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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2010 Volume 36 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2010 Volume 36 Issue 6

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Article

E6/E7 mRNA expression analysis: A test for the objective assessment of cervical adenocarcinoma in clinical prognostic procedure

  • Authors:
    • Siri Hovland
    • Susanne Muller
    • Hanne Skomedal
    • Michael Mints
    • Jakob Bergström
    • Keng-Ling Wallin
    • Frank Karlsen
    • Bo Johansson
    • Sonia Andersson

  • View Affiliations / Copyright

    Affiliations: NorChip AS, Klokkarstua, Norway
  • Pages: 1533-1539
    |
    Published online on: June 1, 2010
       https://doi.org/10.3892/ijo_00000640
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Abstract

Detection of E6/E7 mRNA expression using the real-time nucleic acid sequence-based amplification assay (NASBA) PreTect HPV-Proofer was compared with results of human papillomavirus (HPV) DNA detection in 98 paraffin-embedded samples from patients with cervical adenocarcinoma. HR-HPV DNA was detected in 61 (62%), while HR-HPV E6/E7 mRNA was detected in 63 (64%) of the samples. Correlation between results from DNA analyses and the E6/E7 mRNA assay showed consistent results in 87% of samples (47 of 54). The results from these two methods in detecting presence of HPV infection of any type agreed in 77%. Overall agreement between the methods was seen in 82 of the 98 cases (84%). When evaluating change in sensitivity for detection of HPV positives by adding more HPV types to the HPV DNA assay, maximum sensitivity was reached by targeting four HPV types. The coverage of HPV DNA presence was 76.9%, while the E6/E7 mRNA assay achieved a maximum coverage of 80.8% using only three HPV types. Thus, E6/E7 oncogene expression analysis may provide a more objective test for assessment of neoplastic glandular cells. Further studies may reveal whether the clinical performance of the E6/E7 mRNA assay will be of prognostic value in management of cervical adenocarcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Hovland S, Muller S, Skomedal H, Mints M, Bergström J, Wallin K, Karlsen F, Johansson B and Andersson S: E6/E7 mRNA expression analysis: A test for the objective assessment of cervical adenocarcinoma in clinical prognostic procedure. Int J Oncol 36: 1533-1539, 2010.
APA
Hovland, S., Muller, S., Skomedal, H., Mints, M., Bergström, J., Wallin, K. ... Andersson, S. (2010). E6/E7 mRNA expression analysis: A test for the objective assessment of cervical adenocarcinoma in clinical prognostic procedure. International Journal of Oncology, 36, 1533-1539. https://doi.org/10.3892/ijo_00000640
MLA
Hovland, S., Muller, S., Skomedal, H., Mints, M., Bergström, J., Wallin, K., Karlsen, F., Johansson, B., Andersson, S."E6/E7 mRNA expression analysis: A test for the objective assessment of cervical adenocarcinoma in clinical prognostic procedure". International Journal of Oncology 36.6 (2010): 1533-1539.
Chicago
Hovland, S., Muller, S., Skomedal, H., Mints, M., Bergström, J., Wallin, K., Karlsen, F., Johansson, B., Andersson, S."E6/E7 mRNA expression analysis: A test for the objective assessment of cervical adenocarcinoma in clinical prognostic procedure". International Journal of Oncology 36, no. 6 (2010): 1533-1539. https://doi.org/10.3892/ijo_00000640
Copy and paste a formatted citation
x
Spandidos Publications style
Hovland S, Muller S, Skomedal H, Mints M, Bergström J, Wallin K, Karlsen F, Johansson B and Andersson S: E6/E7 mRNA expression analysis: A test for the objective assessment of cervical adenocarcinoma in clinical prognostic procedure. Int J Oncol 36: 1533-1539, 2010.
APA
Hovland, S., Muller, S., Skomedal, H., Mints, M., Bergström, J., Wallin, K. ... Andersson, S. (2010). E6/E7 mRNA expression analysis: A test for the objective assessment of cervical adenocarcinoma in clinical prognostic procedure. International Journal of Oncology, 36, 1533-1539. https://doi.org/10.3892/ijo_00000640
MLA
Hovland, S., Muller, S., Skomedal, H., Mints, M., Bergström, J., Wallin, K., Karlsen, F., Johansson, B., Andersson, S."E6/E7 mRNA expression analysis: A test for the objective assessment of cervical adenocarcinoma in clinical prognostic procedure". International Journal of Oncology 36.6 (2010): 1533-1539.
Chicago
Hovland, S., Muller, S., Skomedal, H., Mints, M., Bergström, J., Wallin, K., Karlsen, F., Johansson, B., Andersson, S."E6/E7 mRNA expression analysis: A test for the objective assessment of cervical adenocarcinoma in clinical prognostic procedure". International Journal of Oncology 36, no. 6 (2010): 1533-1539. https://doi.org/10.3892/ijo_00000640
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