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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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August-2017 Volume 7 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Prognostic significance of osteopontin in acute myeloid leukemia: A meta‑analysis

  • Authors:
    • Yong‑Bing Chen
    • Si‑Mei Ren
    • Si‑Dan Li
    • Zhongli Du
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, PLA Army General Hospital, Beijing 100700, P.R. China, Department of Hematology/National Center for Clinical Laboratories, Beijing Hospital, Beijing 100730, P.R. China, Beijing Key Laboratory of Pediatric Hematology Oncology/National Key Discipline of Pediatrics, Ministry of Education/Key Laboratory of Major Diseases in Children, Ministry of Education/Hematology Oncology Center, Beijing Children's Hospital, Capital Medical University, Beijing 100045, P.R. China
  • Pages: 275-280
    |
    Published online on: June 28, 2017
       https://doi.org/10.3892/mco.2017.1302
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Abstract

Osteopontin (OPN) has been investigated in the field of tumor research for several years. However, the prognostic role of OPN overexpression in acute myeloid leukemia (AML) remains controversial. A meta‑analysis of four studies, including a total of 492 patients, was performed to determine the association of OPN with overall survival (OS) in AML patients. The random‑effects model of Der Simonian and Laird was used to synthesize data; hazard ratio (HR) with its 95% confidence interval (CI) was used as the effect size estimate. It was observed that serum‑based OPN was inversely correlated with OS and the difference was statistically significant (HR=1.83; 95% CI: 1.43‑2.35; P<0.001). Experimental findings indicate that OPN overexpression is associated with a poor prognosis in AML and may be of prognostic value for AML stage and metastasis.

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Copy and paste a formatted citation
Spandidos Publications style
Chen YB, Ren SM, Li SD and Du Z: Prognostic significance of osteopontin in acute myeloid leukemia: A meta‑analysis. Mol Clin Oncol 7: 275-280, 2017.
APA
Chen, Y., Ren, S., Li, S., & Du, Z. (2017). Prognostic significance of osteopontin in acute myeloid leukemia: A meta‑analysis. Molecular and Clinical Oncology, 7, 275-280. https://doi.org/10.3892/mco.2017.1302
MLA
Chen, Y., Ren, S., Li, S., Du, Z."Prognostic significance of osteopontin in acute myeloid leukemia: A meta‑analysis". Molecular and Clinical Oncology 7.2 (2017): 275-280.
Chicago
Chen, Y., Ren, S., Li, S., Du, Z."Prognostic significance of osteopontin in acute myeloid leukemia: A meta‑analysis". Molecular and Clinical Oncology 7, no. 2 (2017): 275-280. https://doi.org/10.3892/mco.2017.1302
Copy and paste a formatted citation
x
Spandidos Publications style
Chen YB, Ren SM, Li SD and Du Z: Prognostic significance of osteopontin in acute myeloid leukemia: A meta‑analysis. Mol Clin Oncol 7: 275-280, 2017.
APA
Chen, Y., Ren, S., Li, S., & Du, Z. (2017). Prognostic significance of osteopontin in acute myeloid leukemia: A meta‑analysis. Molecular and Clinical Oncology, 7, 275-280. https://doi.org/10.3892/mco.2017.1302
MLA
Chen, Y., Ren, S., Li, S., Du, Z."Prognostic significance of osteopontin in acute myeloid leukemia: A meta‑analysis". Molecular and Clinical Oncology 7.2 (2017): 275-280.
Chicago
Chen, Y., Ren, S., Li, S., Du, Z."Prognostic significance of osteopontin in acute myeloid leukemia: A meta‑analysis". Molecular and Clinical Oncology 7, no. 2 (2017): 275-280. https://doi.org/10.3892/mco.2017.1302
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