Prognostic significance of osteopontin in acute myeloid leukemia: A meta‑analysis

Chen,Yong‑Bing; Ren,Si‑Mei; Li,Si‑Dan; Du,Zhongli

doi:10.3892/mco.2017.1302

Prognostic significance of osteopontin in acute myeloid leukemia: A meta‑analysis

Authors:
- Yong‑Bing Chen
- Si‑Mei Ren
- Si‑Dan Li
- Zhongli Du
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Affiliations: Department of Hepatobiliary Surgery, PLA Army General Hospital, Beijing 100700, P.R. China, Department of Hematology/National Center for Clinical Laboratories, Beijing Hospital, Beijing 100730, P.R. China, Beijing Key Laboratory of Pediatric Hematology Oncology/National Key Discipline of Pediatrics, Ministry of Education/Key Laboratory of Major Diseases in Children, Ministry of Education/Hematology Oncology Center, Beijing Children's Hospital, Capital Medical University, Beijing 100045, P.R. China
Published online on: June 28, 2017 https://doi.org/10.3892/mco.2017.1302
Pages: 275-280

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Abstract

Osteopontin (OPN) has been investigated in the field of tumor research for several years. However, the prognostic role of OPN overexpression in acute myeloid leukemia (AML) remains controversial. A meta‑analysis of four studies, including a total of 492 patients, was performed to determine the association of OPN with overall survival (OS) in AML patients. The random‑effects model of Der Simonian and Laird was used to synthesize data; hazard ratio (HR) with its 95% confidence interval (CI) was used as the effect size estimate. It was observed that serum‑based OPN was inversely correlated with OS and the difference was statistically significant (HR=1.83; 95% CI: 1.43‑2.35; P<0.001). Experimental findings indicate that OPN overexpression is associated with a poor prognosis in AML and may be of prognostic value for AML stage and metastasis.