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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2010 Volume 37 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2010 Volume 37 Issue 2

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Article

Glucose metabolism of malignant cells is not regulated by transketolase-like (TKTL)-1

  • Authors:
    • Arnulf Mayer
    • Angelika Von Wallbrunn
    • Peter Vaupel

  • View Affiliations / Copyright

    Affiliations: Department of Radiooncology and Radiotherapy, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany. arnmayer@uni-mainz.de
  • Pages: 265-271
    |
    Published online on: August 1, 2010
       https://doi.org/10.3892/ijo_00000674
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Abstract

An isoenzyme of transketolase, transketolase-like (TKTL)-1, has been hypothesized to play a pivotal role in the pathophysiology of malignant tumors. Available data are based on the detection of the putative TKTL-1 protein with one particular mouse monoclonal anti-TKTL-1 antibody, clone JFC12T10. In this study it was demonstrated that a) JFC12T10 detects multiple unspecific bands in Western blots, b) a 75-kDa band hitherto referred to as TKTL-1 corresponds to a nuclear protein and c) immunohistochemical detection of TKTL-1 in benign leiomyomas yields an expression pattern identical to that found in a variety of malignant tumors. In RT-PCR assays, using three different primer pairs for transketolase, TKTL-1 and yet another isogene of transketolase, TKTL-2, a relevant expression of TKTL-1 was not detectable in any of the 6 malignant tumor cell lines investigated (MCF-7, A549, HeLa, HT1080, M21 and TF-1). Expression levels of TKTL-1 were rather similar to those found for TKTL-2, although the latter has never been implicated in malignant disease. On the basis of these data, nutritional recommendations based on a hypothetically TKTL-1 controlled metabolism of tumor cells must be regarded as lacking scientific evidence.

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Copy and paste a formatted citation
Spandidos Publications style
Mayer A, Von Wallbrunn A and Vaupel P: Glucose metabolism of malignant cells is not regulated by transketolase-like (TKTL)-1. Int J Oncol 37: 265-271, 2010.
APA
Mayer, A., Von Wallbrunn, A., & Vaupel, P. (2010). Glucose metabolism of malignant cells is not regulated by transketolase-like (TKTL)-1. International Journal of Oncology, 37, 265-271. https://doi.org/10.3892/ijo_00000674
MLA
Mayer, A., Von Wallbrunn, A., Vaupel, P."Glucose metabolism of malignant cells is not regulated by transketolase-like (TKTL)-1". International Journal of Oncology 37.2 (2010): 265-271.
Chicago
Mayer, A., Von Wallbrunn, A., Vaupel, P."Glucose metabolism of malignant cells is not regulated by transketolase-like (TKTL)-1". International Journal of Oncology 37, no. 2 (2010): 265-271. https://doi.org/10.3892/ijo_00000674
Copy and paste a formatted citation
x
Spandidos Publications style
Mayer A, Von Wallbrunn A and Vaupel P: Glucose metabolism of malignant cells is not regulated by transketolase-like (TKTL)-1. Int J Oncol 37: 265-271, 2010.
APA
Mayer, A., Von Wallbrunn, A., & Vaupel, P. (2010). Glucose metabolism of malignant cells is not regulated by transketolase-like (TKTL)-1. International Journal of Oncology, 37, 265-271. https://doi.org/10.3892/ijo_00000674
MLA
Mayer, A., Von Wallbrunn, A., Vaupel, P."Glucose metabolism of malignant cells is not regulated by transketolase-like (TKTL)-1". International Journal of Oncology 37.2 (2010): 265-271.
Chicago
Mayer, A., Von Wallbrunn, A., Vaupel, P."Glucose metabolism of malignant cells is not regulated by transketolase-like (TKTL)-1". International Journal of Oncology 37, no. 2 (2010): 265-271. https://doi.org/10.3892/ijo_00000674
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