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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2010 Volume 37 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2010 Volume 37 Issue 1

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Article

Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival

  • Authors:
    • Lucyana Conceição Farias
    • Carlos Alberto De Carvalho Fraga
    • Marcos Vinícius Macedo De Oliveira
    • Thiago Fonseca Silva
    • Luciano Marques-Silva
    • Paula Rocha Moreira
    • Alfredo Maurício Batista De-Paula
    • Ricardo Santiago Gomez
    • André Luiz Sena Guimarães

  • View Affiliations / Copyright

    Affiliations: Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil
  • Pages: 167-176
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/ijo_00000664
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Abstract

De novo DNA methylation is a relevant epigenetic mechanism, which represses gene transcription and commonly inactivates tumor suppressor genes in carcinogenesis. A single nucleotide polymorphism of DNMT3B, C46359T (−149C↷T) was reported to modulate individual's susceptibility to cancer. We investigated the role of this polymorphic variant regarding the methylation status of the p16CDKN2A gene in young and older patients with head and neck squamous cell carcinoma (HNCC) matched by the TNM staging system, together with its impact on patients survival. The results showed that the presence of the allele T of the polymorphism DNMT3B (−149C↷T) was associated with advanced TNM staging and smoking habit, but no association was found between this polymorphisms and DNMT3B immunostaining. While p16CDKN2A methylation was significantly associated with smoking habit in older patients, this parameter was associated with family history of cancer in young patients. Moreover, in older patients the absence of p16CDKN2A promoter methylation had a negative impact on survival. In conclusion, nucleotide polymorphism of DNMT3B is not associated with methylation of p16CDKN2A gene in HNSCC. The association of p16CDKN2A gene methylation with smoking, family history of cancer and survival is dependent on age.

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Copy and paste a formatted citation
Spandidos Publications style
Farias LC, De Carvalho Fraga CA, De Oliveira MV, Silva TF, Marques-Silva L, Moreira PR, De-Paula AM, Gomez RS and Guimarães AL: Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival. Int J Oncol 37: 167-176, 2010.
APA
Farias, L.C., De Carvalho Fraga, C.A., De Oliveira, M.V., Silva, T.F., Marques-Silva, L., Moreira, P.R. ... Guimarães, A.L. (2010). Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival. International Journal of Oncology, 37, 167-176. https://doi.org/10.3892/ijo_00000664
MLA
Farias, L. C., De Carvalho Fraga, C. A., De Oliveira, M. V., Silva, T. F., Marques-Silva, L., Moreira, P. R., De-Paula, A. M., Gomez, R. S., Guimarães, A. L."Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival". International Journal of Oncology 37.1 (2010): 167-176.
Chicago
Farias, L. C., De Carvalho Fraga, C. A., De Oliveira, M. V., Silva, T. F., Marques-Silva, L., Moreira, P. R., De-Paula, A. M., Gomez, R. S., Guimarães, A. L."Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival". International Journal of Oncology 37, no. 1 (2010): 167-176. https://doi.org/10.3892/ijo_00000664
Copy and paste a formatted citation
x
Spandidos Publications style
Farias LC, De Carvalho Fraga CA, De Oliveira MV, Silva TF, Marques-Silva L, Moreira PR, De-Paula AM, Gomez RS and Guimarães AL: Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival. Int J Oncol 37: 167-176, 2010.
APA
Farias, L.C., De Carvalho Fraga, C.A., De Oliveira, M.V., Silva, T.F., Marques-Silva, L., Moreira, P.R. ... Guimarães, A.L. (2010). Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival. International Journal of Oncology, 37, 167-176. https://doi.org/10.3892/ijo_00000664
MLA
Farias, L. C., De Carvalho Fraga, C. A., De Oliveira, M. V., Silva, T. F., Marques-Silva, L., Moreira, P. R., De-Paula, A. M., Gomez, R. S., Guimarães, A. L."Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival". International Journal of Oncology 37.1 (2010): 167-176.
Chicago
Farias, L. C., De Carvalho Fraga, C. A., De Oliveira, M. V., Silva, T. F., Marques-Silva, L., Moreira, P. R., De-Paula, A. M., Gomez, R. S., Guimarães, A. L."Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival". International Journal of Oncology 37, no. 1 (2010): 167-176. https://doi.org/10.3892/ijo_00000664
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