Aldehyde dehydrogenase 1 expression has prognostic significance in patients with glioma

  • Authors:
    • Jun Wang
    • Cheng‑Liang Yang
    • Li‑Li Zou
  • View Affiliations

  • Published online on: August 28, 2017     https://doi.org/10.3892/mco.2017.1396
  • Pages: 885-890
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Abstract

As a cancer stem cell marker associated with tumorigenesis, aldehyde dehydrogenase 1 (ALDH1) has recently been identified in gliomas. However, an insufficient number of clinical studies have been published to demonstrate its prognostic significance in glioma. In the present study, a systematic meta‑analysis was performed to comprehensively evaluate the correlation of ALDH1 with age, sex, the World Health Organization (WHO) grade, and overall survival (OS) in patients with glioma. A search of relevant publications was conducted to select eligible studies on this subject, and the pooled hazard ratios (HRs) and related risks (RRs) with 95% confidence intervals (95% CIs) were assessed. Publication bias was also evaluated using Begg's funnel plots. A total of 6 articles were identified that included a total of 1,057 patients. OS analysis revealed that a high expression of ALDH1 was significantly associated with poor 5‑year OS (n=6; HR, 2.10; 95% CI, 1.13‑3.91; P<0.0001), and a high WHO grade (III+IV; n=4; RR, 2.28; 95% CI, 1.31‑3.99; P=0.001). In conclusion, a high expression of ALDH1 is associated with a high WHO grade of gliomas and a worse prognosis in patients with glioma. Further, well‑designed clinical studies are required to confirm its role in the process of selecting a suitable therapeutic approach in glioma.

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November-2017
Volume 7 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Wang J, Yang CL and Zou LL: Aldehyde dehydrogenase 1 expression has prognostic significance in patients with glioma. Mol Clin Oncol 7: 885-890, 2017
APA
Wang, J., Yang, C., & Zou, L. (2017). Aldehyde dehydrogenase 1 expression has prognostic significance in patients with glioma. Molecular and Clinical Oncology, 7, 885-890. https://doi.org/10.3892/mco.2017.1396
MLA
Wang, J., Yang, C., Zou, L."Aldehyde dehydrogenase 1 expression has prognostic significance in patients with glioma". Molecular and Clinical Oncology 7.5 (2017): 885-890.
Chicago
Wang, J., Yang, C., Zou, L."Aldehyde dehydrogenase 1 expression has prognostic significance in patients with glioma". Molecular and Clinical Oncology 7, no. 5 (2017): 885-890. https://doi.org/10.3892/mco.2017.1396