Maxillary pain is the first indication of the presence of multiple myeloma: A case report

  • Authors:
    • Xiao Jiao Zhao
    • Jian Sun
    • Ying Deng Wang
    • Li Wang
  • View Affiliations

  • Published online on: October 14, 2013     https://doi.org/10.3892/mco.2013.200
  • Pages:59-64
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Abstract

Multiple myeloma is a primary malignancy of bone marrow characterized by the clonal proliferation of plasma cells and production of monoclonal immunoglobulin. The disease occurs more frequently in males, with the average age at diagnosis being ~60 years. The first manifestation of multiple myeloma is varied and depends on the sites and extent of involvement. The predominant clinical symptoms of multiple myeloma are associated with bone pain and renal dysfunction. Neoplastic cells usually produce large amounts of monoclonal immunoglobulin light or heavy chains that can be detected in serum or urine, while plasmacytoma may be identified on marrow biopsy. The present study reported on the case of a 69‑year‑old male patient presenting with a complaint of a painful lesion in the left maxilla. Physical examination, imaging, laboratory investigations and biopsy were conducted, confirming the diagnosis of multiple myeloma. The results obtained suggest that the dentist should address oral manifestations as first indications of multiple myeloma.

Introduction

Multiple myeloma involves the clonal proliferation of plasma cells based in the bone marrow, with various degrees of differentiation (1). Neoplastic cells usually produce large amounts of monoclonal immunoglobulin light or heavy chains that can be detected in serum or urine (2). Although multiple myeloma is the most common primary bone cancer in adults, in ∼95% of cases, it involves several bones (3).

The etiology of this disease remains to be determined. However, some occupations, exposure to certain chemicals, overdose irradiation, viruses and genetic factors are considered to be etiologic factors (4).

Myeloma is slightly more prevalent in males and individuals of African-American descent (5). In western countries, the disease is more prevalent in males, with a median and average age at diagnosis of 66 and ∼60 years, respectively (6). By contrast, the median and average age at diagnosis is 57 and 55–65 years, respectively (7). The first manifestations that usually present at diagnosis include bone pain (58%), fatigue (32%) and weight loss (24%) (6). The diagnosis of myeloma is usually confirmed by the demonstration of a monoclonal protein (M-protein) in the serum or urine and/or lytic lesions on X-ray together with histological confirmation of a malignant proliferation of plasma cells (8). Treatment involves mainly irradiation, chemotherapy, autologous stem cell transplantation. Prognosis is determined via risk classification by the International Staging System (ISS) (9).

The present study reports a case of painful ulcer-like maxillary mass with multiple myeloma, which was diagnosed based on biopsy of the oral lesion.

Case report

A 69-year-old male patient presented with a chief complaint of a painful ulcerated lesion in left maxilla, for ∼1 month. Although the patient was treated with antibiotics and cortisol, the lesion was non-healing and became enlarged and painful, resulting in restriction of mouth opening and a weight loss of 4 kg during the month he was observed. Subsquently, the patient presented to the Shanghai Ninth Peoples’ Hospital Affiliated to Shanghai Jiaotong University School of Medicine (Shanghai, China) for further oral and maxillofacial surgery. His previous medical history revealed an episode of lumbar intervertebral disc prolapsed over a period of five years. The pain was exacerbated subsequent to heavy lifting, but had not progressed. The patient had no family history of cancer. Ethics approval for this study was granted by the ethics committee of Shanghai Ninth People’s Hospital affiliated to Shanghai Jiaotong University, School of Medicine (Shanghai, China). The patient provided written informed consent.

Peripheral lymphadenopathy was not observed, while the liver and spleen were unpalpable. Intraoral examination revealed an ulcerated and hemorrhagic mass in the left posterior palate near the maxilla body. The lesion extended from maxillary left third molar to maxillary left seventh molar. It had an uneven bleeding surface and measured ∼5 cm in its maximum diameter impairing the upper left buccal and palatine gingiva (Figs. 1 and 2).

Contrasted oral and maxillary computed tomography (CT) and magnetic resonance imaging (MRI) showed irregular soft tissue with destruction of the left upper-alveolar bone, periodontium and the maxillary sinus, suggesting a malignant mass (Figs. 3 and 4).

Elevated serum creatinine levels were indicative of multiple organ infiltrations. Consequently, the patient was referred for consultation to the Department of Nephrology and underwent additional examinations.

The lumbar spine MRI revealed multiple vertebral destruction (Fig. 5).

