Neuroendocrine carcinoma of the lung expressing anaplastic lymphoma kinase on high‑sensitivity immunohistochemistry: A case report

Miyoshi,Kotoko; Adachi,Yasushi; Nakaji,Hitoshi; Okamura,Akiharu; Sakai,Yasuhiro; Hirano,Ryuji; Yahata,Shinsuke; Li,Ming; Ikehara,Susumu

doi:10.3892/mco.2017.1308

August-2017 Volume 7 Issue 2

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

August-2017 Volume 7 Issue 2

Full Size Image

Case Report Open Access

Neuroendocrine carcinoma of the lung expressing anaplastic lymphoma kinase on high‑sensitivity immunohistochemistry: A case report

Authors:
- Kotoko Miyoshi
- Yasushi Adachi
- Hitoshi Nakaji
- Akiharu Okamura
- Yasuhiro Sakai
- Ryuji Hirano
- Shinsuke Yahata
- Ming Li
- Susumu Ikehara
View Affiliations / Copyright

Affiliations: Department of Respiratory Medicine, Toyooka Hospital, Toyooka, Hyogo, Japan, Department of Diagnostic Pathology, Toyooka Hospital, Toyooka, Hyogo, Japan, Department of Diagnostic Pathology, Kakogawa Central Hospital, Kakogawa, Hyogo, Japan, Department of Diagnostic Pathology, Kobe University Graduate School of Medicine/School of Medicine, Kobe, Hyogo, Japan, Division of Thoracic and Cardiovascular Surgery, Toyooka Hospital, Toyooka, Hyogo, Japan, Department of Internal General Medicine, Hamasaka Public Hospital, Hamasaka, Hyogo, Japan, Department of Stem Cell Disorders, Kansai Medical University, Hirakata, Osaka, Japan

Copyright: © Miyoshi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 188-192
|
Published online on: June 29, 2017

https://doi.org/10.3892/mco.2017.1308
Expand metrics +

Abstract

It has been reported that anaplastic lymphoma kinase (ALK) protein is expressed in a proportion of non‑small‑cell carcinomas (mainly adenocarcinomas). By contrast, high‑sensitivity immunohistochemistry (IHC) rarely detects ALK protein expression in neuroendocrine carcinomas (NECs) of the lung, which include small‑cell carcinomas and large‑cell neuroendocrine carcinomas (LCNECs). We herein present a case of NEC that was identified as ALK‑positive via high‑sensitivity IHC. A 51‑year‑old man was diagnosed with small‑cell carcinoma in the upper lobe of the right lung. Although high‑sensitivity IHC revealed that the tumor weakly expressed the ALK protein, no fusion gene with ALK was found using fluorescence in situ hybridization (FISH). Standard chemotherapy was administered to the patient. Six months after the first visit to the hospital for the tumor, another tumor was identified in the upper lobe of the left lung. The tumor was resected and diagnosed as NEC displaying LCNEC‑like characteristics. This NEC also moderately expressed ALK protein by high‑sensitivity IHC, without exhibiting fusion genes with ALK on FISH. These data suggest that the presence of ALK fusion genes should be confirmed by FISH or reverse transcription polymerase chain reaction, even if high‑sensitivity IHC for ALK protein is positive in lung cancer.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Neuroendocrine carcinoma of the lung expressing anaplastic lymphoma kinase on high‑sensitivity immunohistochemistry: A case report

This article is mentioned in:

Abstract

Related Articles