMPs of ovarian tumors according to serous or mucinous histology.

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Copy and paste a formatted citation
Spandidos Publications style
Brun J, Cortez A, Commo F, Uzan S, Rouzier R and Daraï E: Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2. Int J Oncol 33: 1239-1246, 2008.
APA
Brun, J., Cortez, A., Commo, F., Uzan, S., Rouzier, R., & Daraï, E. (2008). Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2. International Journal of Oncology, 33, 1239-1246. https://doi.org/10.3892/ijo_00000114
MLA
Brun, J., Cortez, A., Commo, F., Uzan, S., Rouzier, R., Daraï, E."Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2". International Journal of Oncology 33.6 (2008): 1239-1246.
Chicago
Brun, J., Cortez, A., Commo, F., Uzan, S., Rouzier, R., Daraï, E."Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2". International Journal of Oncology 33, no. 6 (2008): 1239-1246. https://doi.org/10.3892/ijo_00000114
Copy and paste a formatted citation
x
Spandidos Publications style
Brun J, Cortez A, Commo F, Uzan S, Rouzier R and Daraï E: Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2. Int J Oncol 33: 1239-1246, 2008.
APA
Brun, J., Cortez, A., Commo, F., Uzan, S., Rouzier, R., & Daraï, E. (2008). Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2. International Journal of Oncology, 33, 1239-1246. https://doi.org/10.3892/ijo_00000114
MLA
Brun, J., Cortez, A., Commo, F., Uzan, S., Rouzier, R., Daraï, E."Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2". International Journal of Oncology 33.6 (2008): 1239-1246.
Chicago
Brun, J., Cortez, A., Commo, F., Uzan, S., Rouzier, R., Daraï, E."Serous and mucinous ovarian tumors express different profiles of MMP-2, -7, -9, MT1-MMP, and TIMP-1 and -2". International Journal of Oncology 33, no. 6 (2008): 1239-1246. https://doi.org/10.3892/ijo_00000114
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