A high serum level of β2-microglobulin, hypercalcemia and lactate dehydrogenase were observed, whereas urinary Bence-Jones protein was not identified.

An incisional biopsy was performed under local anesthesia. The histological features indicated sheets of atypical plasma cells (Fig. 6). The immunohistochemical results were positive for CD138, Vs38c, EMA and immunoglobulin G (IgG) (Fig. 7), negative for L26, CD79a and CD3, and ∼60–70% positive for Ki-67 (Fig. 8). Monoclonal staining for λ was positive, whereas κ was negative. A bone marrow aspiration demonstrated 44% plasmacytosis.

Serum electrophoresis revealed myeloma protein (M-protein) secreting IgG (72.4 g/l) as well as λ light chains. According to these results the diagnosis of multiple myeloma was established as stage IIIB (Durie/Salmon staging system) and symptomatic myeloma presenting as myeloma-related organ and tissue impairment (ROTI, adapted from the International Myeloma Working Group, 2003) (Table I) (10).

Table I.

Values of complete blood count, chemistry measurements and serum protein electrophoresis.

Table I.

Values of complete blood count, chemistry measurements and serum protein electrophoresis.

ItemResultsNormal range
Hemoglobin123 g/l103–151 g/l
Platelets 171×109/l 101–320×109/l
Serum creatinine180 μmol/l44–97 μmol/l
Calcium2.82 μmol/l2.08–2.65 μmol/l
Lactate dehydrogenase220 U/l100–190 U/l
Serum globulins25 g/l32–48 g/l
β-2 microglobulin16 mg/l0.7–1.8 mg/l
γ globulins60.1 g/l6–25 g/l
Globulin peak in the urine2.75 g/24 h0–0.15 g/24 h

The patient was referred for consultation to the Deparments of Hematology and Nephrology. Chemotherapy comprising thalidomide combined with bortezomib-mitoxantronedexamethasone (PMD) was administered. The patient subsequently received autologous stem cell transplantation and remained in remission at the date of the writing of this manuscript.

Discussion

Multiple myeloma accounts for ∼1% of all types of malignancy and slightly >10% of hematologic malignancies (11). Bone marrow examination reveals a large amount of these abnormal plasma cells. Myeloma cells produce abnormal immunoglobulin (M-protein), light chain proteins (κ and λ) and other factors, such as cytokines. Excessive M-protein causes hyperviscosity of the blood. The excessive production of a monoclonal protein (M-protein) may lead to renal dysfunction. Lesions of bone are largely caused by the release of cytokines that promote bone resorption through the upregulation of osteoclast activity, differentiation and maturation (12,13).

Initial findings of the examinations conducted were: anemia in 73% of patients, bone pain in 58%, renal insufficiency in 48%, hypercalcemia in 28%, palpable liver in 4% and palpable spleen in 1% of patients. Lymphadenopathy was observed in 1% of patients (6). Maxillofacial presentations in patients with multiple myeloma are not uncommon, however, multiple myeloma is often overlooked. Epstein et al (14) examined 783 patients in the literature and indicated that ∼14% of patients had oral manifestations. Oral lesions rarely occured as the first indication of the disease (1517), whereas jaw lesions are the more common manifestation of multiple myeloma with an incidence varying from 8–15% (18). As the symptoms vary, multiple myeloma may be misdiagnosed or overlooked in the oral and maxillofacial region.

In the present case the impaired renal function was addressed by physicians. Subsequently, the patient underwent chemotherapy instead of surgery due to symptoms including swelling, mass formation, non-healing ulcer, pain, bleeding and fracture of the jawbone, tooth mobility and migration, macroglossia and radiolucent lesions. Osteolytic lesions are reported more frequently in the mandible as compared to the maxilla, particularly in the posterior teeth region, ramus and condylar process, presumably due to greater hematopoietic activity in these areas (13,18). As for the image findings, results of the CT provided detailed information regarding the extent of cortical involvement of the tumor, whereas MRI revealed marrow infiltration as well as diffuse patterns of infiltration that may not be adequately visualized using radiographic imaging alone (2).

