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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2009 Volume 34 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2009 Volume 34 Issue 6

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Review

Role of V-ATPases in solid tumors: Importance of the subunit C (Review)

  • Authors:
    • Mario Pérez-Sayáns
    • Abel García-García
    • María Dolores Reboiras-López
    • Pilar Gándara-Vila

  • View Affiliations / Copyright

    Affiliations: Facultad de Odontología, Entrerríos s/n, Santiago de Compostela, C.P. 15782, Spain. perezsayans@gmail.com
  • Pages: 1513-1520
    |
    Published online on: June 1, 2009
       https://doi.org/10.3892/ijo_00000280
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Abstract

Acidity is one of the main characteristics of OSCC (oral squamous cell carcinoma) as a solid tumor. The V-ATPase is the primary regulator of the tumor microenvironment, by means of proton extrusion to the extracellular medium. The decrease in extracellular pH confers the cells a resistant, highly invasive and metastatic phenotype. However, the acid medium confers an optimum pH to the degradative enzymes (such as proteases and MMPs) for their proper functioning. The C subunit (ATP6V1C) of V1 intra-membrane domain of the V-ATPase, is primarily responsible for its enzymatic function, through the control of a reversible dissociation of V0 and V1 domains. In this review, we describe the importance of V-ATPases in the control of tumor microenvironment, the potential strategies as protein targeting to improve the effectiveness of drug treatment and the role of the C subunit as the primarily responsible of the enzymatic control. The inhibition of the V-ATPase activity through PPIs (proton inhibitors) seems to reduce the destructive and metastatic capacity in tumors, such as hepatocellular carcinoma. Nevertheless, none of these inhibitors was proven to be useful in OSCC; therefore, it is highly important to carry out further studies in order to develop specific inhibitors of the C subunit, to control the devastating effects of OSCC.

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Copy and paste a formatted citation
Spandidos Publications style
Pérez-Sayáns M, García-García A, Reboiras-López MD and Gándara-Vila P: Role of V-ATPases in solid tumors: Importance of the subunit C (Review). Int J Oncol 34: 1513-1520, 2009.
APA
Pérez-Sayáns, M., García-García, A., Reboiras-López, M.D., & Gándara-Vila, P. (2009). Role of V-ATPases in solid tumors: Importance of the subunit C (Review). International Journal of Oncology, 34, 1513-1520. https://doi.org/10.3892/ijo_00000280
MLA
Pérez-Sayáns, M., García-García, A., Reboiras-López, M. D., Gándara-Vila, P."Role of V-ATPases in solid tumors: Importance of the subunit C (Review)". International Journal of Oncology 34.6 (2009): 1513-1520.
Chicago
Pérez-Sayáns, M., García-García, A., Reboiras-López, M. D., Gándara-Vila, P."Role of V-ATPases in solid tumors: Importance of the subunit C (Review)". International Journal of Oncology 34, no. 6 (2009): 1513-1520. https://doi.org/10.3892/ijo_00000280
Copy and paste a formatted citation
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Spandidos Publications style
Pérez-Sayáns M, García-García A, Reboiras-López MD and Gándara-Vila P: Role of V-ATPases in solid tumors: Importance of the subunit C (Review). Int J Oncol 34: 1513-1520, 2009.
APA
Pérez-Sayáns, M., García-García, A., Reboiras-López, M.D., & Gándara-Vila, P. (2009). Role of V-ATPases in solid tumors: Importance of the subunit C (Review). International Journal of Oncology, 34, 1513-1520. https://doi.org/10.3892/ijo_00000280
MLA
Pérez-Sayáns, M., García-García, A., Reboiras-López, M. D., Gándara-Vila, P."Role of V-ATPases in solid tumors: Importance of the subunit C (Review)". International Journal of Oncology 34.6 (2009): 1513-1520.
Chicago
Pérez-Sayáns, M., García-García, A., Reboiras-López, M. D., Gándara-Vila, P."Role of V-ATPases in solid tumors: Importance of the subunit C (Review)". International Journal of Oncology 34, no. 6 (2009): 1513-1520. https://doi.org/10.3892/ijo_00000280
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