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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2010 Volume 36 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2010 Volume 36 Issue 2

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Article

Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer

  • Authors:
    • Pei-Jou Chua
    • Eng-Hong Lee
    • Yingnan Yu
    • George Wai-Cheong Yip
    • Puay-Hoon Tan
    • Boon-Huat Bay

  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, MD10, S 117 597, Singapore
  • Pages: 359-364
    |
    Published online on: February 1, 2010
       https://doi.org/10.3892/ijo_00000507
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Abstract

Peroxiredoxin III (Prx III), an antioxidant protein found in mitochondria, plays an essential role in mitochondrial homeostasis. Aberrant expression of Prx III has been implicated in the tumorigenesis of various cancers. In this study, we evaluated the expression of Prx III in breast cancer tissues and elucidated its role in cell proliferation, a hallmark of cancer. Breast tissue microarrays comprising 106 breast cancer sections were stained with Prx III antibody using immunohistochemisty and correlated with proliferating cell nuclear antigen (PCNA) immunostaining. To validate the role of Prx III in cell proliferation, expression of Prx III was analyzed at the mRNA and protein levels by real-time RT-PCR, Western blotting and immunofluorescence in vitro. siRNA mediated silencing of Prx III in MDA-MB-231 breast cancer cells was performed and the effect on the cell cycle was examined. Prx III expression in patient tissue microarray samples was found to be positively associated with PCNA immunostaining, a proliferative marker. Prx III was expressed in both MCF-7 and MDA-MB-231 breast cancer cell lines and transient transfection with siPrx III in MDA-MB-231 cells induced inhibition of cell proliferation and cell cycle arrest. The data suggests that Prx III has a significant role in cell cycle regulation and could be a potential proliferation marker in breast cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Chua P, Lee E, Yu Y, Yip GW, Tan P and Bay B: Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer. Int J Oncol 36: 359-364, 2010.
APA
Chua, P., Lee, E., Yu, Y., Yip, G.W., Tan, P., & Bay, B. (2010). Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer. International Journal of Oncology, 36, 359-364. https://doi.org/10.3892/ijo_00000507
MLA
Chua, P., Lee, E., Yu, Y., Yip, G. W., Tan, P., Bay, B."Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer". International Journal of Oncology 36.2 (2010): 359-364.
Chicago
Chua, P., Lee, E., Yu, Y., Yip, G. W., Tan, P., Bay, B."Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer". International Journal of Oncology 36, no. 2 (2010): 359-364. https://doi.org/10.3892/ijo_00000507
Copy and paste a formatted citation
x
Spandidos Publications style
Chua P, Lee E, Yu Y, Yip GW, Tan P and Bay B: Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer. Int J Oncol 36: 359-364, 2010.
APA
Chua, P., Lee, E., Yu, Y., Yip, G.W., Tan, P., & Bay, B. (2010). Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer. International Journal of Oncology, 36, 359-364. https://doi.org/10.3892/ijo_00000507
MLA
Chua, P., Lee, E., Yu, Y., Yip, G. W., Tan, P., Bay, B."Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer". International Journal of Oncology 36.2 (2010): 359-364.
Chicago
Chua, P., Lee, E., Yu, Y., Yip, G. W., Tan, P., Bay, B."Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer". International Journal of Oncology 36, no. 2 (2010): 359-364. https://doi.org/10.3892/ijo_00000507
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