Diagnostic importance of overexpression of Bmi-1 mRNA in early breast cancers

  • Authors:
    • Masachika Saeki
    • Daisuke Kobayashi
    • Naoki Tsuji
    • Kageaki Kuribayashi
    • Naoki Watanabe
  • View Affiliations

  • Published online on: September 1, 2009     https://doi.org/10.3892/ijo_00000362
  • Pages: 511-515
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Target molecules for a highly sensitive and specific diagnosis of breast cancer in its early clinical stages have not yet been identified. Here, we show the first evidence for diagnostic performance of the molecule B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) in breast cancer patients. Only 5 out of 46 non-cancerous samples were positive for Bmi-1 mRNA expression resulting in a sensitivity and specificity of 72.0 and 91.3%, respectively. The mRNA expression was estimated using the cut-off value obtained from the receiver operating characteristic curve analysis. Further, Bmi-1 mRNA expression was found to be elevated in 97.8% (45/46) of cancerous tissues in comparison to the expression in paired cancerous tissues and non-cancerous tissues obtained from identical patients. Bmi-1 mRNA was found to be highly expressed even in the early clinical stages of breast cancer. Our results suggest that Bmi-1 mRNA might be a new tool to support the diagnosis of breast cancers, irrespective of the clinical stage.

Related Articles

Journal Cover

September 2009
Volume 35 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Saeki M, Kobayashi D, Tsuji N, Kuribayashi K and Watanabe N: Diagnostic importance of overexpression of Bmi-1 mRNA in early breast cancers. Int J Oncol 35: 511-515, 2009
APA
Saeki, M., Kobayashi, D., Tsuji, N., Kuribayashi, K., & Watanabe, N. (2009). Diagnostic importance of overexpression of Bmi-1 mRNA in early breast cancers. International Journal of Oncology, 35, 511-515. https://doi.org/10.3892/ijo_00000362
MLA
Saeki, M., Kobayashi, D., Tsuji, N., Kuribayashi, K., Watanabe, N."Diagnostic importance of overexpression of Bmi-1 mRNA in early breast cancers". International Journal of Oncology 35.3 (2009): 511-515.
Chicago
Saeki, M., Kobayashi, D., Tsuji, N., Kuribayashi, K., Watanabe, N."Diagnostic importance of overexpression of Bmi-1 mRNA in early breast cancers". International Journal of Oncology 35, no. 3 (2009): 511-515. https://doi.org/10.3892/ijo_00000362