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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2010 Volume 37 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2010 Volume 37 Issue 1

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Article

Liposomal M-V-05: Formulation development and activity testing of a novel dihydrofolate reductase inhibitor for breast cancer therapy

  • Authors:
    • Bee Jen Tan
    • Kiah Shen Quek
    • Man-Yi Wong
    • Wai Keung Chui
    • Gigi N.C. Chiu

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore 117543
  • Pages: 211-218
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/ijo_00000669
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Abstract

In the management of metastatic breast cancer, fewer recognized therapeutic standards are available as compared to the early stages of the disease. Thus, it is pertinent to search for new, effective therapy to improve survival, tolerability and quality of life of patients. In this study, a liposomal formulation was developed for a novel dihydrofolate reductase (DHFR) inhibitor, M-V-05. Drug encapsulation into liposomes was achieved by the citrate-based, pH gradient loading technique, with a final drug-to-lipid weight ratio of 0.1:1. The liposome formulation exhibited a sustained release profile of the encapsulated drug that followed first order release kinetics. Liposomal M-V-05 was found to be more effective than the standard DHFR inhibitor, methotrexate, and its activity was comparable to liposomal doxorubicin, with IC50 values of 37 and 59 µM achieved in MDA-MB-231 and JIMT-1 cells, respectively. Similar cytotoxicity was observed in primary patient samples of invasive ductal carcinoma of the breast. The combination of liposomal M-V-05 and liposomal doxorubicin in fixed molar ratio of 3:1 was additive in cytotoxicity, allowing the concentrations of liposomal doxorubicin and liposomal M-V-05 to be reduced by 62 and 46%, respectively. Taken together, liposomal M-V-05 represents a promising agent and offers a potential new adjuvant therapy for breast cancer treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Tan BJ, Quek KS, Wong M, Chui WK and Chiu GN: Liposomal M-V-05: Formulation development and activity testing of a novel dihydrofolate reductase inhibitor for breast cancer therapy. Int J Oncol 37: 211-218, 2010.
APA
Tan, B.J., Quek, K.S., Wong, M., Chui, W.K., & Chiu, G.N. (2010). Liposomal M-V-05: Formulation development and activity testing of a novel dihydrofolate reductase inhibitor for breast cancer therapy. International Journal of Oncology, 37, 211-218. https://doi.org/10.3892/ijo_00000669
MLA
Tan, B. J., Quek, K. S., Wong, M., Chui, W. K., Chiu, G. N."Liposomal M-V-05: Formulation development and activity testing of a novel dihydrofolate reductase inhibitor for breast cancer therapy". International Journal of Oncology 37.1 (2010): 211-218.
Chicago
Tan, B. J., Quek, K. S., Wong, M., Chui, W. K., Chiu, G. N."Liposomal M-V-05: Formulation development and activity testing of a novel dihydrofolate reductase inhibitor for breast cancer therapy". International Journal of Oncology 37, no. 1 (2010): 211-218. https://doi.org/10.3892/ijo_00000669
Copy and paste a formatted citation
x
Spandidos Publications style
Tan BJ, Quek KS, Wong M, Chui WK and Chiu GN: Liposomal M-V-05: Formulation development and activity testing of a novel dihydrofolate reductase inhibitor for breast cancer therapy. Int J Oncol 37: 211-218, 2010.
APA
Tan, B.J., Quek, K.S., Wong, M., Chui, W.K., & Chiu, G.N. (2010). Liposomal M-V-05: Formulation development and activity testing of a novel dihydrofolate reductase inhibitor for breast cancer therapy. International Journal of Oncology, 37, 211-218. https://doi.org/10.3892/ijo_00000669
MLA
Tan, B. J., Quek, K. S., Wong, M., Chui, W. K., Chiu, G. N."Liposomal M-V-05: Formulation development and activity testing of a novel dihydrofolate reductase inhibitor for breast cancer therapy". International Journal of Oncology 37.1 (2010): 211-218.
Chicago
Tan, B. J., Quek, K. S., Wong, M., Chui, W. K., Chiu, G. N."Liposomal M-V-05: Formulation development and activity testing of a novel dihydrofolate reductase inhibitor for breast cancer therapy". International Journal of Oncology 37, no. 1 (2010): 211-218. https://doi.org/10.3892/ijo_00000669
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