Open Access

Intravascular large B‑cell lymphoma associated with myelofibrosis: A case report

  • Authors:
    • Jong Gwon Choi
    • Hwan Hwi Cho
    • Sang Rok Kang
    • Se Min Jang
    • Eun Hyung Yoo
    • Hyun Jung Cho
    • Sun Moon Kim
    • Do Yeun Cho
  • View Affiliations

  • Published online on: August 28, 2017     https://doi.org/10.3892/mco.2017.1398
  • Pages: 798-802
  • Copyright: © Choi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Myelofibrosis (MF) is often accompanied by chronic myeloid leukemia, hairy cell leukemia, or certain primary myeloproliferative neoplasms, but is rarely associated with lymphoid neoplasms. We herein describe a case of intravascular large B‑cell lymphoma (IVLBCL) with MF. IVLBCL is a rare, aggressive type of extranodal B‑cell lymphoma, defined by proliferation of lymphomatous cells within small‑to medium‑sized vessels. A 60‑year‑old woman was admitted to the hospital with anemia, thrombocytopenia and fever. Bone marrow biopsy findings included trilineage hematopoiesis, increased numbers of immature cells, markedly abnormal and enlarged megakaryocytes, and diffuse fibrosis in multiple focal areas throughout the entire bone marrow space. When the patient was first hospitalized, hepatosplenomegaly was not present. Although initially considered during differential diagnosis, an aggressive lymphoma could not be diagnosed prior to colonoscopy, which was conducted 4 weeks after admission. A biopsy of the terminal ileum revealed IVLBCL with cells with atypical nuclei. Immunophenotyping of the atypical large cells yielded a positive result for CD79a and negative results for terminal deoxynucleotidyl transferase, myeloperoxidase, CD3, CD10, CD20, B‑cell lymphoma (Bcl)‑2, Bcl‑6 and cytomegalovirus. The patient was diagnosed with IVLBCL complicated by MF. This case may serve as a reminder that IVLBCL may be the cause of secondary MF.

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November-2017
Volume 7 Issue 5

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Spandidos Publications style
Choi JG, Cho HH, Kang SR, Jang SM, Yoo EH, Cho HJ, Kim SM and Cho DY: Intravascular large B‑cell lymphoma associated with myelofibrosis: A case report. Mol Clin Oncol 7: 798-802, 2017
APA
Choi, J.G., Cho, H.H., Kang, S.R., Jang, S.M., Yoo, E.H., Cho, H.J. ... Cho, D.Y. (2017). Intravascular large B‑cell lymphoma associated with myelofibrosis: A case report. Molecular and Clinical Oncology, 7, 798-802. https://doi.org/10.3892/mco.2017.1398
MLA
Choi, J. G., Cho, H. H., Kang, S. R., Jang, S. M., Yoo, E. H., Cho, H. J., Kim, S. M., Cho, D. Y."Intravascular large B‑cell lymphoma associated with myelofibrosis: A case report". Molecular and Clinical Oncology 7.5 (2017): 798-802.
Chicago
Choi, J. G., Cho, H. H., Kang, S. R., Jang, S. M., Yoo, E. H., Cho, H. J., Kim, S. M., Cho, D. Y."Intravascular large B‑cell lymphoma associated with myelofibrosis: A case report". Molecular and Clinical Oncology 7, no. 5 (2017): 798-802. https://doi.org/10.3892/mco.2017.1398