Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients

Ranieri,Girolamo; Ammendola,Michele; Patruno,Rosa; Celano,Giuseppe; Zito,Francesco Alfredo; Montemurro,Severino; Rella,Addolorata; Di Lecce,Valentina; Gadaleta,Cosmo Damiano; Battista De Sarro,Giovanni; Ribatti,Domenico

doi:10.3892/ijo_00000319

July 2009 Volume 35 Issue 1

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July 2009 Volume 35 Issue 1

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Article

Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients

Authors:
- Girolamo Ranieri
- Michele Ammendola
- Rosa Patruno
- Giuseppe Celano
- Francesco Alfredo Zito
- Severino Montemurro
- Addolorata Rella
- Valentina Di Lecce
- Cosmo Damiano Gadaleta
- Giovanni Battista De Sarro
- Domenico Ribatti
View Affiliations / Copyright

Affiliations: National Cancer Institute Giovanni Paolo II, 70126 Bari, Italy. giroran@tiscalinet.it
Pages: 115-120
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Published online on: July 1, 2009

https://doi.org/10.3892/ijo_00000319
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Abstract

Literature data indicate that mast cells (MCs) are involved in tumor angiogenesis due to the release of several pro-angiogenetic factors among which tryptase, a serine protease stored in MCs granules, is one of the most active. However, no data are available concerning the role of MCs in angiogenesis in primary human breast cancer. In this study, we have evaluated the correlations between the number of MCs positive to tryptase (MCDPT), the area occupied by MCs positive to tryptase (MCAPT) and microvascular density (MVD) and endothelial area (EA) in a series of 88 primary T1-3, N0-2 M0 female breast cancer, by means of immunohistochemistry and image analysis methods. Data demonstrated a significant (r = from 0.78 to 0.89; p-value from 0.001 to 0.002 by Pearson's analysis respectively) correlation between MCDPT, MCAPT, MVD, EA to each other. No correlation concerning MCDPT, MCAPT, MVD, EA and the main clinicopathological features was found. Our results suggest that tryptase-positive MCs play a role in breast cancer angiogenesis. In this context several tryptase inhibitors such as gabexate mesilate and nafamostat mesilate might be evaluated in clinical trials as a new anti-angiogenetic approach.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients

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Abstract

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