An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer

  • Authors:
    • Xianglan Zhang
    • Jung-Jin Yang
    • Yoon Sun Kim
    • Ki-Yeol Kim
    • Woong Shick Ahn
    • Sanghwa Yang
  • View Affiliations

  • Published online on: February 1, 2010     https://doi.org/10.3892/ijo_00000513
  • Pages: 405-414
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Abstract

We have identified an 8-gene signature with significant expression differences between gastric cancer and normal gastric tissues. This 8-gene set can predict the normal and cancer status of gastric tissues with more than 96% accuracy in a totally independent microarray dataset. The 8 genes are composed of down-regulated KLF4, GPX3, SST and LIPF, together with up-regulated SERPINH1, THY1 and INHBA in gastric cancer. To corroborate the differential gene expression pattern, we chose GPX3 and examined its expression pattern in detail. A comparison of GPX3 expression pattern shows a broader down-regulated pattern in multiple types of cancers, including cervical, thyroid, head and neck, lung cancers and melanoma than in healthy controls. An immuno-histostaining analysis in tissue microarrays confirms GPX3 down-regulation in gastric cancer. Mechanism-wise GPX3 down-regulation in gastric cancer is due to promoter hypermethylation. Collectively, these results show a correct identification of 8 genes as gastric cancer biomarkers.

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February 2010
Volume 36 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang X, Yang J, Kim YS, Kim K, Ahn WS and Yang S: An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer. Int J Oncol 36: 405-414, 2010.
APA
Zhang, X., Yang, J., Kim, Y.S., Kim, K., Ahn, W.S., & Yang, S. (2010). An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer. International Journal of Oncology, 36, 405-414. https://doi.org/10.3892/ijo_00000513
MLA
Zhang, X., Yang, J., Kim, Y. S., Kim, K., Ahn, W. S., Yang, S."An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer". International Journal of Oncology 36.2 (2010): 405-414.
Chicago
Zhang, X., Yang, J., Kim, Y. S., Kim, K., Ahn, W. S., Yang, S."An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer". International Journal of Oncology 36, no. 2 (2010): 405-414. https://doi.org/10.3892/ijo_00000513