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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2009 Volume 35 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2009 Volume 35 Issue 3

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Article

Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: Sensitization by the MDL 72527 lysosomotropic compound

  • Authors:
    • Enzo Agostinelli
    • Maria Condello
    • Agnese Molinari
    • Giampiero Tempera
    • Nikenza Viceconte
    • Giuseppe Arancia

  • View Affiliations / Copyright

    Affiliations: Department of Biochemical Sciences ‘A. Rossi Fanelli’, Sapienza University of Rome, I-00185 Rome, Italy. enzo.agostinelli@uniroma1.it
  • Pages: 485-498
    |
    Published online on: September 1, 2009
       https://doi.org/10.3892/ijo_00000360
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Abstract

It has been confirmed that multidrug resistant (MDR) human melanoma cells are more sensitive than their wild-type counterparts to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine. The metabolites formed by BSAO and spermine are more toxic than exogenous H2O2 and acrolein, even though their concentration is lower during the initial phase of incubation due to their more gradual release than the exogenous products. Both wild-type and MDR cells, after pre-treatment with MDL 72527, an inactivator of polyamine oxidase and a lysosomotropic compound, show to be sensitized to subsequent exposure to BSAO/spermine. Evidence of ultrastructural aberrations and acridine orange release from lysosomes is presented in this work that is in favor of the permeabilization of the lysosomal membrane as the major cause of sensitization by MDL 72527. Owing to its lysosomotropic effect, pre-treatment with MDL 72527 amplifies the ability of the metabolites formed from spermine by oxidative deamination to induce cell death. Since it is conceivable that combined treatment with a lysosomotropic compound and BSAO/spermine would be effective against tumor cells, it is of interest to search for such novel compounds, which might be promising for application in a therapeutic setting.

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Copy and paste a formatted citation
Spandidos Publications style
Agostinelli E, Condello M, Molinari A, Tempera G, Viceconte N and Arancia G: Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: Sensitization by the MDL 72527 lysosomotropic compound. Int J Oncol 35: 485-498, 2009.
APA
Agostinelli, E., Condello, M., Molinari, A., Tempera, G., Viceconte, N., & Arancia, G. (2009). Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: Sensitization by the MDL 72527 lysosomotropic compound. International Journal of Oncology, 35, 485-498. https://doi.org/10.3892/ijo_00000360
MLA
Agostinelli, E., Condello, M., Molinari, A., Tempera, G., Viceconte, N., Arancia, G."Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: Sensitization by the MDL 72527 lysosomotropic compound". International Journal of Oncology 35.3 (2009): 485-498.
Chicago
Agostinelli, E., Condello, M., Molinari, A., Tempera, G., Viceconte, N., Arancia, G."Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: Sensitization by the MDL 72527 lysosomotropic compound". International Journal of Oncology 35, no. 3 (2009): 485-498. https://doi.org/10.3892/ijo_00000360
Copy and paste a formatted citation
x
Spandidos Publications style
Agostinelli E, Condello M, Molinari A, Tempera G, Viceconte N and Arancia G: Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: Sensitization by the MDL 72527 lysosomotropic compound. Int J Oncol 35: 485-498, 2009.
APA
Agostinelli, E., Condello, M., Molinari, A., Tempera, G., Viceconte, N., & Arancia, G. (2009). Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: Sensitization by the MDL 72527 lysosomotropic compound. International Journal of Oncology, 35, 485-498. https://doi.org/10.3892/ijo_00000360
MLA
Agostinelli, E., Condello, M., Molinari, A., Tempera, G., Viceconte, N., Arancia, G."Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: Sensitization by the MDL 72527 lysosomotropic compound". International Journal of Oncology 35.3 (2009): 485-498.
Chicago
Agostinelli, E., Condello, M., Molinari, A., Tempera, G., Viceconte, N., Arancia, G."Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: Sensitization by the MDL 72527 lysosomotropic compound". International Journal of Oncology 35, no. 3 (2009): 485-498. https://doi.org/10.3892/ijo_00000360
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