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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2009 Volume 35 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2009 Volume 35 Issue 2

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Article Open Access

Halofuginone mediated protection against radiation-induced leg contracture

  • Authors:
    • Hisanari Ishii
    • Rajani Choudhuri
    • Askale Mathias
    • Anastasia L. Sowers
    • Kathleen C. Flanders
    • John A. Cook
    • James B. Mitchell

  • View Affiliations / Copyright

    Affiliations: Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-1002, USA
  • Pages: 315-319
    |
    Published online on: August 1, 2009
       https://doi.org/10.3892/ijo_00000342
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Abstract

Fibrosis of normal tissues often accompanies radiation treatment of cancer. Activation of the transforming growth factor-β (TGF-β) signaling pathway is thought to play a major role in radiation-induced fibrosis and has prompted the development and assessment of low molecular weight inhibitors of the pathway. Previous studies with halofuginone have shown it to inhibit TGF-β signaling in vitro and protect mice from radiation-induced leg contraction (a model for soft tissue fibrosis). The current study confirms these findings for HaCaT cells stimulated with exogenous TGF-β treatment. Reducing the halifuginone treatment from 7 days/week (used previously) to 5 days/week post-radiation exposure provided significant protection against radiation-induced leg contraction in mice 3 and 4 months post-radiation treatment. Halofuginone treatment was shown to attenuate TGF-β signaling molecules taken from irradiated skin including TGF-βRII, pSmad3, Smad7, and TSP1. The latter, TSP1, a co-activator of TGF-β may serve as a suitable biomarker for monitoring the efficacy of halofuginone should it be evaluated in a clinical setting for protection against radiation-induced fibrosis.

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Copy and paste a formatted citation
Spandidos Publications style
Ishii H, Choudhuri R, Mathias A, Sowers AL, Flanders KC, Cook JA and Mitchell JB: Halofuginone mediated protection against radiation-induced leg contracture. Int J Oncol 35: 315-319, 2009.
APA
Ishii, H., Choudhuri, R., Mathias, A., Sowers, A.L., Flanders, K.C., Cook, J.A., & Mitchell, J.B. (2009). Halofuginone mediated protection against radiation-induced leg contracture. International Journal of Oncology, 35, 315-319. https://doi.org/10.3892/ijo_00000342
MLA
Ishii, H., Choudhuri, R., Mathias, A., Sowers, A. L., Flanders, K. C., Cook, J. A., Mitchell, J. B."Halofuginone mediated protection against radiation-induced leg contracture". International Journal of Oncology 35.2 (2009): 315-319.
Chicago
Ishii, H., Choudhuri, R., Mathias, A., Sowers, A. L., Flanders, K. C., Cook, J. A., Mitchell, J. B."Halofuginone mediated protection against radiation-induced leg contracture". International Journal of Oncology 35, no. 2 (2009): 315-319. https://doi.org/10.3892/ijo_00000342
Copy and paste a formatted citation
x
Spandidos Publications style
Ishii H, Choudhuri R, Mathias A, Sowers AL, Flanders KC, Cook JA and Mitchell JB: Halofuginone mediated protection against radiation-induced leg contracture. Int J Oncol 35: 315-319, 2009.
APA
Ishii, H., Choudhuri, R., Mathias, A., Sowers, A.L., Flanders, K.C., Cook, J.A., & Mitchell, J.B. (2009). Halofuginone mediated protection against radiation-induced leg contracture. International Journal of Oncology, 35, 315-319. https://doi.org/10.3892/ijo_00000342
MLA
Ishii, H., Choudhuri, R., Mathias, A., Sowers, A. L., Flanders, K. C., Cook, J. A., Mitchell, J. B."Halofuginone mediated protection against radiation-induced leg contracture". International Journal of Oncology 35.2 (2009): 315-319.
Chicago
Ishii, H., Choudhuri, R., Mathias, A., Sowers, A. L., Flanders, K. C., Cook, J. A., Mitchell, J. B."Halofuginone mediated protection against radiation-induced leg contracture". International Journal of Oncology 35, no. 2 (2009): 315-319. https://doi.org/10.3892/ijo_00000342
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