Identification of i(X)(p10) as the sole molecular abnormality in atypical chronic myeloid leukemia evolved into acute myeloid leukemia

  • Authors:
    • Carmelo Gurnari
    • Paola Panetta
    • Emiliano Fabiani
    • Anna Maria Nardone
    • Diana Postorivo
    • Giulia Falconi
    • Luca Franceschini
    • Manuela Rizzo
    • Vito Mario Rapisarda
    • Eleonora De Bellis
    • Francesco Lo‑Coco
    • Maria Teresa Voso
  • View Affiliations

  • Published online on: December 29, 2017     https://doi.org/10.3892/mco.2017.1543
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Abstract

The World Health Organization classifies atypical chronic myeloid leukemia (aCML) as a myeloproliferative/myelodisplastic hematological disorder. The primary manifestations are leukocytosis with disgranulopoiesis, absence of basophilia and/or monocytosis, splenomegaly and absence of Philadelphia chromosome or BCR/ABL fusion. Overall 50‑65% of patients demonstrate karyotypic abnormalities, although no specific cytogenetic alterations have been associated with this disease. X chromosome alterations have been rarely reported in myeloid malignancies. Although Isodicentric X, idic(X)(q13) is well known in females with myelodysplastic syndromes (MDS), little data are available on X isochromosome and its pathogenetic potential in these disorders. i(X)(p10) is observed in a variety of hematologic malignancies, both myeloid and lymphoid, as a unique abnormality, as well as part of a more complex karyotype, in females and less frequently in male patients. The present report describes the first patient with aCML, with documented isolated i(X)(p10), who developed a secondary acute myeloid leukemia (sAML).

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APA
Gurnari, C., Panetta, P., Fabiani, E., Nardone, A., Postorivo, D., Falconi, G. ... Voso, M. (1899). Identification of i(X)(p10) as the sole molecular abnormality in atypical chronic myeloid leukemia evolved into acute myeloid leukemia. Molecular and Clinical Oncology, 0, 0-0. https://doi.org/10.3892/mco.2017.1543
MLA
Gurnari, C., Panetta, P., Fabiani, E., Nardone, A., Postorivo, D., Falconi, G., Franceschini, L., Rizzo, M., Rapisarda, V., De Bellis, E., Lo‑Coco, F., Voso, M."Identification of i(X)(p10) as the sole molecular abnormality in atypical chronic myeloid leukemia evolved into acute myeloid leukemia". Molecular and Clinical Oncology 0.0 (1899): 0-0.
Chicago
Gurnari, C., Panetta, P., Fabiani, E., Nardone, A., Postorivo, D., Falconi, G., Franceschini, L., Rizzo, M., Rapisarda, V., De Bellis, E., Lo‑Coco, F., Voso, M."Identification of i(X)(p10) as the sole molecular abnormality in atypical chronic myeloid leukemia evolved into acute myeloid leukemia". Molecular and Clinical Oncology 0, no. 0 (1899): 0-0. https://doi.org/10.3892/mco.2017.1543