An ulcerated, haemorhagic tissue mass of 3 × 5 cm, arising from the maxillary left third molar to the maxillary left seventh molar, was observed in the present case. Panoramic radiography and MRI/CT revealed an osteolytic lesion in the left posterior maxilla body, haziness of maxillary sinus and multiple destruction and infiltration of the lumber spine. The patient had a previous medical history of lumbar intervertebral disc prolapsed over a period of five years, although the pain associated with the prolapsed disc was not aggravated. The patient’s chief complaint was the oral lesion that had shown rapid progression. Therefore, a differential diagnosis between multiple myeloma and multiple metastatic disease should be conducted, particularly in elderly individuals. The differential diagnosis depends on the identification of abnormal monoclonal plasma cells in the full blood count, bone marrow and biopsy, M-protein in the serum or urine and a clinical image consistent with multiple myeloma.

Serum eletrophoresis identifies myeloma protein (M-protein) in ∼93% of the patients. Additionally, ∼70% of myelomas secrete IgG, with κ light chains being more common (63%) (6). In the present case, serum protein electrophoresis showed an IgG monoclonal spike of ∼72.4 g/l with the λ light chain. Urine electrophoresis may identify M-protein in ∼60% of patients. Nevertheless, no myeloma protein was detected in the urine of the patient of this study.

Immunohistochemical staining should be performed to confirm plasmacytoma. Up to 85% of plasma cell neoplasms are positive for EMA, an antibody against epithelial membrane antigen that recognizes the breast epithelial mucin complex (2). CD138 immunostaining of trephine sections is useful in determining the extent of infiltration in selected cases. L26 antibody staining of CD20 molecule, which is usually expressed on mature B cells and a subset of immature B cells, adheres to the expression patterns in normal B-cell development. As a result, plasmacytomas are usually negative for this antibody. Light chain restriction for κ or λ is usually observed and almost 70% of plasma cell neoplasms are κ-positive (20,21).

In this case, the histological and immunohistochemical results led to the diagnosis of malignant plasma-cell lesion. The MRI/CT revealed the presence of multiple oesteolytic lesions. The diagnosis of multiple myeloma was subsequently confirmed by full blood count, incisional biopsy, bone marrow biopsy and laboratory examinations.

The natural history of myeloma is heterogeneous with survival times ranging from a few weeks to >20 years. Analysis of prognostic factors is essential to compare outcomes within and between clinical trials. The Durie/Salmon staging system was published in 1975 (22) but has been superseded by the ISS reproduced in Table II (9). The ISS defines three risk categories determined by the serum concentration of β2-microglobulin and albumin. The use of staging systems to determine choice of therapy for individual patients remains unproven. As for the patient in this study, the diagnosis was symptomatic myeloma with ROTI staging III (Table II).

Table II.

The International Staging System (ISS) for multiple myeloma.a

Table II.

The International Staging System (ISS) for multiple myeloma.a

StageCriteriaMedian survival (months)
ISerum β2 microglobulin <3.5 mg/l (296 nmol/l) and serum albumin ≥3.5/dl (35 g/l or 532 μmol/l)62
IINeither I or IIIb45
IIISerum β2 microglobulin ≥5.5 mg/l (465 nmol/l)29

a Adapted from Greipp et al (10).

b There are two sub-categories: serum β2 microglobulin <3.5 mg/l, but serum albumin <3.5 g/l or serum β2 microglobulin 3.5–5.5 mg irrespective of the serum albumin level.

Chemotherapy is only suggested for patients with symptomatic myeloma based on the presence of ROTI (10). In this case, we used PMD combined with thalidomide as an induction therapy prior to autologous stem-cell transplantation. Therefore, the prognosis of this patient is to continue be followed up.

In conclusion, although maxillofacial manifestation in patients with multiple myeloma is not uncommon, multiple myeloma is often overlooked and misdiagnosed. Therefore, findings of this case report suggest that multiple myeloma should be considered as a differential diagnosis and related laboratory/radiographic evaluations should be administered when considering a patient whose chief complaint is unusual maxillary pain.

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APA
Zhao, X.J., Sun, J., Wang, Y.D., & Wang, L. (2014). Maxillary pain is the first indication of the presence of multiple myeloma: A case report. Molecular and Clinical Oncology, 2, 59-64. https://doi.org/10.3892/mco.2013.200
MLA
Zhao, X. J., Sun, J., Wang, Y. D., Wang, L."Maxillary pain is the first indication of the presence of multiple myeloma: A case report". Molecular and Clinical Oncology 2.1 (2014): 59-64.
Chicago
Zhao, X. J., Sun, J., Wang, Y. D., Wang, L."Maxillary pain is the first indication of the presence of multiple myeloma: A case report". Molecular and Clinical Oncology 2, no. 1 (2014): 59-64. https://doi.org/10.3892/mco.2013.200