Aldehyde dehydrogenase 1 expression has prognostic significance in patients with glioma

Wang,Jun; Yang,Cheng‑Liang; Zou,Li‑Li

doi:10.3892/mco.2017.1396

November-2017 Volume 7 Issue 5

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November-2017 Volume 7 Issue 5

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Article

Aldehyde dehydrogenase 1 expression has prognostic significance in patients with glioma

Authors:
- Jun Wang
- Cheng‑Liang Yang
- Li‑Li Zou
View Affiliations / Copyright

Affiliations: Translational Neuroscience and Neural Regeneration and Repair Institute/Institute of Cell Therapy, The First Hospital of Yichang, China Three Gorges University, Yichang, Hubei 443002, P.R. China
Pages: 885-890
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Published online on: August 28, 2017

https://doi.org/10.3892/mco.2017.1396
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Abstract

As a cancer stem cell marker associated with tumorigenesis, aldehyde dehydrogenase 1 (ALDH1) has recently been identified in gliomas. However, an insufficient number of clinical studies have been published to demonstrate its prognostic significance in glioma. In the present study, a systematic meta‑analysis was performed to comprehensively evaluate the correlation of ALDH1 with age, sex, the World Health Organization (WHO) grade, and overall survival (OS) in patients with glioma. A search of relevant publications was conducted to select eligible studies on this subject, and the pooled hazard ratios (HRs) and related risks (RRs) with 95% confidence intervals (95% CIs) were assessed. Publication bias was also evaluated using Begg's funnel plots. A total of 6 articles were identified that included a total of 1,057 patients. OS analysis revealed that a high expression of ALDH1 was significantly associated with poor 5‑year OS (n=6; HR, 2.10; 95% CI, 1.13‑3.91; P<0.0001), and a high WHO grade (III+IV; n=4; RR, 2.28; 95% CI, 1.31‑3.99; P=0.001). In conclusion, a high expression of ALDH1 is associated with a high WHO grade of gliomas and a worse prognosis in patients with glioma. Further, well‑designed clinical studies are required to confirm its role in the process of selecting a suitable therapeutic approach in glioma.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Aldehyde dehydrogenase 1 expression has prognostic significance in patients with glioma

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Abstract

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