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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2010 Volume 37 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2010 Volume 37 Issue 3

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Article

Molecular characterization of tumors from a transgenic mouse adrenal tumor model: Comparison with human pheochromocytoma

  • Authors:
    • Yoshiyuki Hattori
    • Naotetsu Kanamoto
    • Kumi Kawano
    • Hiroshi Iwakura
    • Masakatsu Sone
    • Masako Miura
    • Akihiro Yasoda
    • Naohisa Tamura
    • Hiroshi Arai
    • Takashi Akamizu
    • Kazuwa Nakao
    • Yoshie Maitani

  • View Affiliations / Copyright

    Affiliations: Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan. yhattori@hoshi.ac.jp
  • Pages: 695-705
    |
    Published online on: September 1, 2010
       https://doi.org/10.3892/ijo_00000719
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Abstract

Adrenal neuroblastoma and pheochromocytoma have the same embryonic origin from neural crest cells and mainly arise from the adrenal medulla. Recently, transgenic mice exhibiting tumors in the bilateral adrenal medulla by the expression of SV40 T-antigen were developed. In this study, we investigated mRNA expression in adrenal tumors of transgenic mice and compared them with human pheochromocytoma by DNA microarray analysis. To compare mouse adrenal tumors and human pheochromacytoma, we found that the expressions of noradrenergic neuron-related genes, including dopa decarboxylase, phenylethanolamine-N-methyltransferase and chromogranin B, were up-regulated in humans but not in mice; however, the expression of neuroblastoma-related genes, including Mycn, paired-like homeobox 2b, γ-aminobutyric acid A receptor β3 subunit, islet 1 and kinesin family member 1A, was up-regulated in both species. From the gene expression profiles, the characterization of mouse adrenal tumor, may be similar to that of human adrenal neuroblastoma rather than pheochromacytomas. This mouse model would be a useful tool for the development of anti-cancer drugs and for understanding the etiology of adrenal neuroblastoma.

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Copy and paste a formatted citation
Spandidos Publications style
Hattori Y, Kanamoto N, Kawano K, Iwakura H, Sone M, Miura M, Yasoda A, Tamura N, Arai H, Akamizu T, Akamizu T, et al: Molecular characterization of tumors from a transgenic mouse adrenal tumor model: Comparison with human pheochromocytoma. Int J Oncol 37: 695-705, 2010.
APA
Hattori, Y., Kanamoto, N., Kawano, K., Iwakura, H., Sone, M., Miura, M. ... Maitani, Y. (2010). Molecular characterization of tumors from a transgenic mouse adrenal tumor model: Comparison with human pheochromocytoma. International Journal of Oncology, 37, 695-705. https://doi.org/10.3892/ijo_00000719
MLA
Hattori, Y., Kanamoto, N., Kawano, K., Iwakura, H., Sone, M., Miura, M., Yasoda, A., Tamura, N., Arai, H., Akamizu, T., Nakao, K., Maitani, Y."Molecular characterization of tumors from a transgenic mouse adrenal tumor model: Comparison with human pheochromocytoma". International Journal of Oncology 37.3 (2010): 695-705.
Chicago
Hattori, Y., Kanamoto, N., Kawano, K., Iwakura, H., Sone, M., Miura, M., Yasoda, A., Tamura, N., Arai, H., Akamizu, T., Nakao, K., Maitani, Y."Molecular characterization of tumors from a transgenic mouse adrenal tumor model: Comparison with human pheochromocytoma". International Journal of Oncology 37, no. 3 (2010): 695-705. https://doi.org/10.3892/ijo_00000719
Copy and paste a formatted citation
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Spandidos Publications style
Hattori Y, Kanamoto N, Kawano K, Iwakura H, Sone M, Miura M, Yasoda A, Tamura N, Arai H, Akamizu T, Akamizu T, et al: Molecular characterization of tumors from a transgenic mouse adrenal tumor model: Comparison with human pheochromocytoma. Int J Oncol 37: 695-705, 2010.
APA
Hattori, Y., Kanamoto, N., Kawano, K., Iwakura, H., Sone, M., Miura, M. ... Maitani, Y. (2010). Molecular characterization of tumors from a transgenic mouse adrenal tumor model: Comparison with human pheochromocytoma. International Journal of Oncology, 37, 695-705. https://doi.org/10.3892/ijo_00000719
MLA
Hattori, Y., Kanamoto, N., Kawano, K., Iwakura, H., Sone, M., Miura, M., Yasoda, A., Tamura, N., Arai, H., Akamizu, T., Nakao, K., Maitani, Y."Molecular characterization of tumors from a transgenic mouse adrenal tumor model: Comparison with human pheochromocytoma". International Journal of Oncology 37.3 (2010): 695-705.
Chicago
Hattori, Y., Kanamoto, N., Kawano, K., Iwakura, H., Sone, M., Miura, M., Yasoda, A., Tamura, N., Arai, H., Akamizu, T., Nakao, K., Maitani, Y."Molecular characterization of tumors from a transgenic mouse adrenal tumor model: Comparison with human pheochromocytoma". International Journal of Oncology 37, no. 3 (2010): 695-705. https://doi.org/10.3892/ijo_00000719
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