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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2009 Volume 35 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2009 Volume 35 Issue 1

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Article

Negative regulation of TIMP1 is mediated by transcription factor TWIST1

  • Authors:
    • Hirohiko Okamura
    • Kaya Yoshida
    • Tatsuji Haneji

  • View Affiliations / Copyright

    Affiliations: Department of Histology and Oral Histology, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto, Tokushima 770-8504, Japan
  • Pages: 181-186
    |
    Published online on: July 1, 2009
       https://doi.org/10.3892/ijo_00000327
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Abstract

TWIST1 is involved in tumor invasion and metastasis by promoting epithelial-to-mesenchymal transition. However, the molecular target of TWIST1 involving this mechanism is poorly understood. To identify the TWIST1-regulated genes, we established the Saos-2 cells stably expressing TWIST1 gene by transfecting TWIST1 cDNA into the cells and performed a differential display approach by using annealing control primers. Here, we report that one of the genes that were down-regulated in TWIST1 expressing cells is predicted to be TIMP1. TIMP1 has been reported as the naturally occurring specific inhibitor of matrix metalloproteinases (MMPs). Overexpression of TWIST1 gene suppressed the expression of TIMP1 mRNA but had no effect on TIMP2 and MMP-2 expression, as determined by semi-quantitative RT-PCR. We showed that TWIST1 was up-regulated in SCCBHY cells, which have a strong capacity of invasion into mandibular bone compared with SCCHN cells. Our present results suggest that TWIST1 is involved in tumor invasion by regulating the expression of TIMP1.

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Copy and paste a formatted citation
Spandidos Publications style
Okamura H, Yoshida K and Haneji T: Negative regulation of TIMP1 is mediated by transcription factor TWIST1. Int J Oncol 35: 181-186, 2009.
APA
Okamura, H., Yoshida, K., & Haneji, T. (2009). Negative regulation of TIMP1 is mediated by transcription factor TWIST1. International Journal of Oncology, 35, 181-186. https://doi.org/10.3892/ijo_00000327
MLA
Okamura, H., Yoshida, K., Haneji, T."Negative regulation of TIMP1 is mediated by transcription factor TWIST1". International Journal of Oncology 35.1 (2009): 181-186.
Chicago
Okamura, H., Yoshida, K., Haneji, T."Negative regulation of TIMP1 is mediated by transcription factor TWIST1". International Journal of Oncology 35, no. 1 (2009): 181-186. https://doi.org/10.3892/ijo_00000327
Copy and paste a formatted citation
x
Spandidos Publications style
Okamura H, Yoshida K and Haneji T: Negative regulation of TIMP1 is mediated by transcription factor TWIST1. Int J Oncol 35: 181-186, 2009.
APA
Okamura, H., Yoshida, K., & Haneji, T. (2009). Negative regulation of TIMP1 is mediated by transcription factor TWIST1. International Journal of Oncology, 35, 181-186. https://doi.org/10.3892/ijo_00000327
MLA
Okamura, H., Yoshida, K., Haneji, T."Negative regulation of TIMP1 is mediated by transcription factor TWIST1". International Journal of Oncology 35.1 (2009): 181-186.
Chicago
Okamura, H., Yoshida, K., Haneji, T."Negative regulation of TIMP1 is mediated by transcription factor TWIST1". International Journal of Oncology 35, no. 1 (2009): 181-186. https://doi.org/10.3892/ijo_00000327
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